Used 2021 Mercedes-Benz S-Class for Sale nearLancaster, PA
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Onyx Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 55,671
- Stock #:
- PST1922
- VIN:
- W1K6G7GB3NA073053
Sponsored by Farrish Subaru
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
55,671 mi
$63,994
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 38,859
- Stock #:
- KMBPNA150830
- VIN:
- W1K6G7GB3NA150830
Sponsored Listing
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
38,859 mi
$69,000
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 65,776
- Stock #:
- MB261080A
- VIN:
- W1K6G6DB4NA080835
Sponsored Listing
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
65,776 mi
$50,680
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Selenite Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Nut Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 24,995
- Stock #:
- D261002A
- VIN:
- W1KUG8GB0LA553285
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
24,995 mi
$50,343
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Macchiato/Magma gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,028
- Stock #:
- SX18663
- VIN:
- W1K6G7GB3MA023302
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
45,028 mi
$60,295
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Buckskin Nappa
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,599
- Stock #:
- EP0213
- VIN:
- WDDUG8GB5LA501375
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
49,599 mi
$41,892
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- Lunar Blue Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silk Beige/Espresso Brown
- Transmission:
- Automatic
- Mileage:
- 47,611
- Stock #:
- P6583
- VIN:
- WDDUG6EB5LA511167
2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
47,611 mi
$33,999
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 65,776
- Stock #:
- MB261080A
- VIN:
- W1K6G6DB4NA080835
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
65,776 mi
$50,680
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,842
- Stock #:
- GAL16048A
- VIN:
- W1K6G7GB5NA149081
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
25,842 mi
$73,698
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 76,081
- VIN:
- W1K6G7GB3NA070573
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
76,081 mi
$49,915
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black - 040
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black - 201
- Transmission:
- Automatic
- Mileage:
- 68,934
- Stock #:
- PT7097
- VIN:
- W1K6G7GBXNA096037
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
68,934 mi
$59,790
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- 9-Speed Automatic
- Mileage:
- 104,617
- Stock #:
- 569763
- VIN:
- W1KUG8DB7LA569763
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
104,617 mi
$28,570
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Graphite Grey)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- Automatic
- Mileage:
- 39,376
- Stock #:
- P6682
- VIN:
- W1K6G7GB1MA036369
-$1,500
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
39,376 mi
$60,999
$59,499
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 718 currently listed for sale and an average price of $116,850.00, 30.6% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
83.8% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a redesigned infotainment system, advanced safety technologies, and powerful engine options, including a 4.0-liter twin-turbo V8 in the S580 variant.
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 25,932
- Stock #:
- M-157967
- VIN:
- W1K6G7GBXNA157967
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
25,932 mi
$64,172
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 73,660
- Stock #:
- 10473
- VIN:
- WDDUG8GB9LA497380
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
73,660 mi
$35,289
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- Magnetite Black Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 44,628
- Stock #:
- 11108
- VIN:
- WDDUG6EBXLA514744
2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
44,628 mi
$37,028
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Obsidian Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 53,112
- Stock #:
- K142048
- VIN:
- W1K6G6DB7NA142048
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
53,112 mi
$54,126
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma grey)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 20,197
- Stock #:
- NA140536R
- VIN:
- W1K6G7GB8NA140536
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
20,197 mi
$73,399
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 30,228
- Stock #:
- STK161052
- VIN:
- W1K6G7GB3NA161052
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
30,228 mi
$60,403
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 29,866
- Stock #:
- P3463
- VIN:
- W1K6G6DB2NA143513
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
29,866 mi
$63,787
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,826
- Stock #:
- BA156735
- VIN:
- W1K6G6DB8NA156735
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
45,826 mi
$58,990
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Brown (Beige)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- 9-Speed Automatic
- Mileage:
- 61,249
- Stock #:
- 502088
- VIN:
- WDDUG8DB1LA502088
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
61,249 mi
$38,965
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 27,964
- Stock #:
- 099154
- VIN:
- W1K6G7GB7NA099154
Sponsored Listing
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
27,964 mi
$68,599
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 718 currently listed for sale and an average price of $116,850.00, 30.6% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
83.8% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a redesigned infotainment system, advanced safety technologies, and powerful engine options, including a 4.0-liter twin-turbo V8 in the S580 variant.
Why it stands out
The 2021 Mercedes-Benz S-Class continues to uphold its reputation as a flagship luxury sedan, offering a blend of performance, comfort, and cutting-edge technology. With a choice between the S500 and S580 models, buyers can enjoy powerful engine options, including a 3.0-liter inline-six and a 4.0-liter twin-turbo V8, both equipped with a mild-hybrid system for enhanced efficiency. The S-Class is not just about power; it also boasts a sophisticated air suspension system and rear-wheel steering, which contribute to a smooth and agile driving experience.
Inside, the S-Class impresses with its luxurious materials and advanced infotainment setup, featuring a 12.8-inch OLED touchscreen and a 12.3-inch digital instrument cluster. The cabin is designed for comfort, with power-adjustable seats that offer heating, ventilation, and massage functions. While the S-Class excels in many areas, some users have noted issues with the run-flat tires, indicating that even this luxury vehicle has room for improvement. Overall, the 2021 S-Class remains a top choice for those seeking a high-end sedan that combines performance with luxury.
Other model years to consider
- Average price: $116,850.00
- Good/great deal percentage: 33.0%
- Total listings: 1,235
- Average price: $115,000.00
- Good/great deal percentage: 31.6%
- User rating: 4.5 / 5
- Total listings: 1,124
- Average price: $56,000.00
- Good/great deal percentage: 31.4%
- User rating: 4.95 / 5
- Total listings: 917
This analysis is based on CarGurus' proprietary market data from July 27, 2026, CarGurus experts' opinions, and generative AI.
4.0 Overall rating
Filter by rating
Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
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