Used 2021 Mercedes-Benz S-Class for Sale nearLos Angeles, CA
166 vehicles found
See the total price upfront.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 57,689
- Stock #:
- 26092
- VIN:
- W1K6G6DBXNA098627
Sponsored by Major Motor Cars
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
57,689 mi
$49,554
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Manufaktur Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 54,876
- Stock #:
- 26305
- VIN:
- W1K6G6DB8NA166553
Sponsored Listing
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
54,876 mi
$48,897
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,108
- Stock #:
- 8XF06600
- VIN:
- W1K6G7GBXNA139727
Sponsored Listing
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
44,108 mi
$63,555
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 43,861
- Stock #:
- 8995B
- VIN:
- W1K6G7GB3MA043792
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
43,861 mi
$61,888
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Tan)
- Transmission:
- Automatic
- Mileage:
- 22,154
- Stock #:
- PNA078679
- VIN:
- W1K6G6DB6NA078679
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
22,154 mi
$60,081
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- designo Diamond White Metallic
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silk Beige/Espresso Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 51,174
- Stock #:
- TV27304
- VIN:
- WDDUG8DBXLA523022
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
51,174 mi
$41,622
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Blue
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 48,212
- Stock #:
- 226333
- VIN:
- W1KUG8DB5LA560012
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
48,212 mi
$41,084
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 30,361
- Stock #:
- 226460
- VIN:
- W1K6G6DB6NA125497
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
30,361 mi
$53,973
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Magma Grey/Espresso Brown)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 63,670
- Stock #:
- LA557756P
- VIN:
- W1KUG8DB5LA557756
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
63,670 mi
$39,167
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (TAN)
- Transmission:
- Automatic
- Mileage:
- 84,732
- Stock #:
- LA559618
- VIN:
- W1KUG8DB3LA559618
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
84,732 mi
$32,985
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray (Graphite Grey)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 18,821
- Stock #:
- NA166316
- VIN:
- W1K6G6DB5NA166316
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
18,821 mi
$56,668
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,936
- Stock #:
- CGSP16604
- VIN:
- W1K6G7GB3NA166672
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
31,936 mi
$65,080
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- Automatic
- Mileage:
- 39,377
- Stock #:
- 073511
- VIN:
- W1K6G7GB7NA073511
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
39,377 mi
$65,716
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 168 currently listed for sale near Los Angeles, CA and an average price of $69,227.00, 25.0% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
89.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system, advanced safety features, and a choice of powerful engines, including a turbocharged inline-six and a twin-turbo V8.
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,108
- Stock #:
- 8XF06600
- VIN:
- W1K6G7GBXNA139727
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
44,108 mi
$63,555
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 62,754
- Stock #:
- PX2678
- VIN:
- W1K6G7GB6MA045794
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
62,754 mi
$55,636
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 63,212
- Stock #:
- 26308
- VIN:
- W1K6G6DB7NA105484
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
63,212 mi
$48,550
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Nappa
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,722
- Stock #:
- TC4186
- VIN:
- W1K6G7GB4NA129372
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,722 mi
$68,122
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,848
- Stock #:
- 3P2859
- VIN:
- W1K6G6DB1NA142417
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
32,848 mi
$59,077
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Manufaktur Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 54,876
- Stock #:
- 26305
- VIN:
- W1K6G6DB8NA166553
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
54,876 mi
$48,897
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 51,216
- Stock #:
- L12139
- VIN:
- WDDUG8DB0LA516936
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
51,216 mi
$40,084
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- designo Diamond White Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 48,299
- Stock #:
- MA023377
- VIN:
- W1K6G7GB1MA023377
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
48,299 mi
$59,377
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 603 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 77,795
- Stock #:
- 12435
- VIN:
- W1KUG8JB0LA555143
2020 Mercedes-Benz S-Class
S AMG 63 4MATIC Sedan AWD
77,795 mi
$63,888
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 30,361
- Stock #:
- 226460
- VIN:
- W1K6G6DB6NA125497
Sponsored Listing
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
30,361 mi
$53,973
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 168 currently listed for sale near Los Angeles, CA and an average price of $69,227.00, 25.0% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
89.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system, advanced safety features, and a choice of powerful engines, including a turbocharged inline-six and a twin-turbo V8.
Why it stands out
The 2021 Mercedes-Benz S-Class continues to uphold its reputation as a flagship luxury sedan, offering a blend of performance, comfort, and cutting-edge technology. With a redesigned exterior that boasts a drag coefficient of just 0.22, the S-Class not only looks elegant but also enhances fuel efficiency. Inside, the cabin is a showcase of luxury, featuring high-quality materials, ambient lighting with 64 color options, and a state-of-the-art infotainment system that includes a 12.8-inch OLED touchscreen. The S-Class is available in two configurations: the S500 with a 3.0-liter inline-six engine and the S580 with a 4.0-liter twin-turbo V8, both equipped with a mild-hybrid system for improved efficiency. The driving experience is further enhanced by standard air suspension and rear-wheel steering, making it agile for a full-size sedan. While the price point is high, the S-Class offers features and performance that justify the investment, making it a compelling choice for luxury car buyers.
Other model years to consider
- Average price: $73,509.00
- Good/great deal percentage: 23.4%
- Total listings: 295
- Average price: $65,839.00
- Good/great deal percentage: 24.3%
- User rating: 4.5 / 5
- Total listings: 259
- Average price: $27,455.00
- Good/great deal percentage: 21.9%
- User rating: 4.95 / 5
- Total listings: 187
This analysis is based on CarGurus' proprietary market data from July 1, 2026, CarGurus experts' opinions, and generative AI.
4.0 Overall rating
Filter by rating
Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
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