Used 2021 Mercedes-Benz S-Class for Sale Nationwide
796 results
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 798 currently listed for sale and an average price of $62,181.00, 32.0% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.7% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features an updated infotainment system, advanced ride comfort with a new air suspension, and powerful engine options, making it a true flagship sedan.
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 798 currently listed for sale and an average price of $62,181.00, 32.0% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.7% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features an updated infotainment system, advanced ride comfort with a new air suspension, and powerful engine options, making it a true flagship sedan.
Why it stands out
The 2021 Mercedes-Benz S-Class stands out as an epitome of luxury and technology, continuing its legacy as a premier choice for those seeking a full-size luxury sedan. It boasts significant upgrades over its predecessor, including a sophisticated infotainment system with enhanced computing power and a sleek digital display, ensuring that all essential functions are intuitively managed. The vehicle offers two powerful engine options, a turbo inline-six producing 429 hp and a V8 with 496 hp, both delivering rapid acceleration without compromising comfort. Additionally, the introduction of rear-wheel steering enhances handling, making it easier to maneuver despite its size. While some owners have raised concerns about the run-flat tires, the overall luxurious feel, advanced technology, and exceptional performance make the S-Class a compelling choice in the luxury market.
Other model years to consider
- Average price: $65,735.00
- Good/great deal percentage: 31.9%
- User rating: 4.5 / 5
- Total listings: 1,124
- Average price: $80,346.00
- Good/great deal percentage: 32.1%
- Total listings: 1,223
- Average price: $21,919.00
- Good/great deal percentage: 33.0%
- User rating: 5 / 5
- Total listings: 817
This analysis is based on CarGurus' proprietary market data from May 25, 2026, CarGurus experts' opinions, and generative AI.
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Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
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