Used 2022 Lexus IS for Sale Nationwide
1,011 results
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White W/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 63,161
- Stock #:
- 044240
- VIN:
- JTHGZ1B27M5044240
2021 Lexus IS
350 F Sport RWD
63,161 mi
$36,694
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Cloudburst Gray
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 16,130
- Stock #:
- 066518
- VIN:
- JTHGZ1B29P5066518
2023 Lexus IS
350 F SPORT RWD
16,130 mi
$42,139
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 73,082
- Stock #:
- 057361
- VIN:
- JTHGZ1B25N5057361
2022 Lexus IS
350 F Sport RWD
73,082 mi
$34,473
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Red
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 25,706
- Stock #:
- S020789A
- VIN:
- JTHGZ1B23M5043599
2021 Lexus IS
350 F Sport RWD
25,706 mi
$39,486
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- 8-Speed Automatic
- Mileage:
- 56,338
- Stock #:
- C7382
- VIN:
- JTHGZ1B22N5054272
2022 Lexus IS
350 F Sport RWD
56,338 mi
$36,943
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Cloudburst Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White w Black
- Transmission:
- Automatic
- Mileage:
- 38,555
- Stock #:
- TM256011A
- VIN:
- JTHGZ1E27M5020693
2021 Lexus IS
350 F Sport AWD
38,555 mi
$38,494
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black w/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 49,353
- Stock #:
- P052005
- VIN:
- JTHGZ1B22N5052005
2022 Lexus IS
350 F Sport RWD
49,353 mi
$39,900
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Fuel type:
- Gasoline
- Transmission:
- 8-Speed Dual Clutch
- Mileage:
- 93,794
- Stock #:
- 112797
- VIN:
- JTHCA1D29M5112797
2021 Lexus IS
300 RWD
93,794 mi
$25,999
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- Automatic
- Mileage:
- 87,040
- Stock #:
- 116731
- VIN:
- JTHAA1D20M5116731
2021 Lexus IS
300 RWD
87,040 mi
$27,065
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 24,701
- Stock #:
- PP5061859
- VIN:
- JTHGZ1B2XP5061859
2023 Lexus IS
350 F SPORT RWD
24,701 mi
$43,722
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 50,152
- Stock #:
- MG600122
- VIN:
- JTHGZ1E21P5028213
2023 Lexus IS
350 F SPORT AWD
50,152 mi
$43,049
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultrasonic Blue Mica 2.0
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black W/Ginsumi
- Transmission:
- 8-Speed Automatic
- Mileage:
- 107,868
- Stock #:
- 63846A
- VIN:
- JTHGZ1B27M5037661
2021 Lexus IS
350 F Sport RWD
107,868 mi
$29,225
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Cloudburst Gray
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red W/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 54,643
- Stock #:
- 329806A
- VIN:
- JTHGZ1B20N5058157
2022 Lexus IS
350 F Sport RWD
54,643 mi
$40,164
CarGurus Analysis:
2022 Lexus IS
With 983 currently listed for sale and an average price of $38,352.00, 33.9% of 2022 Lexus IS cars for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Lexus IS 5 / 5 stars.
82.5% of 2022 Lexus IS models on CarGurus are accident-free.
The 2022 Lexus IS combines a luxurious feel with a quiet ride and powerful V6 engine performance, appealing to driving enthusiasts while providing all-wheel drive capability.
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red W/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 53,695
- Stock #:
- 3700095B
- VIN:
- JTHGZ1B22N5050156
2022 Lexus IS
350 F Sport RWD
53,695 mi
$37,383
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 18,382
- Stock #:
- U313537A
- VIN:
- JTHGZ1B29P5071282
-$1,015
2023 Lexus IS
350 F SPORT RWD
18,382 mi
$42,855
$41,840
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 472 hp 5L V8
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 45,847
- Stock #:
- V102365A
- VIN:
- JTHAP1D27P5002437
2023 Lexus IS
500 F SPORT Performance Premium RWD
45,847 mi
$55,234
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 260 hp 3.5L V6
- Exterior color:
- Iridium
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 40,247
- Stock #:
- 2P45747
- VIN:
- JTHC81F28M5045747
2021 Lexus IS
300 AWD
40,247 mi
$35,025
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Infrared
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 11,797
- Stock #:
- P5063281
- VIN:
- JTHGZ1B20P5063281
2023 Lexus IS
350 F SPORT RWD
11,797 mi
$45,442
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Iridium
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- 8-Speed Automatic
- Mileage:
- 52,642
- Stock #:
- 5068580P
- VIN:
- JTHBZ1B2XP5068580
2023 Lexus IS
350 F SPORT Design RWD
52,642 mi
$38,198
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 61,657
- Stock #:
- F6A27609-2
- VIN:
- JTHGZ1B23P5059337
2023 Lexus IS
350 F SPORT RWD
61,657 mi
$39,780
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Cloudburst Gray
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 60,769
- Stock #:
- M5040285
- VIN:
- JTHGZ1B29M5040285
2021 Lexus IS
350 F Sport RWD
60,769 mi
$37,215
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Iridium
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Mileage:
- 85,070
- Stock #:
- V5818A
- VIN:
- JTHDA1D23N5122196
2022 Lexus IS
300 RWD
85,070 mi
$31,171
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black w/Black
- Transmission:
- Automatic
- Mileage:
- 52,959
- Stock #:
- M5048212
- VIN:
- JTHGZ1B20M5048212
2021 Lexus IS
350 F Sport RWD
52,959 mi
$34,678
CarGurus Analysis: 2022 Lexus IS
overall
Summary
With 983 currently listed for sale and an average price of $38,352.00, 33.9% of 2022 Lexus IS cars for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Lexus IS 5 / 5 stars.
82.5% of 2022 Lexus IS models on CarGurus are accident-free.
The 2022 Lexus IS combines a luxurious feel with a quiet ride and powerful V6 engine performance, appealing to driving enthusiasts while providing all-wheel drive capability.
Why it stands out
The 2022 Lexus IS stands out in the compact luxury sedan segment for its exceptional combination of performance, comfort, and technology. With nearly all rivals being less expensive, the IS offers an exhilarating driving experience, particularly with the introduction of the 5.0-liter V8 in the IS 500 F Sport Performance model, delivering 472 horsepower. This model is praised not only for its raw power but also for its refined handling dynamics, making it perfect for both daily commutes and spirited drives. Expert reviews highlight features like a user-friendly infotainment system with a touchscreen interface and advanced safety features provided by Lexus Safety System+ 2.5, which contributes to its overall appeal. However, some limitations such as cargo space and noise levels have been noted, though they are often overshadowed by the car's engaging driving experience and luxurious interior.
Other model years to consider
- Average price: $44,144.00
- Good/great deal percentage: 36.3%
- Total listings: 1,337
- Average price: $42,156.00
- Good/great deal percentage: 34.7%
- User rating: 4.8 / 5
- Total listings: 1,219
- Average price: $17,714.00
- Good/great deal percentage: 31.8%
- User rating: 4.56 / 5
- Total listings: 762
This analysis is based on CarGurus' proprietary market data from June 22, 2026, CarGurus experts' opinions, and generative AI.
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Lexus IS Buying Guide: Cost, Reliability, and the Best Years to Buy
Discover the ultimate buying guide for purchasing a used Lexus IS covering each generation since 2001. Whether you're a first-time buyer or a Lexus enthusiast, this comprehensive overview will help you research your next pre-owned Lexus IS.
5.0 Overall rating
Filter by rating
Jessica C
Reviewed a 2022 Lexus IS on Mar 6, 2025
Absolutely love this car. Quiet, luxurious and classy. Has enough power. Only downfall is gas mileage.
Luis D
Reviewed a 2022 Lexus 350 F Sport RWD on Sep 22, 2025
The car is amazing would highly recommend. This car drives like a dream.
John S
Reviewed a 2022 Lexus IS on Sep 27, 2023
Wonderful vehicle very reliable. Basically its a bullet proof engine as long as you maintain the maintenance. Its stylish and resale value is strong.
Anonymous
Reviewed a 2022 Lexus IS on Nov 10, 2023
Can’t get over the quietness of the car city/highway driving. Purchased the Lexus brand for quality and reliability after problems with my previous car. So let’s hope I experience a positive experience from now on
2022 Lexus IS Trims
| Trim type | MSRP |
|---|---|
| 500 F Sport Launch Edition RWD | $67,400 |
| 500 F Sport Performance Premium RWD | $61,350 |
| 300 AWD | $41,125 |
| 350 F SPORT AWD | $45,550 |
| 300 RWD | $39,125 |
| 350 F Sport RWD | $43,550 |
2022 Lexus IS Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2022 Lexus IS prices has changed over time.
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