Used 2021 Lexus RX for Sale Nationwide

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2022 Lexus RX

350L FWD

76,698 miles

$29,990

Great Deal

Homosassa, FL

1 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 290 hp 3.5L V6
Exterior color:: Black
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Glazed Caramel
Transmission:: 8-Speed Automatic
Mileage:: 76,698
Stock number:: 21X9199A
VIN:: JTJHZKEA9N2024215

2022 Lexus RX

350 FWD

52,539 miles

$33,281

Great Deal

Statesville, NC

1 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: White
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Birch
Transmission:: 8-Speed Automatic
Mileage:: 52,539
Stock number:: 4406F
VIN:: 2T2AZMAA3NC229547

2020 Lexus RX

350L FWD

107,203 miles

$25,293

Great Deal

Shawnee, OK

1 mi away

Year:: 2020
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 290 hp 3.5L V6
Exterior color:: Ultra White
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: White (Parchment)
Transmission:: 8-Speed Automatic
Mileage:: 107,203
Stock number:: S017809
VIN:: JTJHZKEA7L2017809

2022 Lexus RX

350 F Sport Handling AWD

35,847 miles

$41,992

Great Deal

Charlotte, NC

1 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Matador Red Mica
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: Automatic
Mileage:: 35,847
Stock number:: P8770A
VIN:: 2T2YZMDA4NC335662

2022 Lexus RX

350 FWD

46,630 miles

$37,500

Great Deal

Grapevine, TX

1 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Black (Caviar)
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Birch
Transmission:: 8-Speed Automatic
Mileage:: 46,630
Stock number:: S3290803A
VIN:: 2T2HZMAA1NC246507

2022 Lexus RX

350 FWD

30,662 miles

$36,690

Great Deal

Denton, TX

1 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Atomic Silver
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: 8-Speed Automatic
Mileage:: 30,662
Stock number:: NC238357
VIN:: 2T2HZMAA1NC238357

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2021 Lexus RX

350 FWD

27,419 miles

$36,999

Good Deal

Glendale, AZ

1 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Nebula Gray Pearl
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Ash
Transmission:: 8-Speed Automatic
Mileage:: 27,419
Stock number:: PV60226
VIN:: 2T2AZMAA9MC185732

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2021 Lexus RX

350 FWD

62,074 miles

$31,000

Great Deal

Luling, TX

1 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Black (Obsidian)
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: 8-Speed Automatic
Mileage:: 62,074
Stock number:: MC203887
VIN:: 2T2HZMAA0MC203887

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2020 Lexus RX

350 F Sport Performance AWD

96,884 miles

$30,986

Good Deal

Glenwood Springs, CO

1 mi away

Year:: 2020
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Black (Obsidian)
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Circuit Red
Transmission:: 8-Speed Automatic
Mileage:: 96,884
Stock number:: 115880A
VIN:: 2T2YZMDA9LC213148

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2021 Lexus RX

350 AWD

91,826 miles

$28,599

Good Deal

Marion, IN

1 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Bronze
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: 8-Speed Automatic
Mileage:: 91,826
Stock number:: T6568A
VIN:: 2T2HZMDA6MC302628

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2021 Lexus RX

350 AWD

77,239 miles

$29,950

Great Deal

Dover, PA

1 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Black (Caviar)
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Glazed Caramel
Transmission:: 8-Speed Automatic
Mileage:: 77,239
Stock number:: B85210A
VIN:: 2T2HZMDAXMC274879

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2021 Lexus RX

350 AWD

63,255 miles

$33,987

Good Deal

Certified Pre-Owned

Holyoke, MA

1 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: White
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Glazed Caramel
Transmission:: 8-Speed Automatic
Mileage:: 63,255
Stock number:: B7111A
VIN:: 2T2HZMDA7MC305666

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2021 Lexus RX

350 F Sport AWD

36,949 miles

$37,635

Good Deal

Schaumburg, IL

1 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Nightfall Mica
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Circuit Red
Transmission:: 8-Speed Automatic
Mileage:: 36,949
Stock number:: P1320B
VIN:: 2T2SZMDA4MC264595

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2020 Lexus RX

350 FWD

53,547 miles

$29,996

Great Deal

Henderson, NV

1 mi away

Year:: 2020
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: White
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Brown (Tan)
Transmission:: Automatic
Mileage:: 53,547
Stock number:: CLC168783
VIN:: 2T2HZMAA0LC168783

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2020 Lexus RX

350 FWD

72,791 miles

$29,095

Great Deal

High Point, NC

1 mi away

Year:: 2020
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Nightfall Mica
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: White (Parchment)
Transmission:: 8-Speed Automatic
Mileage:: 72,791
Stock number:: 157491A
VIN:: 2T2AZMAA7LC157491

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2022 Lexus RX

350 AWD

38,589 miles

$39,502

Fair Deal

Taylorsville, IN

1 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Nightfall Mica
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Birch
Transmission:: 8-Speed Automatic
Mileage:: 38,589
Stock number:: TP12146
VIN:: 2T2HZMDA0NC331818

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2021 Lexus RX

350 FWD

91,145 miles

$28,984

Good Deal

Montgomery, AL

1 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: White Pearl
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: White (Parchment)
Transmission:: 8-Speed Automatic
Mileage:: 91,145
Stock number:: U200282
VIN:: 2T2HZMAA6MC200282

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2020 Lexus RX

350L FWD

89,738 miles

$25,749

Great Deal

Tamarac, FL

1 mi away

Year:: 2020
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 290 hp 3.5L V6
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: Automatic
Mileage:: 89,738
Stock number:: N728332A
VIN:: JTJHZKEA1L2018289

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2020 Lexus RX

350 AWD

24,507 miles

$38,825

Fair Deal

Lynnwood, WA

1 mi away

Year:: 2020
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Eminent White Pearl
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: White (Parchment w/Matte Bamboo Trim)
Transmission:: 8-Speed Automatic
Mileage:: 24,507
Stock number:: A8227A
VIN:: 2T2HZMDA8LC243354

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2022 Lexus RX

350 F Sport Handling AWD

46,394 miles

$41,183

Great Deal

Hiawatha, IA

1 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Silver
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Red
Transmission:: 8-Speed Automatic
Mileage:: 46,394
Stock number:: F31781
VIN:: 2T2YZMDA9NC312572

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2022 Lexus RX

350 FWD

62,521 miles

$32,298

Great Deal

Manvel, TX

1 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Silver
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Glazed Caramel
Transmission:: 8-Speed Automatic
Mileage:: 62,521
Stock number:: NC242866A
VIN:: 2T2HZMAA9NC242866

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2021 Lexus RX

350 FWD

29,233 miles

$35,990

Great Deal

Lafayette, LA

1 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Black (Caviar)
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Birch
Transmission:: 8-Speed Automatic
Mileage:: 29,233
Stock number:: GN2415A
VIN:: 2T2HZMAA4MC184485

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2022 Lexus RX

350 FWD

13,896 miles

$40,888

Good Deal

Certified Pre-Owned

Henderson, NV

1 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Black (Caviar)
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: 8-Speed Automatic
Mileage:: 13,896
Stock number:: H251064B
VIN:: 2T2AZMAA2NC232827

Overview

Reviews

FAQs

CarGurus Analysis: 2021 Lexus RX

Summary

With 1,829 currently listed for sale on CarGurus and an average price of $35,773.40, 32.3% of 2021 Lexus RXs for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Lexus RX 4.7 / 5 stars and CarGurus experts gave it an 7.8 / 10.
79% of 2021 RX models on CarGurus are accident free.
The 2021 Lexus RX combined luxurious comfort with reliability, featuring upgraded safety technology and a smooth ride, although it had some limitations in performance and technology usability.

Why it stands out

The 2021 Lexus RX distinguished itself as a luxury SUV that emphasized comfort and reliability, making it an appealing choice for buyers seeking both style and practicality. It featured an excellent ride quality and offered great value for money, ensuring a pleasant driving experience. Additionally, the introduction of new standard safety systems enhanced its appeal by prioritizing passenger protection.

Other model years to consider

2020 Lexus RX: This year offers $33,379.27 average price, 33% good/great deals, 4.8/5 user rating, 8.2/10 expert rating, 1,269 listings.
2023 Lexus RX: This year offers $47,405.06 average price, 37% good/great deals, 4.6/5 user rating, 7.2/10 expert rating, 3,056 listings.
2022 Lexus RX: This year offers $40,414.56 average price, 36% good/great deals, 4.6/5 user rating, 7.3/10 expert rating, 2,526 listings.

This analysis is based on CarGurus' proprietary market data from December 16, 2025, CarGurus experts' opinions, and generative AI.

4.8 Overall rating

(26 reviews)

Archie C

5.0

Reviewed a 2021 Lexus RX on Oct 13, 2024

Very reliable stylish looking drives well. Good suspension. Fun to drive

Dan F

5.0

Reviewed a 2021 Lexus RX on Mar 26, 2024

Condition of the vehicle was 10/10. Interior was detailed extremely well. Mechanically it all checked out as well. Only issue was since it is a Canadian vehicle the digital climate controls appear to be stuck in Celsius. Could be a troubleshoot to resolve it but other than that perfect vehicle.

Haidar A

5.0

Reviewed a 2021 Lexus 350L AWD on Apr 25, 2024

The car is perfect if only the brakes were as responsive of a German car.

Ann W

5.0

Reviewed a 2021 Lexus RX on Feb 22, 2023

This car is beautiful and drives so smooth.

Anonymous

5.0

Reviewed a 2021 Lexus RX on Nov 04, 2023

Perfect for me and my family (except for the Parchment interior that my kids will probably ruin) but I love it!so I will do everything to keep it clean.. this car is superior family luxury! Have kid? Needs spacious trunk and seating but doesnt want it looking huge and bulky outside? Needs reliability? Need quality? Need LUXURY? look no further the RX 350 IS THE CAR FOR YOU!

2021 Lexus RX FAQs

How much does the 2021 Lexus RX cost?

The average 2021 Lexus RX costs about $35,603.04. The average price has decreased by -4.6% since last year. The 1735 for sale on CarGurus range from $17,988 to $60,795 in price.

Is the 2021 Lexus RX a good car?

CarGurus experts gave the 2021 Lexus RX an overall rating of 7.8/10 and 2021 Lexus RX owners have rated the vehicle a 4.7/5 stars on average. If a vehicle has both strong expert and owner reviews, you can feel confident in its quality. If either expert reviews, owner reviews, or both are spotty, you might want to do some research to figure out where the car falls short.

How many 2021 Lexus RX vehicles have no reported accidents or damage?

1365 out of 1735 for sale have no reported accidents or damage.

Is the 2021 Lexus RX safe?

CarGurus experts gave the 2021 Lexus RX a safety rating of 8/10.

What is the fuel economy of the 2021 Lexus RX?

Depending on the engine and options, the 2021 Lexus RX gets between 21 and 23 MPG (or MPGe).

What fuel types are available?

Gasoline engines are available.

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