Used 2021 Mercedes-Benz S-Class for Sale near Philadelphia, PA
176 results
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 184 currently listed for sale near Philadelphia, PA and an average price of $63,347.00, 26.1% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.2% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class showcases advanced technology and offers two powerful engine configurations, making it a leader in the luxury sedan segment.
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall

Summary
With 184 currently listed for sale near Philadelphia, PA and an average price of $63,347.00, 26.1% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.2% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class showcases advanced technology and offers two powerful engine configurations, making it a leader in the luxury sedan segment.
Why it stands out
The 2021 Mercedes-Benz S-Class continues to solidify its standing as the flagship of the Mercedes lineup by delivering a premium blend of luxury, performance, and innovative technology. With a redesign that enhances both aesthetics and functionality, the S-Class now features a more sophisticated infotainment system and improved powertrains, including a powerful V8 engine option. Owners have expressed great satisfaction with its luxurious feel, advanced driver assistance features, and impressive performance, particularly highlighting the exhilarating handling and acceleration. While some have reported issues with the run-flat tires, the overall experience remains overwhelmingly positive.
The car's spacious interior, equipped with high-quality materials, ensures comfort for all passengers, while the advanced technology offers connectivity options that are at the forefront of the luxury segment. The introduction of unique features like augmented-reality navigation further distinguishes the S-Class from its competition. Ultimately, this model is not just about opulence; it provides an exhilarating driving experience, making it an appealing choice for those seeking both comfort and performance in a luxury vehicle.
Other model years to consider
- Average price: $75,386.00
- Good/great deal percentage: 23.4%
- Total listings: 274
- Average price: $67,786.00
- Good/great deal percentage: 25.6%
- User rating: 4.5 / 5
- Total listings: 262
- Average price: $27,326.00
- Good/great deal percentage: 25.3%
- User rating: 5 / 5
- Total listings: 257
This analysis is based on CarGurus' proprietary market data from April 21, 2026, CarGurus experts' opinions, and generative AI.
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Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
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