Used 2021 Mercedes-Benz S-Class S 580 Sedan 4MATIC for Sale Nationwide
148 results
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Selenite Grey)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma grey)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 50,415
- Stock #:
- MA060758
- VIN:
- W1K6G7GB0MA060758
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
50,415 mi
Bluffton, SC
Fair Deal
$63,050
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 48,097
- Stock #:
- 056771
- VIN:
- W1K6G7GB5MA056771
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
48,097 mi
Duluth, GA
Great Deal
$55,384
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/ Magma Grey Nappa Leather)
- Transmission:
- Automatic
- Mileage:
- 46,020
- Stock #:
- A040200U
- VIN:
- W1K6G7GB3MA040200
Price drop
-$2,001
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
46,020 mi
Bay Shore, NY
Great Deal
$55,170
$53,169
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Graphite Grey Metallic)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 37,277
- Stock #:
- 9254-TR
- VIN:
- W1K6G7GB9MA043957
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
37,277 mi
Joliet, IL
Fair Deal
$65,353
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 49,125
- Stock #:
- 043991
- VIN:
- W1K6G7GB9MA043991
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
49,125 mi
Largo, FL
Fair Deal
$59,950
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,299
- Stock #:
- U5775
- VIN:
- W1K6G7GB2MA035828
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
35,299 mi
Yuba City, CA
Fair Deal
$63,920
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Nappa
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,943
- Stock #:
- 19482C
- VIN:
- W1K6G7GB9MA041531
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
30,943 mi
Seneca, SC
Fair Deal
$65,499
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 36,133
- Stock #:
- BR25S083A
- VIN:
- W1K6G7GB6MA042278
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
36,133 mi
Rochester, NY
Fair Deal
$64,936
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Red
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 19,741
- Stock #:
- 017428
- VIN:
- W1K6G7GB6MA017428
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
19,741 mi
Snellville, GA
Good Deal
$62,999
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,829
- Stock #:
- M5120A
- VIN:
- W1K6G7GB2MA023937
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
40,829 mi
Little Rock, AR
Fair Deal
$64,829
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 10,575
- Stock #:
- 047434
- VIN:
- W1K6G7GB8MA047434
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
10,575 mi
Madison, NC
Fair Deal
$72,521
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Cirrus Silver
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- Automatic
- Mileage:
- 50,435
- Stock #:
- MA035071
- VIN:
- W1K6G7GB4MA035071
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
50,435 mi
Wesley Chapel, FL
Great Deal
$57,757
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Anthracite Blue Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 28,808
- Stock #:
- Y128481
- VIN:
- W1K6G7GBXMA028481
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
28,808 mi
Washington, PA
Fair Deal
$65,490
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Anthracite Blue
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- Automatic
- Mileage:
- 69,101
- Stock #:
- N23635
- VIN:
- W1K6G7GB4MA016634
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
69,101 mi
Chicago, IL
Fair Deal
$53,319
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Cirrus Silver
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- Automatic
- Mileage:
- 40,647
- Stock #:
- BN1858
- VIN:
- W1K6G7GB6MA033810
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
40,647 mi
Henderson, NV
Fair Deal
$65,489
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Nappa Leather
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,642
- Stock #:
- M260253A
- VIN:
- W1K6G7GB4MA054316
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
44,642 mi
Lake Bluff, IL
Fair Deal
$63,779
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 55,273
- Stock #:
- N23535
- VIN:
- W1K6G7GB6MA056665
Price drop
-$1,500
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
55,273 mi
Chicago, IL
Great Deal
$51,819
$50,319
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Beigen
- Transmission:
- 9-Speed Automatic
- Mileage:
- 33,118
- Stock #:
- MA034911
- VIN:
- W1K6G7GB6MA034911
Price drop
-$2,000
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
33,118 mi
Indianapolis, IN
Good Deal
$65,225
$63,225
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 43,795
- Stock #:
- 039208
- VIN:
- W1K6G7GB3MA039208
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
43,795 mi
Williamstown, NJ
Good Deal
$61,895
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 63,435
- Stock #:
- MA054177P
- VIN:
- W1K6G7GB5MA054177
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
63,435 mi
Killeen, TX
Fair Deal
$55,702
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 56,165
- Stock #:
- PBC100199
- VIN:
- W1K6G7GB0MA034631
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
56,165 mi
Jacksonville, FL
Fair Deal
$60,081
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 70,493
- Stock #:
- P758478LB
- VIN:
- W1K6G7GB2MA020018
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
70,493 mi
Barrington, IL
Fair Deal
$53,312
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 33,180
- Stock #:
- C4777
- VIN:
- W1K6G7GBXMA042736
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
33,180 mi
North Plainfield, NJ
Fair Deal
$64,993
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Selenite Grey)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 18,203
- Stock #:
- MA055645
- VIN:
- W1K6G7GB6MA055645
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
18,203 mi
Hardeeville, SC
Fair Deal
$70,598
Overview
The Mercedes-Benz S-Class S 580 4MATIC Sedan AWD is part of a generation that was introduced for the 2021 model year. This big luxury sedan boasts twin-turbocharged V8 power with a mild-hybrid system, and slots under the ultra-luxury Maybach versions of the S-Class. It’s a great car for those with chauffeurs, since the upscale and comfortable cabin can be upgraded with amenities such as pop-out tables and massaging rear seats with pillows and leg rests. Consider the Audi A7 and Genesis G80 as well if you’re shopping for the Mercedes-Benz S-Class S 580 4MATIC Sedan AWD.
Key Features
- 4.0-liter twin-turbocharged V8 engine
- All-wheel drive
- Sedan body style
- Available Executive Rear Seat package
Pricing Details
The 2023 Mercedes-Benz S-Class S 580 4MATIC Sedan AWD has an MSRP of $124,000. The S-Class was fully redesigned for 2021, which is when this trim was introduced, and had an MSRP of $116,300. Used examples on CarGurus range from $44,995.00 to $89,999.00 with an average price of $61,388.27.
Specifications
Performance
Engine
4.0-liter twin-turbocharged V8 engine
Transmission
Nine-speed automatic transmission
Drivetrain
All-wheel drive
Horsepower/Torque
496 hp/516 lb-ft
0-60 mph
4.0 seconds (estimated)
MPG
18 mpg city, 27 highway, 21 combined
Curb weight
4,762 pounds
Dimensions
wheelbase
126.6 inches
length
208.2 inches
width
76.9 inches
height
59.2 inches
Relevant articles
CarGurus Editorial Team
The Best Sedans of 2026
As more people flock to SUVs and crossovers, some automakers are killing off sedans. But others are doubling down, building some of the best four-door cars we’ve ever driven. For a supposedly dying segment, the sedan market looks awfully healthy.
Chris Teague
Mercedes-Benz S-Class Buying Guide: Cost, Reliability, and the Best Years to Buy
Discover the ultimate buying guide for purchasing a used Mercedes-Benz S-Class, covering every generation since 1951. Whether you're a first-time buyer or a Mercedes enthusiast, this comprehensive overview will help you research your next pre-owned Mercedes-Benz S-Class.
Alex Wagner
2026 Mercedes-Benz S-Class Pricing, Specs, and Release Date
Mercedes-Benz avoids drastic change with the 2026 S-Class sedan and instead refines the lineup with updated packages and configurations, plus a host of new paint colors and interior treatments.
FAQs
How much does the Mercedes-Benz S-Class S 580 Sedan 4MATIC cost?
The average Mercedes-Benz S-Class S 580 Sedan 4MATIC costs about $61,826.21. The average price has decreased by -0.9% since last year. The 148 for sale on CarGurus range from $44,995 to $89,999 in price.
How many Mercedes-Benz S-Class S 580 Sedan 4MATIC vehicles have no reported accidents or damage?
125 out of 148 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz S-Class S 580 Sedan 4MATIC?
Depending on the engine and options, the Mercedes-Benz S-Class S 580 Sedan 4MATIC gets between 20 and 20 MPG (or EV battery range).
What fuel types are available?
Gasoline engines are available.
All Used CarsManual Transmission CarsLuxury CarsCars with Red InteriorCheap Manual CarsHybrid CarsSports CarsElectric SUVsCheap TrucksSmall CarsThird Row SUVsThree Quarter Ton TrucksLifted TrucksManual Transmission TrucksDiesel TrucksHybrid SUVsDually TrucksOne Ton TrucksCheap SUVsLifted Ford Trucks4x4 TrucksWork TrucksAWD SUVsFord TrucksChevrolet TrucksToyota TrucksTrucks Under $10,000Cars Under $15,000Sports Cars Under $20,000Trucks Under $20,000Used Sedans for Sale with Low MileageUsed SUVs / Crossovers for Sale with Low MileageUsed Hatchbacks for Sale with Low MileageUsed Convertibles for Sale with Low MileageUsed Vans for Sale with Low MileageUsed Minivans for Sale with Low MileageUsed Pickup Trucks for Sale with Low MileageUsed Coupes for Sale with Low MileageUsed Wagons for Sale with Low Mileage
