Used 2021 Mercedes-Benz E-Class for Sale near Duffield, VA

## Summary - With 960 currently listed for sale on CarGurus and an **average price of $38,198.00**, 33.8% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals. - **Favorably reviewed:** Owners rated the 2021 Mercedes-Benz E-Class 4.53 / 5 stars and CarGurus experts gave it an 8.33 / 10. - **77.0% of 2021 E-Class models on CarGurus are accident free**. - The 2021 Mercedes-Benz E-Class received a mid-cycle update for its infotainment system, engines, and exterior styling while maintaining its reputation for performance and luxury. ## Why it stands out The 2021 Mercedes-Benz E-Class sets itself apart as a supreme midsize luxury sedan characterized by its blend of performance, comfort, and cutting-edge technology. With the introduction of electrified inline-six powertrains, specifically in the E450 model, the 2021 iteration offers a completely reworked engine lineup while ensuring compliance with stricter emissions standards. Owners have praised the E-Class for its stylish design, with contemporary updates to the exterior that include a refined front fascia and sophisticated interior finishes that exude luxury. Despite being a mid-size executive car, it continues to appeal to buyers seeking an elegant balance of speed and comfort, although some have critiqued the advanced safety features as non-standard. ## Other model years to consider - **[2022 Mercedes-Benz E-Class](https://www.cargurus.com/Cars/l-Used-2022-Mercedes-Benz-E-Class-c31854)** - Average price: $40,957.00 - Good/great deal percentage: 33.6% - User rating: 5 / 5 - Total listings: 1,121 - **[2019 Mercedes-Benz E-Class](https://www.cargurus.com/Cars/l-Used-2019-Mercedes-Benz-E-Class-c28109)** - Average price: $27,710.00 - Good/great deal percentage: 34.6% - User rating: 4.88 / 5 - Total listings: 1,204 - **[2023 Mercedes-Benz E-Class](https://www.cargurus.com/Cars/l-Used-2023-Mercedes-Benz-E-Class-c32301)** - Average price: $50,926.00 - Good/great deal percentage: 34.9% - User rating: 5 / 5 - Total listings: 954 This analysis is based on CarGurus' proprietary market data from February 20, 2026, CarGurus experts' opinions, and generative AI.