Used 2021 Mercedes-Benz S-Class S 580 Sedan 4MATIC for SaleNationwide
155 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,459
- Stock #:
- HPM017886
- VIN:
- W1K6G7GB3MA017886
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
34,459 mi
West Palm Beach, FL
Good Deal
$60,776
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,102
- Stock #:
- DM231
- VIN:
- W1K6G7GB0MA052711
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
35,102 mi
Denver, CO
Fair Deal
$61,990
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Emerald Green Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Porcelain/Espresso Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 21,462
- Stock #:
- A052961T
- VIN:
- W1K6G7GB1MA052961
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
21,462 mi
Escondido, CA
Great Deal
$65,082
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Nappa Leather
- Transmission:
- 9-Speed Automatic
- Mileage:
- 42,567
- Stock #:
- Q1217
- VIN:
- W1K6G7GB6MA026839
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
42,567 mi
Saint Charles, IL
Fair Deal
$62,904
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Nappa
- Transmission:
- 9-Speed Automatic
- Mileage:
- 26,854
- Stock #:
- E231651
- VIN:
- W1K6G7GB0MA033950
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
26,854 mi
Santa Fe, NM
Good Deal
$65,337
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- designo Diamond White Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Stone Exclusive Leather
- Transmission:
- 9-Speed Automatic
- Mileage:
- 18,814
- Stock #:
- MA036186
- VIN:
- W1K6G7GB4MA036186
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
18,814 mi
St Paul, MN
Good Deal
$68,003
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- SELENITE GRAY METALLIC
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- BLACK NAPPA LEATHER
- Transmission:
- 9-Speed Automatic
- Mileage:
- 16,305
- Stock #:
- 0892
- VIN:
- W1K6G7GB9MA056272
Price drop
-$3,000
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
16,305 mi
San Ramon, CA
Great Deal
$63,075
$60,075
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Anthracite Blue Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Silver Gray/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,156
- Stock #:
- 4206V
- VIN:
- W1K6G7GB0MA042275
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
30,156 mi
Metairie, LA
Fair Deal
$64,498
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Anthracite Blue Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Porcelain/Espresso Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,961
- Stock #:
- M23947
- VIN:
- W1K6G7GB3MA046577
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
31,961 mi
Huntsville, AL
Good Deal
$63,770
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Silver Gray/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,317
- Stock #:
- 025047F01
- VIN:
- W1K6G7GB1MA025047
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
32,317 mi
Ewing, NJ
Good Deal
$60,398
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 25,767
- Stock #:
- P1069
- VIN:
- W1K6G7GB7MA043973
Price drop
-$4,001
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
25,767 mi
Beverly Hills, CA
Good Deal
$67,977
$63,976
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 21,944
- Stock #:
- SX18729
- VIN:
- W1K6G7GB4MA023132
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
21,944 mi
Mount Holly, NJ
Great Deal
$62,494
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Graphite Grey Metallic)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- Automatic
- Mileage:
- 84,154
- Stock #:
- MA024832I
- VIN:
- W1K6G7GB4MA024832
Price drop
-$2,500
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
84,154 mi
Birmingham, AL
Fair Deal
$50,499
$47,999
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Diamond
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,254
- Stock #:
- 09836A
- VIN:
- W1K6G7GB3MA043985
Price drop
-$3,000
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
41,254 mi
Metairie, LA
Great Deal
$57,434
$54,434
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- 9-Speed Automatic
- Mileage:
- 59,906
- Stock #:
- 019534
- VIN:
- W1K6G7GB4MA019534
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
59,906 mi
Houston, TX
Great Deal
$50,144
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- designo Diamond White Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey Exclusive Nappa Leather)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 52,653
- Stock #:
- 5718
- VIN:
- W1K6G7GB6MA040773
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
52,653 mi
Warren, MI
Fair Deal
$58,270
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Nappa
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,093
- Stock #:
- P19333
- VIN:
- W1K6G7GB8MA028608
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
49,093 mi
Tamarac, FL
Good Deal
$56,247
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 38,464
- Stock #:
- ABC998
- VIN:
- W1K6G7GB4MA057541
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
38,464 mi
Scottsdale, AZ
Fair Deal
$62,586
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Graphite Grey)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- Automatic
- Mileage:
- 47,312
- Stock #:
- MA033482
- VIN:
- W1K6G7GB4MA033482
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
47,312 mi
Ft. Lauderdale, FL
Good Deal
$57,485
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,987
- Stock #:
- MA047653
- VIN:
- W1K6G7GB9MA047653
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
58,987 mi
Alpharetta, GA
Fair Deal
$57,497
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 25,360
- Stock #:
- I32635
- VIN:
- W1K6G7GB9MA053548
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
25,360 mi
Columbus, OH
Fair Deal
$66,438
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 20,345
- Stock #:
- A24008A
- VIN:
- W1K6G7GB0MA017408
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
20,345 mi
Bethesda, MD
Fair Deal
$67,680
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 64,948
- Stock #:
- GMA051470
- VIN:
- W1K6G7GBXMA051470
New arrival
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
64,948 mi
Fort Myers, FL
Fair Deal
$53,048
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Nappa Leather
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,674
- Stock #:
- M260253A
- VIN:
- W1K6G7GB4MA054316
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
44,674 mi
Lake Bluff, IL
Fair Deal
$60,141
Overview
The Mercedes-Benz S-Class S 580 4MATIC Sedan AWD is part of a generation that was introduced for the 2021 model year. This big luxury sedan boasts twin-turbocharged V8 power with a mild-hybrid system, and slots under the ultra-luxury Maybach versions of the S-Class. It’s a great car for those with chauffeurs, since the upscale and comfortable cabin can be upgraded with amenities such as pop-out tables and massaging rear seats with pillows and leg rests. Consider the Audi A7 and Genesis G80 as well if you’re shopping for the Mercedes-Benz S-Class S 580 4MATIC Sedan AWD.
Key Features
- 4.0-liter twin-turbocharged V8 engine
- All-wheel drive
- Sedan body style
- Available Executive Rear Seat package
Pricing Details
The 2023 Mercedes-Benz S-Class S 580 4MATIC Sedan AWD has an MSRP of $124,000. The S-Class was fully redesigned for 2021, which is when this trim was introduced, and had an MSRP of $116,300. Used examples on CarGurus range from $44,349.00 to $89,000.00 with an average price of $59,429.80.
Specifications
Performance
Engine
4.0-liter twin-turbocharged V8 engine
Transmission
Nine-speed automatic transmission
Drivetrain
All-wheel drive
Horsepower/Torque
496 hp/516 lb-ft
0-60 mph
4.0 seconds (estimated)
MPG
18 mpg city, 27 highway, 21 combined
Curb weight
4,762 pounds
Dimensions
wheelbase
126.6 inches
length
208.2 inches
width
76.9 inches
height
59.2 inches
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
FAQs
How much does the Mercedes-Benz S-Class S 580 Sedan 4MATIC cost?
The average Mercedes-Benz S-Class S 580 Sedan 4MATIC costs about $59,892.40. The average price has decreased by -1.2% since last year. The 155 for sale on CarGurus range from $44,349 to $89,000 in price.
How many Mercedes-Benz S-Class S 580 Sedan 4MATIC vehicles have no reported accidents or damage?
120 out of 155 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz S-Class S 580 Sedan 4MATIC?
Depending on the engine and options, the Mercedes-Benz S-Class S 580 Sedan 4MATIC gets between 20 and 20 MPG (or EV battery range).
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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