Used 2021 Mercedes-Benz E-Class for Sale nearMilwaukee, WI

Compare 2021 Mercedes-Benz E-Class Trims in Milwaukee, WI

The 2021 E-Class offers a range of trims from budget-friendly AWD options to luxurious coupes, catering to diverse preferences and budgets.

• Starting at $25,955
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

Missing data displayed as "—".

Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want a luxury sedan experience without the AWD price premium. It's a great value option in the lineup.

• Avg. market price: $30,762 (updated weekly)
• MPG/MPGe: 22 city / 31 hwy
• Inventory: 54 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the pick for shoppers who want all-wheel drive without breaking the bank. It's the most popular trim, offering a great balance of features.

• Avg. market price: $25,955 (updated weekly)
• MPG/MPGe: 22 city / 30 hwy
• Inventory: 105 listings — widest selection in the lineup
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is the pick for shoppers who want a powerful and luxurious sedan without going for the top-tier models.

• Avg. market price: $30,762 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 20 listings
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is the pick for shoppers who want a stylish coupe with luxury features without the AWD cost.

• Avg. market price: $30,762 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 13 listings — lower availability; may limit negotiating room
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is the pick for shoppers who want a premium coupe experience with all-wheel drive.

• Avg. market price: $30,762 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 18 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is the pick for shoppers who want a luxurious convertible experience without the AWD price.

• Avg. market price: $40,376 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 14 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

E 450 4MATIC Cabriolet AWD — "Who It's For"

The E 450 4MATIC Cabriolet AWD is the pick for shoppers who want a luxurious convertible with all-wheel drive.

• Avg. market price: $30,762 (updated weekly)
• MPG/MPGe: 23 city / 29 hwy
• Inventory: 7 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Cabriolet AWD listings

AMG E 63 S Sedan 4MATIC — "Who It's For"

The AMG E 63 S Sedan 4MATIC is the pick for shoppers who want high performance and luxury in one package.

• Avg. market price: $30,762 (updated weekly)
• MPG/MPGe: 16 city / 23 hwy
• Inventory: 18 listings — lower availability; may limit negotiating room
• View AMG E 63 S Sedan 4MATIC listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 105 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 350 4MATIC

At $25,955 avg market price — below the lineup median of $30,762 — it's the most accessible entry point.

Browse E 350 4MATIC listings

Best for Fuel Economy — E 450 Coupe RWD

The E 450 Coupe RWD offers the best fuel economy in the lineup with 23 MPG city and 31 MPG highway.

Browse E 450 Coupe RWD listings

These recommendations are based on CarGurus' proprietary market data from September 2, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2021 Mercedes-Benz E-Class cost?

Prices have softened 14.80% compared to this time last year, making it a favorable time to shop this model year.

There are 802 listings available, which suggests you should have a workable range of choices.

If you find a listing below $35,967.92, that's toward the low end of the year-round range and worth acting on quickly.

Is the 2021 Mercedes-Benz E-Class a good car?

Yes — the 2021 Mercedes-Benz E-Class earns a 4.7/5 user rating and an 8.33/10 expert rating. The model scores 10/10 across Technology and Safety.

Owners consistently praise its blend of luxury, performance, and beautiful design, along with the powerful engine and comfortable interior. The review feedback also points to advanced features and a premium feel as recurring strengths.

The trade-offs are that it can feel overpriced, and some shoppers may miss features such as active lane keeping assist. The overview also frames it as a highly versatile luxury car, so it fits you best if you want one vehicle that can cover comfort, style, and capability without giving up refinement.

Only 32.2% of listings are priced as good or great deals, so the market rewards selective shopping.

Is the 2021 Mercedes-Benz E-Class reliable?

Owners rate it 4.7/5, a strong signal of long-term satisfaction.

Review feedback points to a car that owners trust for its luxury, performance, and comfortable daily use, with the kind of broad appeal that usually supports confidence over time. The expert evaluation also describes the E-Class as a quiet and excellent choice for a car this size, which reinforces its dependability as a long-term companion.

The 48-volt hybrid setup is designed to support smoother starts, more frequent engine shutoff, and reduced emissions, which helps the powertrain feel modern and efficient in use. For used buyers, the main long-term ownership risk is that this is a complex luxury car, so deferred maintenance and missing equipment can matter more than they would on a simpler vehicle.

What should I look for when buying a used 2021 Mercedes-Benz E-Class?

Accident-free inventory is solid at 75.9% — always verify the vehicle history report.

You should still check the history report carefully, because a clean listing percentage does not replace a proper records review. Prioritize a pre-purchase inspection that focuses on condition, equipment operation, and signs of deferred maintenance. Since advanced safety features are not standard, make sure the specific car you are considering has the equipment you want.

Key things to evaluate:

• Trim level: The cabin is richly appointed even in lower trims, but the base setup can miss some of the more premium touches you may expect from a luxury car.
• Powertrain: You can choose from multiple engines, including a 2.0-liter turbo four-cylinder and electrified inline-six powertrains; the four-cylinder is described as underwhelming, while the inline-six is quiet and excellent.
• Safety package: Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard, while other driver-assist features remain optional.
• Infotainment: The system uses dual 12-inch screens, MBUX software, touch input, natural voice processing, and online search; Apple CarPlay and Android Auto are standard but not wireless, and OTA updates are not included.
• Fuel efficiency: The E53 sedan is rated at 25 mpg combined, 22 mpg city, and 29 mpg highway; the E63 sedan is rated at 18 mpg combined, 16 mpg city, and 23 mpg highway. The E450 4Matic sedan returns 26 mpg combined, 23 mpg city, and 30 mpg highway, while the E350 4Matic sedan returns 25 mpg combined, 22 mpg city, and 30 mpg highway.

Which 2021 Mercedes-Benz E-Class trim should I buy?

The 2021 Mercedes-Benz E-Class is offered in 13 trim levels: E350, E350 4Matic, E450 4Matic, E450 coupe, E450 convertible, AMG E53, AMG E53 coupe, AMG E53 convertible, AMG E63 S, AMG E63 S wagon, E350 sedan, E450 sedan, and E63 sedan.

Here's the short version:

• E350: This is the entry point if you want the E-Class experience at the lowest starting point, but the four-cylinder powertrain is the least convincing choice in the lineup.
• E350 4Matic: This is the better-value pick if you want all-weather traction and a more complete daily-driver setup without moving into the pricier six-cylinder models.
• E450 4Matic: This is the sweet spot for many shoppers because it pairs the stronger electrified inline-six with a more polished, quiet, and satisfying driving experience.
• E450 coupe: Choose this if you want the E-Class formula in a two-door body and are comfortable giving up some practicality for style.
• E450 convertible: Pick this if open-air luxury matters most and you want the most relaxed, upscale version of the E-Class personality.
• AMG E53: This is the best choice if you want the strongest blend of speed, handling precision, and comfort, plus the rear-biased AWD and variable-rate air suspension.
• AMG E53 coupe: Choose this if you want the AMG E53 character in a more dramatic two-door package.
• AMG E53 convertible: Pick this if you want the AMG E53’s performance with top-down appeal.
• AMG E63 S: This is the extreme performance choice, with a hand-built V8, 603 hp, and a much more serious chassis setup.
• AMG E63 S wagon: Choose this if you want the wildest version of the E-Class with wagon practicality.
• E350 sedan: This is the most straightforward sedan choice, but it is best only if price matters more than power.
• E450 sedan: This is the best-value sedan for most buyers because it delivers the strongest balance of refinement, performance, and everyday usability.
• E63 sedan: Choose this only if you want the most powerful sedan and are willing to pay for it.

Advanced safety features are not standard, so check each trim carefully for the driver-assistance equipment you want.

Is now a good time to buy a used 2021 Mercedes-Benz E-Class?

This is a moderate market for selective buyers, with enough inventory to shop carefully and enough price softness to create opportunities.

• Deal availability: 32.2% of listings are priced as good or great deals.
• Inventory: There are 802 listings available.
• Price trend: Prices have softened 14.80% compared with last year.
• Clean inventory: 75.9% of listings are accident-free.

If you find a listing below $35,967.92, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Mercedes-Benz E-Class's resale value?

The current average of $35,920 sits slightly below last year's $42,158.

That price movement suggests the market has already absorbed a meaningful amount of depreciation, which can help future resale stability if you buy at the right number. If you purchase near the lower end of the current range, you may reduce the amount of value left to lose. Strong equipment, clean history, and desirable powertrains should matter more when it is time to sell.

Vehicles with strong owner satisfaction ratings, like this model year's 4.7/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Mercedes-Benz E-Class safe?

The 2021 E-Class sedan and wagon earned a five-star overall rating from NHTSA, with five-star ratings in frontal and side crash tests and for rollover vulnerability, though the driver's side received a four-star rating in the frontal crash test. The 2020 E-Class sedan was rated a Top Safety Pick+ by IIHS.

It earns a 10/10 safety score from our experts.

Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Other driver-assistance features remain optional, so you should confirm the exact safety equipment on any used example you consider.

Should I buy a 2021 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 32.2% of listings are priced as good or great deals.
• Accident-free inventory is solid at 75.9% — always verify the vehicle history report.
• Price trend: Prices have softened 14.80% compared with last year.
• Owners rate it 4.7/5 — a strong satisfaction signal.
• It adds a mid-cycle update for the infotainment system, engines, and exterior styling.

Consider the 2020 if:

• At $30,553, the 2020 costs less than the current year's $35,920 average.
• It offers a stylish, tech-rich luxury experience with a new base engine.

Consider the 2022 if:

• At $39,806, the 2022 costs more than the current year's $35,920 average.
• It keeps the refreshed formula while adding standard automatic high beams and more standard convenience features.

The bottom line: If you want the best balance of freshness, features, and current pricing, the 2021 is the strongest target. If your budget is tighter, the 2020 can save you money, while the 2022 makes sense if you want a slightly newer model and do not mind paying more.

These recommendations are based on CarGurus' proprietary market data from September 4, 2026, CarGurus experts' opinions, and generative AI.