Used 2021 Mercedes-Benz E-Class for Sale near Ohio

Compare 2021 Mercedes-Benz E-Class Trims

The E-Class offers a range of trims from budget-friendly options to luxurious performance models, catering to various preferences and needs.

• Starting at $28,489
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

Missing data displayed as "—".

Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want a luxury sedan experience without the higher price of AWD options.

• Avg. market price: $28,489 (updated weekly)
• MPG/MPGe: 22 city / 31 hwy
• Inventory: 517 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the choice for those seeking all-wheel drive without a significant price increase, making it a popular option.

• Avg. market price: $29,718 (updated weekly)
• MPG/MPGe: 22 city / 30 hwy
• Inventory: 940 listings
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is ideal for buyers wanting more power and luxury features, though availability is limited.

• Avg. market price: $36,117 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 90 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is perfect for those who desire a stylish coupe with luxury features without going for the AWD option.

• Avg. market price: $34,059 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 70 listings — lower availability; may limit negotiating room
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is for buyers wanting a sporty coupe with all-wheel drive, though availability is limited.

• Avg. market price: $43,714 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 57 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is ideal for those seeking a luxurious convertible experience without the AWD premium.

• Avg. market price: $45,604 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 62 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

E 450 4MATIC Cabriolet AWD — "Who It's For"

The E 450 4MATIC Cabriolet AWD is for buyers wanting a luxurious convertible with all-wheel drive, though availability is limited.

• Avg. market price: $40,745 (updated weekly)
• MPG/MPGe: 23 city / 29 hwy
• Inventory: 39 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Cabriolet AWD listings

AMG E 63 S Sedan 4MATIC — "Who It's For"

The AMG E 63 S Sedan 4MATIC is the choice for performance enthusiasts seeking a high-powered luxury sedan.

• Avg. market price: $78,038 (updated weekly)
• MPG/MPGe: 16 city / 23 hwy
• Inventory: 76 listings — lower availability; may limit negotiating room
• View AMG E 63 S Sedan 4MATIC listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 940 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 350 RWD

At $28,489 avg market price — below the lineup median of $38,431 — it's the most accessible entry point.

Browse E 350 RWD listings

Best for Fuel Economy — E 450 Coupe RWD

The E 450 Coupe RWD offers the best fuel economy in the lineup with 23 MPG city and 31 MPG highway.

Browse E 450 Coupe RWD listings

These recommendations are based on CarGurus' proprietary market data from September 24, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2021 Mercedes-Benz E-Class cost?

Prices have softened 13.35% compared to this time last year, making it a favorable time to shop this model year.

There are 804 listings available, which gives you a decent amount of inventory to compare before you buy.

Is the 2021 Mercedes-Benz E-Class a good car?

Yes — the 2021 Mercedes-Benz E-Class earns a 4.7/5 user rating and an 8.33/10 expert rating. The model scores 10/10 across Technology and Safety.

Owners consistently praise the blend of luxury, performance, and beautiful design, along with the comfortable interior and advanced features. The E-Class also stands out for its powerful engine and the sense that it delivers a premium experience across multiple body styles and powertrains.

The main trade-offs are that it can feel overpriced and that advanced safety features are not standard. It is best suited to you if you want a versatile luxury car that can be configured for comfort, speed, or efficiency rather than a stripped-down value play.

With 33.8% of listings marked as good or great deals, there is still room to shop selectively.

Is the 2021 Mercedes-Benz E-Class reliable?

Owners rate it 4.7/5, a strong signal of long-term satisfaction.

The owner feedback also points to a car that feels reliable and dependable in everyday use, with many drivers describing it as a vehicle they can count on for the long haul. The expert notes reinforce that impression by emphasizing the E-Class’s refined, quiet powertrains and its ability to deliver smooth, repeatable performance without feeling strained.

If you are buying used, the biggest long-term ownership risk is less about basic durability and more about how well the car was maintained and optioned, since complexity and premium features can raise repair exposure over time.

What should I look for when buying a used 2021 Mercedes-Benz E-Class?

Accident-free inventory is solid at 75.6% — always verify the vehicle history report.

You should start with a history report, then prioritize a pre-purchase inspection that checks electronics, suspension behavior, and any optional driver-assistance equipment. Because this car can be heavily optioned, condition matters not just for cosmetics but also for how well the technology and comfort features still work.

Key things to evaluate:

• Trim level: The cabin is richly appointed even in lower trims, but the base setup can leave you wanting if you expect a fully loaded luxury experience. The E-Class also spans sedan, wagon, coupe, and convertible body styles, so you should compare equipment carefully rather than assuming every version feels equally upscale.
• Powertrain: You get multiple engine choices, including a revised 2.0-liter turbo four-cylinder, electrified inline-six powertrains, and high-output AMG variants. The six-cylinder setup is the sweet spot for smoothness and strength, while the base four-cylinder is described as underwhelming for a car in this price range.
• Safety package: Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Other driver-assist features are optional, so you should confirm exactly which systems are fitted on the car you are considering.
• Infotainment: The car uses MBUX with dual 12-inch screens, touch and swipe controls, natural voice processing, and online search. Apple CarPlay and Android Auto are standard, but they are not wireless, and the system does not update over the air.
• Fuel efficiency: The E350 4Matic sedan returns 25 mpg combined, and the E450 4Matic sedan returns 26 mpg combined. The AMG E53 sedan is rated at 25 mpg combined, while the AMG E63 sedan is rated at 18 mpg combined.

Which 2021 Mercedes-Benz E-Class trim should I buy?

The 2021 Mercedes-Benz E-Class is offered in 13 trim levels: E350, E450, AMG E53, AMG E63 S, sedan, wagon, coupe, convertible, 4Matic, Luxury package, Sport package, AMG models, and E63 S.

Here's the short version:

• E350: This is the entry point, but it is also the trim most likely to leave you wanting more from the powertrain. It makes sense if you want the E-Class experience at the lowest starting point, but the four-cylinder is the least compelling engine in the lineup.
• E450: This is the best-value choice for most shoppers because it brings the smoother electrified inline-six and a stronger overall balance of refinement and performance. If you want the most satisfying everyday E-Class without jumping into AMG territory, this is the one to target.
• AMG E53: Choose this if you want sharper acceleration, rear-biased AWD, and a more athletic personality without going all the way to the V8 model. It adds serious performance while still preserving much of the E-Class comfort.
• AMG E63 S: This is the halo choice if you want maximum power and the most dramatic driving experience. It is far more specialized than the rest of the lineup, so it makes sense only if performance is your top priority.

Some safety features are optional, and some are not available from any other automaker, so verify the exact driver-assistance package before you buy.

Is now a good time to buy a used 2021 Mercedes-Benz E-Class?

This is a moderate market for selective buyers, so you can shop with some leverage if you focus on the right listing.

• Deal availability: 33.8% of listings are priced as good or great deals.
• Inventory: There are 804 listings available.
• Price trend: Prices have softened 13.35% compared with last year.
• Clean inventory: 75.6% of listings are accident-free.

If you find a listing below $35,907, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Mercedes-Benz E-Class's resale value?

The current average of $36,344 sits slightly below last year's $41,943.

That decline suggests the market has already adjusted downward, which can help you buy more confidently now but may also limit near-term upside if you plan to resell soon. For a future seller, the key takeaway is that the E-Class is holding at a more accessible price point than it did a year ago, so depreciation pressure has already done some of the work.

Because the model still carries strong brand appeal and broad buyer interest, well-kept examples should remain easier to move than neglected ones. Vehicles with strong owner satisfaction ratings, like this model year's 4.7/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Mercedes-Benz E-Class safe?

The 2021 E-Class sedan and wagon earned a five-star overall rating from NHTSA, with five-star ratings in frontal, side, and rollover testing, though the driver's side received a four-star rating in the frontal crash test.

It earns a 10/10 safety score from our experts.

Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Other driver-assistance features are optional, so you should confirm the exact equipment on any used example you are considering.

Should I buy a 2021 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 33.8% of listings are priced as good or great deals.
• Accident-free inventory is solid at 75.6% — always verify the vehicle history report.
• Price trend: Prices have softened 13.35% compared with last year.
• Owners rate it 4.7/5 — a strong satisfaction signal.
• It brings a mid-cycle update to the infotainment system, engines, and exterior styling.

Consider the 2020 if:

• At $30,575, the 2020 costs less than the current year's $36,344 average.
• It offers a broad, upscale lineup with a new base engine and strong technology.

Consider the 2022 if:

• At $39,523, the 2022 costs more than the current year's $36,344 average.
• It carries forward the refresh and adds standard convenience features like automatic high beams.

The bottom line: If you want the best balance of updated tech, strong owner satisfaction, and a softer used-car price than last year, the 2021 is the smart target. If your budget is tighter, the 2020 can save you money, while the 2022 makes sense if you want the newer carryover updates and do not mind paying more.

These recommendations are based on CarGurus' proprietary market data from September 22, 2026, CarGurus experts' opinions, and generative AI.