Used 2021 Mercedes-Benz S-Class for Sale nearLancaster, CA
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,848
- Stock #:
- 3P2859
- VIN:
- W1K6G6DB1NA142417
Sponsored by Mercedes-Benz of Encino
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
32,848 mi
$56,577
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 37,769
- Stock #:
- 11721
- VIN:
- W1K6G6DB9NA166593
Sponsored Listing
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
37,769 mi
$58,118
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 621 hp 6L V12
- Exterior color:
- Black
- Combined gas mileage:
- 17 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 7-Speed Automatic
- Mileage:
- 57,106
- Stock #:
- 530774
- VIN:
- W1KUX8AB9LA530774
Sponsored Listing
2020 Mercedes-Benz S-Class
Maybach S 650 Sedan RWD
57,106 mi
$69,999
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Selenite Gray Magno
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 43,177
- Stock #:
- 3P2901
- VIN:
- W1K6G7GB6NA141751
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
43,177 mi
$62,577
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 22,653
- Stock #:
- P1056
- VIN:
- W1K6G7GB9NA135457
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
22,653 mi
$67,978
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,848
- Stock #:
- 3P2859
- VIN:
- W1K6G6DB1NA142417
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
32,848 mi
$56,577
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,886
- Stock #:
- 3P2944
- VIN:
- W1K6G7GB8NA156946
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
31,886 mi
$64,177
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 51,216
- Stock #:
- L12139
- VIN:
- WDDUG8DB0LA516936
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
51,216 mi
$39,391
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- Automatic
- Mileage:
- 37,981
- Stock #:
- 10414
- VIN:
- W1K6G6DB3NA166640
-$1,500
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
37,981 mi
$57,895
$56,395
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 67,452
- Stock #:
- 12650
- VIN:
- W1KUG8DB8LA528168
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
67,452 mi
$38,082
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 603 hp 4L V8
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,263
- Stock #:
- R558983
- VIN:
- W1KUG8JB4LA558983
2020 Mercedes-Benz S-Class
S AMG 63 4MATIC Sedan AWD
41,263 mi
$79,300
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Gray (Selenite Grey M)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 42,809
- Stock #:
- 522209H
- VIN:
- WDDUG8GB5LA522209
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
42,809 mi
$43,229
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 10,579
- Stock #:
- 3P3011
- VIN:
- W1K6G6DB3NA147764
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
10,579 mi
$66,577
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 694 currently listed for sale and an average price of $61,302.00, 29.1% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
83.6% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system, advanced safety features, and powerful engine options, including a turbocharged inline-six and a twin-turbo V8.
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Cashmere White Magno
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 22,565
- Stock #:
- D4017S
- VIN:
- W1K6G6DB4NA078714
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
22,565 mi
$59,970
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 71,885
- Stock #:
- 26020
- VIN:
- W1K6G7GB6NA077355
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
71,885 mi
$50,665
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- Magnetite Black Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 44,628
- Stock #:
- 11108
- VIN:
- WDDUG6EBXLA514744
2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
44,628 mi
$37,795
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 603 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 77,795
- Stock #:
- 12435
- VIN:
- W1KUG8JB0LA555143
2020 Mercedes-Benz S-Class
S AMG 63 4MATIC Sedan AWD
77,795 mi
$60,082
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Manufaktur Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 54,876
- Stock #:
- 26305
- VIN:
- W1K6G6DB8NA166553
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
54,876 mi
$48,897
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diam
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 25,965
- Stock #:
- 152088MM
- VIN:
- W1K6G7GB1NA152088
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
25,965 mi
$73,029
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,354
- Stock #:
- T3098
- VIN:
- W1K6G7GB0NA159825
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
31,354 mi
$65,973
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Cashmere White Magno
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,742
- Stock #:
- NA158007
- VIN:
- W1K6G6DB7NA158007
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
45,742 mi
$55,506
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,587
- Stock #:
- 067274
- VIN:
- W1K6G6DB2NA067274
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
32,587 mi
$56,054
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 41,088
- Stock #:
- LNA107931
- VIN:
- W1K6G7GB3NA107931
Sponsored Listing
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
41,088 mi
$63,084
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 694 currently listed for sale and an average price of $61,302.00, 29.1% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
83.6% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system, advanced safety features, and powerful engine options, including a turbocharged inline-six and a twin-turbo V8.
Why it stands out
The 2021 Mercedes-Benz S-Class continues to uphold its reputation as a flagship luxury sedan, offering a blend of performance, comfort, and cutting-edge technology. With a redesigned exterior that enhances aerodynamics and a spacious interior filled with high-quality materials, the S-Class is designed for those who appreciate the finer things in life. The introduction of the EQ Boost mild-hybrid system in both the S500 and S580 models not only improves efficiency but also enhances performance, allowing for impressive acceleration times of 4.8 seconds and 4.4 seconds, respectively. The advanced infotainment system, featuring a 12.8-inch OLED touchscreen and a 12.3-inch digital instrument cluster, provides a user-friendly interface with wireless Apple CarPlay and Android Auto. Additionally, the S-Class is equipped with a comprehensive suite of safety features, including adaptive cruise control and automated lane centering, ensuring a secure driving experience. While the price point may be high, the S-Class offers unmatched luxury and technology, making it a compelling choice for buyers in the luxury sedan market.
Other model years to consider
- Average price: $78,500.00
- Good/great deal percentage: 29.6%
- Accident-free percentage: 90.7%
- Total listings: 1,221
- Average price: $63,420.00
- Good/great deal percentage: 29.5%
- User rating: 4.5 / 5
- Total listings: 1,097
- Average price: $25,482.00
- Good/great deal percentage: 31.2%
- User rating: 4.95 / 5
- Total listings: 913
This analysis is based on CarGurus' proprietary market data from July 31, 2026, CarGurus experts' opinions, and generative AI.
4.0 Overall rating
Filter by rating
Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
See more price trendsFAQs
How much does the 2021 Mercedes-Benz S-Class cost in Lancaster, CA?
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