Used 2021 Mercedes-Benz E-Class E 350 4MATIC for SaleNationwide
64 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 37,920
- Stock #:
- 63931A
- VIN:
- W1KZF8EB0MA923339
New arrival
2021 Mercedes-Benz E-Class
E 350 4MATIC
37,920 mi
Belmont, MA
Good Deal
$32,310
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 24,475
- Stock #:
- AMA914312H
- VIN:
- W1KZF8EB1MA914312
2021 Mercedes-Benz E-Class
E 350 4MATIC
24,475 mi
Clarksville, TN
Great Deal
$33,336
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,345
- Stock #:
- 20313MA4
- VIN:
- W1KZF8EB8MA920608
2021 Mercedes-Benz E-Class
E 350 4MATIC
30,345 mi
North Haven, CT
Great Deal
$33,145
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- designo Cardinal Red Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- designo Macchiato Beige/Saddle Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,328
- Stock #:
- T10983
- VIN:
- W1KZF8EB6MA997641
New arrival
2021 Mercedes-Benz E-Class
E 350 4MATIC
23,328 mi
Marion, OH
Fair Deal
$36,348
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- CREAM
- Transmission:
- Automatic
- Mileage:
- 37,098
- Stock #:
- 28949349
- VIN:
- W1KZF8EB1MA892859
2021 Mercedes-Benz E-Class
E 350 4MATIC
37,098 mi
Knoxville, TN
Fair Deal
$32,998
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,538
- Stock #:
- F6743
- VIN:
- W1KZF8EBXMA994886
2021 Mercedes-Benz E-Class
E 350 4MATIC
58,538 mi
Kenosha, WI
Good Deal
$29,099
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 53,851
- Stock #:
- MA937114P
- VIN:
- W1KZF8EB2MA937114
2021 Mercedes-Benz E-Class
E 350 4MATIC
53,851 mi
Plano, TX
Fair Deal
$29,888
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 56,446
- Stock #:
- MA955936
- VIN:
- W1KZF8EB2MA955936
2021 Mercedes-Benz E-Class
E 350 4MATIC
56,446 mi
Hamilton, NJ
Good Deal
$28,078
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 75,862
- Stock #:
- S26706A
- VIN:
- W1KZF8EB9MA909424
2021 Mercedes-Benz E-Class
E 350 4MATIC
75,862 mi
Charleston, WV
Good Deal
$26,475
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Artico Almond Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,451
- Stock #:
- MP343
- VIN:
- W1KZF8EBXMA904278
2021 Mercedes-Benz E-Class
E 350 4MATIC
30,451 mi
Orlando, FL
Fair Deal
$33,993
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 80,570
- Stock #:
- MA930621
- VIN:
- W1KZF8EB6MA930621
New arrival
2021 Mercedes-Benz E-Class
E 350 4MATIC
80,570 mi
Manchester, NH
Fair Deal
$27,299
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,194
- Stock #:
- M9094PRTL
- VIN:
- W1KZF8EB9MA957876
2021 Mercedes-Benz E-Class
E 350 4MATIC
35,194 mi
Buford, GA
Good Deal
$33,631
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 77,531
- Stock #:
- T26132
- VIN:
- W1KZF8EB1MA917291
2021 Mercedes-Benz E-Class
E 350 4MATIC
77,531 mi
Abilene, TX
Fair Deal
$28,349
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 71,661
- Stock #:
- 879992
- VIN:
- W1KZF8EB4MA879992
2021 Mercedes-Benz E-Class
E 350 4MATIC
71,661 mi
Pine Brook, NJ
Good Deal
$23,992
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 75,514
- Stock #:
- R5088A
- VIN:
- W1KZF8EB7MA903654
Price drop
-$1,000
2021 Mercedes-Benz E-Class
E 350 4MATIC
75,514 mi
Midlothian, VA
Fair Deal
$29,000
$28,000
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,526
- Stock #:
- CP10523
- VIN:
- W1KZF8EB1MA981573
2021 Mercedes-Benz E-Class
E 350 4MATIC
34,526 mi
Pearland, TX
Fair Deal
$33,319
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Cirrus Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,161
- Stock #:
- 27420G
- VIN:
- W1KZF8EB4MA889003
2021 Mercedes-Benz E-Class
E 350 4MATIC
34,161 mi
Highland Park, IL
Good Deal
$30,902
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,410
- Stock #:
- MA920187
- VIN:
- W1KZF8EBXMA920187
2021 Mercedes-Benz E-Class
E 350 4MATIC
40,410 mi
Hudson Oaks, TX
Fair Deal
$32,206
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray (Selenite Grey Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 31,423
- Stock #:
- MB001619
- VIN:
- W1KZF8EB6MB001619
2021 Mercedes-Benz E-Class
E 350 4MATIC
31,423 mi
Ft. Lauderdale, FL
Good Deal
$31,127
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray (Graphite Grey Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 36,657
- Stock #:
- MA964419
- VIN:
- W1KZF8EB5MA964419
2021 Mercedes-Benz E-Class
E 350 4MATIC
36,657 mi
Sterling, VA
Good Deal
$30,998
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Lunar Blue Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,216
- Stock #:
- T09116A
- VIN:
- W1KZF8EB3MA923481
New arrival
2021 Mercedes-Benz E-Class
E 350 4MATIC
41,216 mi
Tiverton, RI
Fair Deal
$35,408
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Grey)
- Transmission:
- Automatic
- Mileage:
- 106,175
- Stock #:
- 956360
- VIN:
- W1KZF8EB2MA956360
New arrival
2021 Mercedes-Benz E-Class
E 350 4MATIC
106,175 mi
Paterson, NJ
Good Deal
$21,644
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Blue
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,714
- Stock #:
- K969003
- VIN:
- W1KZF8EBXMA969003
2021 Mercedes-Benz E-Class
E 350 4MATIC
44,714 mi
Indianapolis, IN
Fair Deal
$31,245
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Blue
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 24,249
- Stock #:
- 997382
- VIN:
- W1KZF8EB8MA997382
New arrival
2021 Mercedes-Benz E-Class
E 350 4MATIC
24,249 mi
Duluth, GA
Fair Deal
$36,088
5.0 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Is this review helpful?
FAQs
How much does the Mercedes-Benz E-Class E 350 4MATIC cost?
The average Mercedes-Benz E-Class E 350 4MATIC costs about $35,920.03. The average price has decreased by -9.5% since last year. The 923 for sale on CarGurus range from $2,200 to $100,895 in price.
How many Mercedes-Benz E-Class E 350 4MATIC vehicles have no reported accidents or damage?
755 out of 923 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz E-Class E 350 4MATIC?
Depending on the engine and options, the Mercedes-Benz E-Class E 350 4MATIC gets between 18 and 28 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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