Used 2022 Mercedes-Benz E-Class for SaleNationwide
1,072 vehicles found
See the total price upfront.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 36,635
- Stock #:
- UN8660
- VIN:
- W1KZF6BB3MA947448
-$4,050
2021 Mercedes-Benz E-Class
AMG 53 E Sedan 4MATIC
36,635 mi
$49,994
$45,944
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 56,941
- Stock #:
- G2061-1
- VIN:
- W1KZF8DB2PB115400
-$1,747
2023 Mercedes-Benz E-Class
E 350 RWD
56,941 mi
$34,912
$33,165
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 35,924
- Stock #:
- X43795A
- VIN:
- W1KZF6BB2MA902064
2021 Mercedes-Benz E-Class
AMG 53 E Sedan 4MATIC
35,924 mi
$48,077
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 10,721
- Stock #:
- Z607206A
- VIN:
- W1K1J5KB3PF196042
2023 Mercedes-Benz E-Class
E 450 4MATIC
10,721 mi
$54,636
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Nautical Blue
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Nut Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 16,238
- Stock #:
- P102197
- VIN:
- W1KZF8DBXPB102197
2023 Mercedes-Benz E-Class
E 350 RWD
16,238 mi
$40,822
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Mojave Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,151
- Stock #:
- UCL6707A
- VIN:
- W1KZF8DB4MA974019
2021 Mercedes-Benz E-Class
E 350 RWD
44,151 mi
$30,686
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 27,861
- Stock #:
- PB10133
- VIN:
- W1KZF8DB6NB076095
2022 Mercedes-Benz E-Class
E 350 RWD
27,861 mi
$35,843
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Blue
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,990
- Stock #:
- MZI1177A
- VIN:
- W1KZF8DB5NB080896
-$990
2022 Mercedes-Benz E-Class
E 350 RWD
58,990 mi
$31,988
$30,998
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 67,716
- Stock #:
- 9238
- VIN:
- W1KZF6BB3NB013379
2022 Mercedes-Benz E-Class
AMG E 53 Sedan 4MATIC
67,716 mi
$43,478
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,051
- Stock #:
- BP1184A
- VIN:
- W1KZF8EB0NB068086
-$889
2022 Mercedes-Benz E-Class
E 350 4MATIC
58,051 mi
$32,687
$31,798
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- Automatic
- Mileage:
- 42,779
- Stock #:
- PTM7080
- VIN:
- W1KZF6BB4MA927080
2021 Mercedes-Benz E-Class
AMG 53 E Sedan 4MATIC
42,779 mi
$48,195
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 19,995
- Stock #:
- C226231N
- VIN:
- W1KZF8DB6NB090613
2022 Mercedes-Benz E-Class
E 350 RWD
19,995 mi
$31,940
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 27,369
- Stock #:
- P1053
- VIN:
- W1KZF8DB4NB089430
-$1,001
2022 Mercedes-Benz E-Class
E 350 RWD
27,369 mi
$34,987
$33,986
CarGurus Analysis:
2022 Mercedes-Benz E-Class
With 1,071 currently listed for sale and an average price of $40,899.00, 33.3% of 2022 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz E-Class 5 / 5 stars.
85.3% of 2022 E-Class models on CarGurus are accident free.
The 2022 Mercedes-Benz E-Class features a variety of body styles, including coupe, convertible, sedan, and station wagon, and offers advanced technology with the MBUX infotainment system.
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,248
- Stock #:
- PD2750
- VIN:
- W1KZF8EB1NB043858
-$1,227
2022 Mercedes-Benz E-Class
E 350 4MATIC
49,248 mi
$33,226
$32,377
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Convertible
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray (Selenite Grey Metallic)
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 53,771
- Stock #:
- MF151095
- VIN:
- W1K1K6BBXMF151095
2021 Mercedes-Benz E-Class
AMG E 53 Cabriolet 4MATIC
53,771 mi
$45,918
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black Mb-)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 64,084
- Stock #:
- 051104
- VIN:
- W1KZF8DBXNB051104
2022 Mercedes-Benz E-Class
E 350 RWD
64,084 mi
$29,234
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 24,732
- Stock #:
- GU0983
- VIN:
- W1KZF8EB0NB037761
2022 Mercedes-Benz E-Class
E 350 4MATIC
24,732 mi
$37,348
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,154
- Stock #:
- R120828
- VIN:
- W1KZF8DBXPB120828
2023 Mercedes-Benz E-Class
E 350 RWD
46,154 mi
$40,464
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,253
- Stock #:
- NNB072344T
- VIN:
- W1KZF8DB3NB072344
2022 Mercedes-Benz E-Class
E 350 RWD
36,253 mi
$34,688
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 29,962
- Stock #:
- LPB144861
- VIN:
- W1KZF5KB5PB144861
2023 Mercedes-Benz E-Class
E 450 4MATIC
29,962 mi
$48,221
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Convertible
- Doors:
- 2 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 362 hp 3L I6
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,198
- Stock #:
- U181682
- VIN:
- W1K1K5JB3NF181682
2022 Mercedes-Benz E-Class
E 450 Cabriolet RWD
46,198 mi
$51,504
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 59,510
- Stock #:
- PNB086473
- VIN:
- W1KZF6BB8NB086473
2022 Mercedes-Benz E-Class
AMG E 53 Sedan 4MATIC
59,510 mi
$44,689
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 50,248
- Stock #:
- DB078310
- VIN:
- W1KZF8DB5NB078310
2022 Mercedes-Benz E-Class
E 350 RWD
50,248 mi
$27,223
CarGurus Analysis: 2022 Mercedes-Benz E-Class
overall
Summary
With 1,071 currently listed for sale and an average price of $40,899.00, 33.3% of 2022 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz E-Class 5 / 5 stars.
85.3% of 2022 E-Class models on CarGurus are accident free.
The 2022 Mercedes-Benz E-Class features a variety of body styles, including coupe, convertible, sedan, and station wagon, and offers advanced technology with the MBUX infotainment system.
Why it stands out
The 2022 Mercedes-Benz E-Class stands out in the luxury vehicle segment due to its impressive versatility and high-quality craftsmanship. Available in multiple body styles, including coupe, convertible, sedan, and station wagon, it caters to a wide range of preferences and needs. The E-Class is equipped with advanced technology, highlighted by the MBUX infotainment system, which features two high-resolution 12.3-inch screens and offers seamless smartphone integration. The vehicle's performance is equally commendable, with options for turbocharged four-cylinder and six-cylinder engines, ensuring a balance of power and efficiency. Additionally, the E-Class is designed with luxury in mind, featuring high-end materials and comfort-focused amenities, such as heated seats and a sophisticated sound system. While it may not be the most cost-effective option in its class, the E-Class delivers a driving experience that is both engaging and refined, making it a compelling choice for luxury car buyers.
Other model years to consider
- Average price: $23,544.00
- Good/great deal percentage: 35.3%
- User rating: 4.76 / 5
- Total listings: 1,395
- Average price: $31,571.00
- Good/great deal percentage: 34.7%
- User rating: 5 / 5
- Total listings: 998
- Average price: $18,694.00
- Good/great deal percentage: 34.8%
- User rating: 4.78 / 5
- Total listings: 1,334
This analysis is based on CarGurus' proprietary market data from July 6, 2026, CarGurus experts' opinions, and generative AI.
5.0 Overall rating
Filter by rating
Jim S
Reviewed a 2022 Mercedes-Benz E-Class on Mar 6, 2025
The E-class is the midsize line of Mercedes cars, so it’s fine for all sizes except for very tall and large people. The new inline six cylinder is my favorite engine because it has plenty of power and is fuel efficient. Overall, the quality is here and has been for years.
Anonymous
Reviewed a 2022 Mercedes-Benz E-Class on Jul 12, 2024
Great value. 39K with 14K miles and in great condition with premium package. Took it to the Mercedes dealer for inspection and they said it was in great shape (tires, brakes, belts, filters, oil, fluid level, electronics, and even spark plugs). The interior was in pristine condition and the exterior is just as perfect.
Jim S
Reviewed a 2022 Mercedes-Benz E-Class on Mar 7, 2025
The E-class Mercedes Is the midsize car segment, and is large enough for many people who are not over 6’ 6” or more than 380 pounds in my estimation. Quality is noticed in interior seating and fit and finish. The relatively new Inline six cylinder engine has enough power with above average fuel economy. Other engines are available in four cylinder and eight cylinder variants.
Bill F
Reviewed a 2022 Mercedes-Benz E-Class on Jan 7, 2023
First class, quality material and build! You know maintenance is expensive going into it, but it is what it is.
2022 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| E 450 4MATIC Coupe AWD | $68,600 |
| AMG E 53 Coupe 4MATIC | $77,600 |
| E 450 Cabriolet RWD | $73,250 |
| E 450 Coupe RWD | $66,100 |
| E 450 4MATIC Sedan AWD | $62,750 |
| AMG E 53 Sedan 4MATIC | $75,000 |
| E 350 4MATIC | $57,450 |
| E 350 RWD | $54,950 |
2022 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2022 Mercedes-Benz E-Class prices has changed over time.
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