Used 2021 Mercedes-Benz S-Class for Sale near Houston, TX

## Summary - With 812 currently listed for sale on CarGurus and an **average price of $61,300.00**, 29.8% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals. - **Favorably reviewed:** Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars. - **83.6% of 2021 S-Class models on CarGurus are accident free**. - The 2021 Mercedes-Benz S-Class launched with a sophisticated infotainment system, advanced powertrains, and improved aerodynamic bodywork, ensuring it remains at the forefront of luxury sedans. ## Why it stands out The 2021 Mercedes-Benz S-Class distinguishes itself in the competitive luxury sedan market with significant updates that solidify its reputation as a technological and performance leader. This model year introduces both the S500 and S580 configurations, each boasting robust engine options, including a mild-hybrid system that enhances efficiency and power. The S-Class' interior reflects a commitment to unmatched comfort and advanced technology, featuring a minimalist design that emphasizes a large touchscreen interface and extensive ambient lighting options. While the S-Class excels in many areas, such as its powerful engine options and luxurious appointments, some owners have mentioned issues with the run-flat tires, indicating not all aspects are flawless. Nonetheless, the car remains a benchmark for comfort and performance in the full-size luxury segment. ## Other model years to consider - **[2022 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2022-Mercedes-Benz-S-Class-c31858)** - Average price: $66,674.00 - Good/great deal percentage: 29.1% - User rating: 4.8 / 5 - Total listings: 1,043 - **[2015 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2015-Mercedes-Benz-S-Class-c24430)** - Average price: $25,868.00 - Good/great deal percentage: 28.9% - User rating: 4.88 / 5 - Total listings: 893 - **[2019 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2019-Mercedes-Benz-S-Class-c28135)** - Average price: $40,967.00 - Good/great deal percentage: 31.4% - User rating: 4.85 / 5 - Total listings: 733 This analysis is based on CarGurus' proprietary market data from February 9, 2026, CarGurus experts' opinions, and generative AI.