Used 2021 Mercedes-Benz E-Class for Sale near Chicago, IL
136 results
Sponsored by Maserati, Alfa Romeo & Fiat of Naperville
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 129 currently listed for sale near Chicago, IL and an average price of $54,850.00, 38.8% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
94.6% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update with a new infotainment system, a range of body styles, and innovative engine options that enhance both performance and efficiency.
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall
Summary
With 129 currently listed for sale near Chicago, IL and an average price of $54,850.00, 38.8% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
94.6% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update with a new infotainment system, a range of body styles, and innovative engine options that enhance both performance and efficiency.
Why it stands out
The 2021 Mercedes-Benz E-Class represents the pinnacle of luxury sedans, combining cutting-edge technology with unparalleled performance. It offers a diverse lineup of four body styles and a variety of powertrains, including electrified options that provide both speed and efficiency. The revamped infotainment system significantly improves user experience, bringing a modern touch to the already elegant cabin. Reviewers particularly appreciate the car's luxurious materials, robust safety features, and comfortable ride. However, some buyers have noted concerns regarding the performance of specific advanced driver-assistance features and the choice of synthetic instead of genuine leather in some trims. With an expert rating of 8.33 out of 10, the E-Class continues to be a leader in its segment, appealing to those who seek a blend of prestige and practicality.
Other model years to consider
- Average price: $42,272.00
- Good/great deal percentage: 44.0%
- User rating: 5 / 5
- Total listings: 134
- Average price: $41,328.00
- Good/great deal percentage: 29.1%
- User rating: 5 / 5
- Total listings: 165
- Average price: $25,217.00
- Good/great deal percentage: 24.2%
- User rating: 4.76 / 5
- Total listings: 236
This analysis is based on CarGurus' proprietary market data from April 21, 2026, CarGurus experts' opinions, and generative AI.
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2026 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Sitting squarely in the midsize luxury sedan segment, the 2026 Mercedes-Benz E-Class competes with the BMW 5 Series, the Audi A6, and the Lexus ES.
2025 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Thoroughly updated last year, the Mercedes-Benz E-Class returns for 2025 with added safety equipment, a new entry-level trim, and an AMG E 53 Hybrid version designed to deliver equal parts performance and efficiency.
4.7 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Teddi R
Reviewed a 2021 Mercedes-Benz E-Class on Jun 2, 2024
You cant go wrong with any of the E-class Mercedes! They are bulletproof cars with NO issues.
Anonymous
Reviewed a 2021 Mercedes-Benz E-Class on May 2, 2024
Ive owned many Mercedes over the years but always come back to Model E. Best size, forward technology and usually handsome exterior/interior
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
2021 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| E 450 Cabriolet RWD | $71,950 |
| AMG E 63 S Wagon 4MATIC | $112,450 |
| E 450 4MATIC Coupe AWD | $67,450 |
| E 450 4MATIC Sedan AWD | $62,000 |
| AMG E 63 S Sedan 4MATIC | $107,500 |
| AMG 53 E Sedan 4MATIC | $73,900 |
| E 350 RWD | $54,250 |
| E 350 4MATIC | $56,750 |
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
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