Used 2022 Mercedes-Benz E-Class for Sale near Illinois

Compare 2022 Mercedes-Benz E-Class Trims

The E-Class offers a range of trims from budget-friendly options to luxurious performance models, catering to various preferences and needs.

• Starting at $32,461
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

Missing data displayed as "—".

Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want a luxury sedan experience without paying for all-wheel drive. It's the most budget-friendly option in the lineup.

• Avg. market price: $32,461 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 538 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the choice for those who want all-wheel drive without a significant price increase. It's also the most popular trim in the lineup.

• Avg. market price: $34,086 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 882 listings
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is ideal for buyers seeking a sportier drive with all-wheel capability. However, availability is limited.

• Avg. market price: $42,423 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 102 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is perfect for those who desire a stylish coupe with luxury features without the AWD premium. Availability is limited.

• Avg. market price: $39,559 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 63 listings — lower availability; may limit negotiating room
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is for buyers wanting a luxurious coupe with all-wheel drive. Limited availability may affect options.

• Avg. market price: $41,902 (updated weekly)
• MPG/MPGe: 21 city / 30 hwy
• Inventory: 60 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is ideal for those seeking a luxurious convertible experience without the AWD cost. Availability is limited.

• Avg. market price: $52,115 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 58 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

AMG E 53 Sedan 4MATIC — "Who It's For"

The AMG E 53 Sedan 4MATIC is for performance enthusiasts who want a high-powered luxury sedan. Limited availability may affect options.

• Avg. market price: $50,700 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 48 listings — lower availability; may limit negotiating room
• View AMG E 53 Sedan 4MATIC listings

E 450 4MATIC Cabriolet AWD — "Who It's For"

The E 450 4MATIC Cabriolet AWD is perfect for those wanting a luxurious convertible that can handle all weather conditions. Availability is limited.

• Avg. market price: $48,782 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 36 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Cabriolet AWD listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 882 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 350 RWD

At $32,461 avg market price — below the lineup median of $42,162 — it's the most accessible entry point.

Browse E 350 RWD listings

Best for Fuel Economy — E 350 RWD

The E 350 RWD offers the best fuel economy in the lineup at 23/31 MPG/MPGe.

Browse E 350 RWD listings

These recommendations are based on CarGurus' proprietary market data from September 2, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2022 Mercedes-Benz E-Class cost?

Prices have softened 6.40% compared to this time last year, making it a favorable time to shop this model year.

With 1,032 listings available, you have a decent amount of inventory to compare across trims and body styles.

If you find a listing below $40,128.07, that's toward the low end of the year-round range and worth acting on quickly.

Is the 2022 Mercedes-Benz E-Class a good car?

Yes — the 5/5 user rating lines up with an 8.17/10 expert rating. The standout strength is Safety at 10/10.

The 2022 E-Class is positioned as a refined luxury car with rare body-style variety, especially in Cabriolet form, and it continues to lean on polished character rather than major reinvention. That makes it a strong fit if you want upscale appeal, useful standard equipment, and a broad range of configurations rather than a dramatic redesign.

30.2% of listings are marked as good or great deals, which gives you some room to shop selectively.

Is the 2022 Mercedes-Benz E-Class reliable?

Owners rate it 5/5, a strong signal of long-term satisfaction.

The 2022 E-Class is described as a polished, upscale luxury car, and the expert review also points to a robust turbocharged six-cylinder setup with EQ Boost mild-hybrid technology that helps improve both power output and efficiency. The model’s overall character suggests a car built to deliver comfort and refinement over the long haul, and Mercedes’ standard maintenance coverage can help reduce early ownership friction when it applies to your specific vehicle.

For a used buyer, the main long-term risk is paying luxury-car money for a car that may have been heavily optioned or driven hard, so condition and service history matter a lot.

What should I look for when buying a used 2022 Mercedes-Benz E-Class?

Accident-free inventory is solid at 84.5% — always verify the vehicle history report.

You should still check the history report carefully, because a clean listing percentage does not replace a proper paper trail. Prioritize a pre-purchase inspection that focuses on the cabin electronics, convertible-top operation if applicable, and the condition of the wheels, tires, and suspension. If you are shopping an AMG version, pay extra attention to how the car drives under load and whether all performance and comfort systems work as intended.

Key things to evaluate:

• Trim level: The lineup spans coupe, convertible, sedan, and station wagon body styles, and the AMG E53 stands out with AMG styling, larger wheels, a convertible top, and a more dramatic cabin presentation. Base E350 models are more understated, while higher-spec versions add the richer look and feel that make the E-Class feel special.
• Powertrain: Sedans come with an E350 turbocharged four-cylinder, while E450 versions use a turbo 3.0-liter inline-six with EQ Boost 48-volt mild-hybrid technology. AMG E53 models use a more powerful version of the E450 engine, and the lineup no longer includes V8 power.
• Safety package: Standard equipment includes forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, rear cross-traffic alert, Mercedes Pre Safe, and Pre Safe Sound. The Driver Assistance Package adds adaptive cruise control with Active Speed Limit Assist, Active Steering Assist, front automatic braking for cross traffic, Evasive Steering Assist, Active Lane Keeping Assist, Active Blind Spot Assist, Active Emergency Stop Assist, and Pre Safe Plus.
• Infotainment: The cabin uses Mercedes-Benz User Experience with two 12.3-inch screens, Apple CarPlay, Android Auto, WiFi service, and an augmented reality navigation overlay. A head-up display is also available.
• Fuel efficiency: EQ Boost is designed to improve both power output and efficiency.

Which 2022 Mercedes-Benz E-Class trim should I buy?

The 2022 Mercedes-Benz E-Class is offered in 3 trim levels: E350, E450, AMG E53.

Here's the short version:

• E350: This is the most accessible way into the lineup, and it gives you the turbocharged four-cylinder setup in a more understated package. It makes sense if you want the E-Class experience without chasing the pricier performance and appearance upgrades.
• E450: This is the best-value trim for many shoppers because it adds the turbo 3.0-liter inline-six with EQ Boost mild-hybrid technology and keeps the car’s refined character intact. If you want stronger acceleration and a more satisfying all-around luxury feel, this is the one to target.
• AMG E53: Choose this if you want the most performance-focused version in the lineup, with AMG tuning, more aggressive styling, and the strongest engine output discussed here. It suits you best if you care more about speed and presence than value.

The Driver Assistance Package is a worthwhile safety upgrade if you find a car without it.

Is now a good time to buy a used 2022 Mercedes-Benz E-Class?

This looks like a moderate, selective buyer’s market, so you can shop carefully and still find worthwhile listings.

• Deal availability: 30.2% of listings are priced as good or great deals.
• Inventory: There are 1,032 listings available.
• Price trend: Prices have softened 6.40% compared with last year.
• Clean inventory: 84.5% of listings are accident-free.

If you find a listing below $40,128.07, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz E-Class's resale value?

The current average of $40,373 sits slightly below last year's $43,133.

That price movement suggests the market has already adjusted downward, which can help you buy more confidently today. For a future seller, it also means your resale outcome will depend heavily on condition, mileage, and equipment, because the model is competing in a luxury segment where buyers are selective.

If you keep the car well maintained and avoid neglecting cosmetic or mechanical issues, you should be in a better position when it is time to sell. Strong presentation matters especially here because shoppers in this class often compare multiple similarly equipped examples.

Vehicles with strong owner satisfaction ratings, like this model year's 5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz E-Class safe?

It earns a 10/10 safety score from our experts.

The E-Class comes with standard forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, rear cross-traffic alert, Mercedes Pre Safe, and Pre Safe Sound. The Cabriolet also adds pop-up rollbars for rollover protection, and Active Parking Assist plus a surround-view camera system are standard on the AMG E53.

Most of the more advanced driver aids are bundled into the extra-cost Driver Assistance Package, which adds adaptive cruise control with Active Speed Limit Assist, Active Steering Assist, front automatic braking for cross traffic, Evasive Steering Assist, Active Lane Keeping Assist, Active Blind Spot Assist, Active Emergency Stop Assist, and Pre Safe Plus. That package is a meaningful upgrade if you want the fullest safety tech suite.

Should I buy a 2022 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 30.2% of listings are priced as good or great deals.
• Accident-free inventory is solid at 84.5% — always verify the vehicle history report.
• Price trend: Prices have softened 6.40% compared with last year.
• Owners rate it 5/5 — a strong satisfaction signal.
• The 2022 lineup keeps the refreshed look and standard automatic high-beam headlights while dropping V8 and AMG E63 variants.

Consider the 2021 if:

• At $36,681, the 2021 costs less than the current year's $40,373 average.
• It offers broad body-style and engine variety with a practical, versatile character.

The bottom line: If you want the newer model-year pricing trend, strong safety, and a refreshed feature set, the 2022 is the better primary choice. If your priority is spending less up front, the 2021 is the smarter price-sensitive alternative, especially if you find one in excellent condition.

These recommendations are based on CarGurus' proprietary market data from August 28, 2026, CarGurus experts' opinions, and generative AI.