Used 2021 Lexus IS for Sale nearSan Francisco, CA

How much does the 2021 Lexus IS cost?

Prices are up 2.59% year-over-year — a sign of continued demand for this model year.

There are 537 listings available, which gives you a modest amount of inventory to compare before you buy.

If you find a listing below $33,095.87, that's toward the low end of the year-round range and worth acting on quickly.

Is the 2021 Lexus IS a good car?

Yes — the 2021 Lexus IS earns a 4.62/5 user rating, and its expert rating is 7.33/10. The model scores 8/10 across Look and feel and Cost effectiveness.

Owners consistently praise the stylish design, sporty feel, and luxurious character. They also call out the handling and value for money, which fits a car that aims to feel more expressive than a typical compact luxury sedan.

The trade-offs are familiar: the base engine is underwhelming, the transmission can be irritating, and the tech can feel outdated. That matters most if you want a daily driver that prioritizes easy comfort and the latest features over personality.

For you, the appeal is strongest if you want a premium sedan with a sporty edge rather than a purely comfort-first commuter. The market still shows 33.5% good or great deals, so there are still some attractive opportunities if you shop carefully.

Is the 2021 Lexus IS reliable?

Owners rate it 4.62/5, a strong signal of long-term satisfaction.

The owner feedback points to a car that feels dependable, with many drivers emphasizing the car’s long-term appeal, luxurious character, and overall confidence in ownership. Lexus also leans on its reputation for quality and reliability, which reinforces that message.

On the expert side, the car’s engineering focus on linear, faithful response and its crisp, balanced chassis tuning support the sense that it should be easy to live with over time. Lexus also includes a 10-year complimentary service-connect subscription, which can help you stay on top of maintenance reminders.

For used buyers, the main long-term risk is less about outright durability and more about whether the specific car has been maintained well and whether you can live with its older-feeling tech.

What should I look for when buying a used 2021 Lexus IS?

At 72.6% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.

You should start with a vehicle history report and then prioritize a pre-purchase inspection, especially if the car has had bodywork or multiple owners. Focus on condition, maintenance records, and whether the car’s electronics and driver-assistance features work as intended.

Key things to evaluate:

• Trim level: The lineup includes rear-wheel-drive and all-wheel-drive versions, and the F Sport models add a more aggressive setup and sportier character. The base versions are the ones most likely to leave you wanting more if you care about the full luxury-sport experience.
• Powertrain: You can choose between a 2.0-liter turbo four-cylinder in the rear-wheel-drive IS 300, a naturally aspirated 3.5-liter V6 in the all-wheel-drive IS 300, and a higher-output 3.5-liter V6 in the IS 350. Fuel economy ranges from 21 mpg city, 31 mpg highway, 25 mpg combined in the IS 300 RWD to 19/26/22 in the IS 300 AWD and IS 350 AWD.
• Safety package: Lexus Safety System+ 2.5 is standard, with pre-collision braking and pedestrian detection, lane-departure warning with steering assist, road-sign recognition, lane-tracing assist, full-speed adaptive cruise control, and intelligent high beams. It also includes blind-spot monitoring, rear cross-traffic alert, and a backup camera with dynamic gridlines.
• Infotainment: The touchscreen infotainment system supports both Android Auto and Apple CarPlay. Lexus also includes connected services, with wireless app integration and trial subscriptions for several features.
• Fuel efficiency: The EPA estimates 21 mpg city, 31 mpg highway, 25 mpg combined for the IS 300 RWD, 19/26/22 for the IS 300 AWD, 20/28/23 for the IS 350 RWD, and 19/26/22 for the IS 350 AWD.

Which 2021 Lexus IS trim should I buy?

The 2021 Lexus IS is offered in 4 trim levels: IS 300 RWD, IS 300 AWD, IS 350 RWD F Sport, IS 350 AWD F Sport.

Here's the short version:

• IS 300 RWD: This is the least expensive way into the lineup, and it gives you the rear-wheel-drive setup with the turbocharged four-cylinder. It makes the most sense if you want the lowest entry price and still care about the car’s sporty personality.
• IS 300 AWD: Choose this if you want the V6 and all-weather traction without stepping up to the F Sport models. It adds power over the RWD base trim, but it is also pricier and less efficient.
• IS 350 RWD F Sport: This is the best-value choice if you want the strongest blend of performance and equipment. It brings the higher-output V6 and the F Sport treatment, which better matches the car’s enthusiast mission.
• IS 350 AWD F Sport: Pick this if you want the top non-hybrid gas model with all-wheel drive and the most performance-oriented setup in the lineup. It is the most expensive trim, so it suits you best if you want the fullest expression of the IS without compromise.

Lexus Safety System+ 2.5 is standard across the lineup, so you do not need to move up trims to get the core driver-assistance suite.

Is now a good time to buy a used 2021 Lexus IS?

This looks like a moderate, selective buyer’s market, so you should shop with patience and compare listings carefully.

• Deal availability: 33.5% of listings are priced as good or great deals.
• Inventory: There are 537 listings available.
• Price trend: Prices are up 2.59% year-over-year.
• Clean inventory: 72.6% of listings are accident-free.

If you find a listing below $33,095.87, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Lexus IS's resale value?

The current average of $34,916 sits slightly above last year's $34,035.

That upward move suggests the market has been willing to pay a bit more for this model year, which is a positive sign if you plan to sell later. It also tells you that well-kept examples may hold their appeal better than you might expect in a competitive luxury-sedan segment.

For you, the key resale takeaway is that condition and history will matter a lot. A clean, well-maintained car should be easier to move than one with accident history or neglected maintenance.

Vehicles with strong owner satisfaction ratings, like this model year's 4.62/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Lexus IS safe?

It earns a 7/10 safety score from our experts.

Lexus Safety System+ 2.5 is standard, and it includes a pre-collision system with pedestrian detection, low-light pedestrian detection, daytime bicyclist detection, and left-turn intersection support. It also brings lane-departure warning with steering assist, road-sign recognition, enhanced lane-tracing assist, full-speed dynamic adaptive cruise control, intelligent high beams, blind-spot monitoring with rear cross-traffic alert, a backup camera with dynamic gridlines, and Lexus Enform Safety Connect.

The main caveat is that this model year had not yet been rated for crashworthiness by IIHS or NHTSA at the time of the data. That means you should lean more heavily on the standard safety equipment and the condition of the specific car you’re considering.

Should I buy a 2021 Lexus IS or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 33.5% of listings are priced as good or great deals.
• At 72.6% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.
• Price trend: Prices are up 2.59% year-over-year.
• Owners rate it 4.62/5 — a strong satisfaction signal.
• The 2021 model year brings a major redesign with sharper handling, updated tech, and standard advanced safety features.

Consider the 2022 if:

• At $37,988, the 2022 costs more than the current year's $34,916 average.
• It adds the IS 500 F Sport Performance with a 5.0-liter V8.

The bottom line: If you want the best balance of price, style, and updated features, the 2021 is the smarter buy. If you are willing to spend more for a bigger performance leap, the 2022 is the better path for enthusiast buyers.

These recommendations are based on CarGurus' proprietary market data from September 4, 2026, CarGurus experts' opinions, and generative AI.