Used 2021 Mercedes-Benz E-Class E 350 4MATIC for SaleNationwide
69 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 77,930
- Stock #:
- BY70351
- VIN:
- W1KZF8EBXMA873288
2021 Mercedes-Benz E-Class
E 350 4MATIC
77,930 mi
Flushing, NY
Fair Deal
$23,350
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- designo Macchiato Beige/Saddle Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,194
- Stock #:
- M9094PRTL
- VIN:
- W1KZF8EB9MA957876
2021 Mercedes-Benz E-Class
E 350 4MATIC
35,194 mi
Buford, GA
Fair Deal
$32,492
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 31,828
- Stock #:
- MA960028
- VIN:
- W1KZF8EB3MA960028
Price drop
-$1,655
2021 Mercedes-Benz E-Class
E 350 4MATIC
31,828 mi
Bellevue, WA
Great Deal
$33,380
$31,725
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- Automatic
- Mileage:
- 28,131
- Stock #:
- S26000087
- VIN:
- W1KZF8EBXMA937040
2021 Mercedes-Benz E-Class
E 350 4MATIC
28,131 mi
Duluth, GA
Good Deal
$33,819
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 42,790
- Stock #:
- M738798B
- VIN:
- W1KZF8EB7MA880506
New arrival
2021 Mercedes-Benz E-Class
E 350 4MATIC
42,790 mi
North Olmsted, OH
Good Deal
$31,964
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Red
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 79,680
- Stock #:
- 29982A
- VIN:
- W1KZF8EB0MA947964
2021 Mercedes-Benz E-Class
E 350 4MATIC
79,680 mi
Minnetonka, MN
Fair Deal
$26,938
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 86,903
- Stock #:
- 26TI134A
- VIN:
- W1KZF8EB7MA920230
2021 Mercedes-Benz E-Class
E 350 4MATIC
86,903 mi
Troy, MI
Fair Deal
$25,513
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 33,939
- Stock #:
- A948849B
- VIN:
- W1KZF8EB5MA948849
2021 Mercedes-Benz E-Class
E 350 4MATIC
33,939 mi
Chicopee, MA
Fair Deal
$34,767
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 70,200
- Stock #:
- 21e350
- VIN:
- W1KZF8EB9MA948739
2021 Mercedes-Benz E-Class
E 350 4MATIC
70,200 mi
Nyack, NY
Fair Deal
$24,995
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Mileage:
- 37,838
- Stock #:
- 616870A
- VIN:
- W1KZF8EB0MA889175
2021 Mercedes-Benz E-Class
E 350 4MATIC
37,838 mi
Pinellas Park, FL
Good Deal
$33,483
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- designo Cardinal Red Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- designo Macchiato Beige/Saddle Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,346
- Stock #:
- T10983
- VIN:
- W1KZF8EB6MA997641
2021 Mercedes-Benz E-Class
E 350 4MATIC
23,346 mi
Marion, OH
Fair Deal
$35,348
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 36,346
- Stock #:
- 4413
- VIN:
- W1KZF8EB8MA946884
2021 Mercedes-Benz E-Class
E 350 4MATIC
36,346 mi
Clare, MI
Good Deal
$31,074
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,778
- Stock #:
- A935564B
- VIN:
- W1KZF8EB1MA935564
2021 Mercedes-Benz E-Class
E 350 4MATIC
45,778 mi
Nanuet, NY
Fair Deal
$31,385
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Blue
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,714
- Stock #:
- K969003
- VIN:
- W1KZF8EBXMA969003
2021 Mercedes-Benz E-Class
E 350 4MATIC
44,714 mi
Indianapolis, IN
Good Deal
$29,256
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,407
- Stock #:
- 30487
- VIN:
- W1KZF8EBXMA892388
2021 Mercedes-Benz E-Class
E 350 4MATIC
46,407 mi
Yonkers, NY
Fair Deal
$27,734
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,395
- Stock #:
- 8287T
- VIN:
- W1KZF8EB6MA934331
Price drop
-$870
2021 Mercedes-Benz E-Class
E 350 4MATIC
40,395 mi
Cleveland, OH
Fair Deal
$32,113
$31,243
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Artico Almond Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,451
- Stock #:
- MP343
- VIN:
- W1KZF8EBXMA904278
2021 Mercedes-Benz E-Class
E 350 4MATIC
30,451 mi
Orlando, FL
Good Deal
$32,786
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,410
- Stock #:
- MA920187
- VIN:
- W1KZF8EBXMA920187
2021 Mercedes-Benz E-Class
E 350 4MATIC
40,410 mi
Hudson Oaks, TX
Good Deal
$30,165
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray (Graphite Grey Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 64,130
- Stock #:
- B325
- VIN:
- W1KZF8EB0MA902006
2021 Mercedes-Benz E-Class
E 350 4MATIC
64,130 mi
Downers Grove, IL
Fair Deal
$27,985
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- Automatic
- Mileage:
- 29,835
- Stock #:
- MA940955
- VIN:
- W1KZF8EB8MA940955
New arrival
2021 Mercedes-Benz E-Class
E 350 4MATIC
29,835 mi
Bellevue, WA
Fair Deal
$34,580
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Blue
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Tan)
- Transmission:
- Automatic
- Mileage:
- 51,071
- Stock #:
- 18808A
- VIN:
- W1KZF8EB1MA929490
New arrival
2021 Mercedes-Benz E-Class
E 350 4MATIC
51,071 mi
Linden, NJ
Good Deal
$26,737
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Tan)
- Transmission:
- Automatic
- Mileage:
- 65,385
- Stock #:
- 3378
- VIN:
- W1KZF8EB8MA905509
Price drop
-$3,000
2021 Mercedes-Benz E-Class
E 350 4MATIC
65,385 mi
Pottstown, PA
Great Deal
$26,476
$23,476
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Tan)
- Transmission:
- Automatic
- Mileage:
- 52,875
- Stock #:
- Y8266A
- VIN:
- W1KZF8EB2MA909376
2021 Mercedes-Benz E-Class
E 350 4MATIC
52,875 mi
Columbus, OH
Good Deal
$27,898
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 75,922
- Stock #:
- 909424
- VIN:
- W1KZF8EB9MA909424
2021 Mercedes-Benz E-Class
E 350 4MATIC
75,922 mi
Columbus, OH
Good Deal
$25,398
5.0 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Is this review helpful?
FAQs
How much does the Mercedes-Benz E-Class E 350 4MATIC cost?
The average Mercedes-Benz E-Class E 350 4MATIC costs about $35,967.15. The average price has decreased by -9.2% since last year. The 1040 for sale on CarGurus range from $3,298 to $80,418 in price.
How many Mercedes-Benz E-Class E 350 4MATIC vehicles have no reported accidents or damage?
844 out of 1040 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz E-Class E 350 4MATIC?
Depending on the engine and options, the Mercedes-Benz E-Class E 350 4MATIC gets between 18 and 28 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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