Used 2021 Mercedes-Benz S-Class for Sale near Florida
164 results
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 33,377
- Stock #:
- NA143935
- VIN:
- W1K6G6DB6NA143935
Sponsored by Mercedes-Benz Pompano
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
33,377 mi
$61,491
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 42,210
- Stock #:
- 059775
- VIN:
- W1K6G7GB6MA059775
Sponsored Listing
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
42,210 mi
$64,989
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,450
- Stock #:
- 019947
- VIN:
- W1K6G7GB7MA019947
Sponsored Listing
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
49,450 mi
$57,996
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,564
- Stock #:
- HP00631
- VIN:
- W1K6G6DB5NA102809
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
36,564 mi
$56,239
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Blue
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sand
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,984
- Stock #:
- R533161
- VIN:
- W1KUG8DB8LA533161
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
31,984 mi
$44,780
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 33,628
- Stock #:
- A158768
- VIN:
- W1K6G6DB0NA158768
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
33,628 mi
$56,048
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 33,377
- Stock #:
- NA143935
- VIN:
- W1K6G6DB6NA143935
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
33,377 mi
$61,491
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Cashmere White Magno
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 39,500
- Stock #:
- 30205
- VIN:
- W1K6G7GB8NA112851
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
39,500 mi
$71,349
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,029
- Stock #:
- 143767
- VIN:
- W1K6G7GB9NA143767
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
25,029 mi
$74,950
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,450
- Stock #:
- 019947
- VIN:
- W1K6G7GB7MA019947
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
49,450 mi
$57,996
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 27,075
- Stock #:
- P150761
- VIN:
- W1K6G6DB1NA150761
-$3,791
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
27,075 mi
$66,704
$62,913
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 621 hp 6L V12
- Exterior color:
- Black
- Combined gas mileage:
- 17 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 43,078
- Stock #:
- 8G47341A
- VIN:
- W1KUX8ABXLA563797
2020 Mercedes-Benz S-Class
Maybach S 650 Sedan RWD
43,078 mi
$82,083
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Red
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 19,741
- Stock #:
- 017428
- VIN:
- W1K6G7GB6MA017428
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
19,741 mi
$64,898
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 753 currently listed for sale and an average price of $61,807.00, 33.1% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.5% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class introduces advanced technology features, impressive powertrains, and luxurious interior fittings, along with a sophisticated infotainment system.
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 27,075
- Stock #:
- L5056
- VIN:
- WDDUG8GB4LA502792
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
27,075 mi
$52,739
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 50,618
- Stock #:
- 513856
- VIN:
- WDDUG8DB9LA513856
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
50,618 mi
$42,297
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Porcelain/Espresso)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 13,722
- Stock #:
- P109013
- VIN:
- W1K6G7GB8NA109013
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
13,722 mi
$75,592
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 51,658
- Stock #:
- 145332
- VIN:
- W1K6G7GB6NA145332
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
51,658 mi
$64,689
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 33,958
- Stock #:
- 44037
- VIN:
- W1K6G6DB9NA163712
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
33,958 mi
$59,379
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- Automatic
- Mileage:
- 54,238
- Stock #:
- 70031190
- VIN:
- W1K6G7GB8NA150225
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
54,238 mi
$62,997
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 28,759
- Stock #:
- 2GW200404
- VIN:
- W1K6G7GB7NA086176
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
28,759 mi
$61,350
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,669
- Stock #:
- P041898
- VIN:
- W1KXJ8GB6LA041898
2020 Mercedes-Benz S-Class
S 560 4MATIC Coupe AWD
23,669 mi
$69,760
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Magnetite Black Metallic
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Porcelain/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 39,527
- Stock #:
- 515696
- VIN:
- WDDUG8DB1LA515696
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
39,527 mi
$44,796
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 27,075
- Stock #:
- L5056
- VIN:
- WDDUG8GB4LA502792
Sponsored Listing
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
27,075 mi
$52,739
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 753 currently listed for sale and an average price of $61,807.00, 33.1% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.5% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class introduces advanced technology features, impressive powertrains, and luxurious interior fittings, along with a sophisticated infotainment system.
Why it stands out
The 2021 Mercedes-Benz S-Class is a pinnacle of luxury and innovation, seamlessly blending performance with sophistication. The introduction of the S-Class features two robust powertrains: the S500 with a turbocharged inline-six engine producing 429 horsepower and the more powerful S580 equipped with a twin-turbo V8 generating 496 horsepower. Both variants showcase the latest in Mercedes' engineering finesse with their agile handling and impressive acceleration. With a newly designed cabin that incorporates a minimalist aesthetic complemented by advanced technology—such as a 12.3-inch digital instrument cluster and a 12.8-inch OLED touchscreen—the S-Class sets a standard for luxury vehicles. Owners appreciate its lavish materials and state-of-the-art features, although some express concerns over the performance of the run-flat tires. The car's commitment to safety is evident through a suite of driver-assist technologies, including adaptive cruise control and lane-keeping assist, enhancing the overall driving experience while maintaining the prestige that is synonymous with the Mercedes brand.
Other model years to consider
- Average price: $78,989.00
- Good/great deal percentage: 34.0%
- Total listings: 1,240
- Average price: $64,892.00
- Good/great deal percentage: 33.9%
- User rating: 4.5 / 5
- Total listings: 1,143
- Average price: $25,826.00
- Good/great deal percentage: 30.4%
- User rating: 4.95 / 5
- Total listings: 951
This analysis is based on CarGurus' proprietary market data from June 22, 2026, CarGurus experts' opinions, and generative AI.
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4.0 Overall rating
Filter by rating
Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
See more price trends
