Used 2021 Lexus IS for Sale Nationwide
482 results
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- Automatic
- Mileage:
- 87,040
- Stock #:
- 116731
- VIN:
- JTHAA1D20M5116731
2021 Lexus IS
300 RWD
87,040 mi
$26,995
- Year:
- 2020
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Ultra White
- Fuel type:
- Gasoline
- Interior color:
- Rioja Red
- Transmission:
- 8-Speed Automatic Overdrive
- Mileage:
- 70,174
- Stock #:
- L5104672
- VIN:
- JTHGA1D24L5104672
2020 Lexus IS
300 RWD
70,174 mi
$25,897
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- 8-Speed Automatic
- Mileage:
- 56,338
- Stock #:
- C7382
- VIN:
- JTHGZ1B22N5054272
-$854
2022 Lexus IS
350 F Sport RWD
56,338 mi
$37,797
$36,943
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black W/Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 54,872
- Stock #:
- N5025517T
- VIN:
- JTHGZ1E2XN5025517
2022 Lexus IS
350 F SPORT AWD
54,872 mi
$37,971
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 260 hp 3.5L V6
- Exterior color:
- White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 69,474
- Stock #:
- IP2394
- VIN:
- JTHA81F2XM5044297
-$1,000
2021 Lexus IS
300 AWD
69,474 mi
$32,786
$31,786
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 260 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- 6-Speed Automatic
- Mileage:
- 79,510
- VIN:
- JTHA81F23M5044318
2021 Lexus IS
300 AWD
79,510 mi
$28,999
- Year:
- 2020
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Silver
- Fuel type:
- Gasoline
- Interior color:
- Chateau
- Transmission:
- 8-Speed Dual Clutch
- Mileage:
- 50,907
- Stock #:
- 7007166
- VIN:
- JTHGA1D2XL5109035
2020 Lexus IS
300 RWD
50,907 mi
$27,700
- Year:
- 2020
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Rioja Red
- Transmission:
- 6-Speed Automatic
- Mileage:
- 49,511
- Stock #:
- PG7303
- VIN:
- JTHGZ1E21L5018078
2020 Lexus IS
350 AWD
49,511 mi
$34,412
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 73,082
- Stock #:
- 057361
- VIN:
- JTHGZ1B25N5057361
2022 Lexus IS
350 F Sport RWD
73,082 mi
$34,899
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White W/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 63,161
- Stock #:
- 044240
- VIN:
- JTHGZ1B27M5044240
2021 Lexus IS
350 F Sport RWD
63,161 mi
$36,694
- Year:
- 2020
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 65,483
- Stock #:
- F45576B
- VIN:
- JTHGZ1E21L5018050
2020 Lexus IS
350 AWD
65,483 mi
$31,983
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black w/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 49,353
- Stock #:
- P052005
- VIN:
- JTHGZ1B22N5052005
-$1,000
2022 Lexus IS
350 F Sport RWD
49,353 mi
$38,900
$37,900
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- White Pearl
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Rioja Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 71,675
- Stock #:
- 5256T
- VIN:
- JTHCA1D21M5113281
2021 Lexus IS
300 RWD
71,675 mi
$28,580
CarGurus Analysis:
2021 Lexus IS
With 462 currently listed for sale and an average price of $35,303.00, 33.3% of 2021 Lexus IS models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Lexus IS 4.62 / 5 stars.
70.8% of 2021 Lexus IS models on CarGurus are accident free.
The 2021 Lexus IS impresses with its stylish design, multiple powertrain options, and great handling, appealing to both luxury buyers and driving enthusiasts.
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red W/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 53,695
- Stock #:
- 3700095B
- VIN:
- JTHGZ1B22N5050156
-$1,010
2022 Lexus IS
350 F Sport RWD
53,695 mi
$38,881
$37,871
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- White
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- 8-Speed Dual Clutch
- Mileage:
- 57,121
- Stock #:
- 8502
- VIN:
- JTHGZ1B2XM5040683
2021 Lexus IS
350 F Sport RWD
57,121 mi
$39,199
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Iridium
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Flare Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 65,367
- Stock #:
- 5044823
- VIN:
- JTHGZ1B29M5044823
2021 Lexus IS
350 F Sport RWD
65,367 mi
$35,625
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Gray
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White W/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 29,119
- Stock #:
- K5823KM
- VIN:
- JTHGZ1B20N5054724
2022 Lexus IS
350 F Sport RWD
29,119 mi
$40,782
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Grecian Water
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black w/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 44,929
- Stock #:
- M5045667
- VIN:
- JTHGZ1B24M5045667
-$1,000
2021 Lexus IS
350 F Sport RWD
44,929 mi
$38,749
$37,749
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 38,138
- Stock #:
- G63016A
- VIN:
- JTHGZ1B25N5057523
-$1,002
2022 Lexus IS
350 F Sport RWD
38,138 mi
$41,789
$40,787
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black w/Black
- Transmission:
- Automatic
- Mileage:
- 52,249
- Stock #:
- PS8850
- VIN:
- JTHGZ1E29N5023564
2022 Lexus IS
350 F SPORT AWD
52,249 mi
$39,747
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black w/Black
- Transmission:
- Automatic
- Mileage:
- 52,959
- Stock #:
- M5048212
- VIN:
- JTHGZ1B20M5048212
-$807
2021 Lexus IS
350 F Sport RWD
52,959 mi
$35,990
$35,183
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Iridium
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- 8-Speed Automatic
- Mileage:
- 68,821
- Stock #:
- N5118709
- VIN:
- JTHDA1D28N5118709
2022 Lexus IS
300 RWD
68,821 mi
$31,111
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Gray
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White W/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 53,588
- Stock #:
- U1251
- VIN:
- JTHGZ1B23M5039584
-$993
2021 Lexus IS
350 F Sport RWD
53,588 mi
$38,690
$37,697
CarGurus Analysis: 2021 Lexus IS
overall
Summary
With 462 currently listed for sale and an average price of $35,303.00, 33.3% of 2021 Lexus IS models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Lexus IS 4.62 / 5 stars.
70.8% of 2021 Lexus IS models on CarGurus are accident free.
The 2021 Lexus IS impresses with its stylish design, multiple powertrain options, and great handling, appealing to both luxury buyers and driving enthusiasts.
Why it stands out
The 2021 Lexus IS distinguishes itself in the compact luxury sedan market with its athletic design and enhanced driveability. In its fourth generation, this model has incorporated feedback from previous iterations, crafting a car that effortlessly balances luxury with sportiness. With multiple powertrain options, including a turbocharged inline-four and a robust V6, the IS delivers an engaging driving experience. Owners appreciate the luxurious feel and safety features, although some have noted the absence of certain modern tech amenities, like real-time GPS tracking and wireless Apple CarPlay. Despite a few criticisms regarding fuel efficiency and tech outdatedness, the overall positive reception from owners reflects the car’s strong emphasis on handling and responsive performance, supported by Lexus's commitment to quality and reliability.
Other model years to consider
- Average price: $38,684.00
- Good/great deal percentage: 35.2%
- User rating: 5 / 5
- Total listings: 971
- Average price: $42,068.00
- Good/great deal percentage: 35.6%
- User rating: 4.8 / 5
- Total listings: 1,223
- Average price: $44,307.00
- Good/great deal percentage: 35.8%
- Total listings: 1,323
This analysis is based on CarGurus' proprietary market data from June 15, 2026, CarGurus experts' opinions, and generative AI.
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The Lexus IS gets a refresh for 2026 with new styling touches, a bigger infotainment display and instrument cluster, and retuned driving dynamics.
Lexus IS Buying Guide: Cost, Reliability, and the Best Years to Buy
Discover the ultimate buying guide for purchasing a used Lexus IS covering each generation since 2001. Whether you're a first-time buyer or a Lexus enthusiast, this comprehensive overview will help you research your next pre-owned Lexus IS.
4.7 Overall rating
Filter by rating
Amy N
Reviewed a 2021 Lexus IS on Aug 14, 2021
Great car, stylish, good value, sporty, and gorgeous to look at. I love the safety and security features. Remote start and speed settings in the app are great features. Missing- GPS tracking in real-time would be great like Tesla vehicles.
Anonymous
Reviewed a 2021 Lexus IS on Feb 11, 2023
This really has a sporty feel. The AWD, 3.5 Liter V6 is definitely the way to go on this vehicle. The Apple Car Play is incredible and makes the GPS option unnecessary. The gauge cluster looks modern and easy to use. The 360 degree cameras are also a great option. The exterior look of this car is beautiful. I have the matador red which is metallic red with the black 19” wheel rims. Very stylish. A very nice riding car.
Robert O
Reviewed a 2021 Lexus IS on Jan 15, 2024
Great car. Luxury , economy, and style. Rides smooth & fast. Mechanically reliable. Lexus is the best!
Jason M
Reviewed a 2021 Lexus IS on Apr 21, 2023
Im a bit partial because mine has every option available. The premium sound package is worth every penny. I hear its bad on gas. I have the AWD V6 which is plenty fast, so I drive it in eco full time. I get 100 miles on 15 dollars of gas @ 3.30 a gallon. Thats bad? Brakes in this car are amazing. They work along with the computer downshifting on hills perfectly. Anyone who has driven a standard before will notice it too. Its just great stock ecu tuning. Not to mention the brakes act in unison with the AWD. The car does not move in the snow (in a good way). Meaning there is no slipping, sliding or the car trying to get traction. It just goes. Also, thanks to the amazing braking system, there is also no real type of sliding when slowing down or stopping. I live in New England, so my car has seen weather of all types. Bad weather is a non factor. With all that being said, I also have snow tires. Which doesnt hurt and helps tremendously. Fun fact, the snow mode also works great during heavy rain.. just a fyi. Lets see. Its quiet, comfortable and the touch screen is perfect. The body lines are also spot on. There is ZERO wind noise. It looks like it spent a lot of time wind tunnel tested. I personally love the lines of the car and the daytime running lights are the best.. hands down. The back Robocop style taillight has been copied by many. The subtle red on the leds nail it. Not to mention the subtilties of just light things. A lot of attention to detail. Lexus listened to its consumers and said we hear you and well work on that. Which, honestly, you have to appreciate. Great car.. Thank you Lexus.
2021 Lexus IS Trims
| Trim type | MSRP |
|---|---|
| 350 F Sport AWD | $44,950 |
| 350 F Sport RWD | $42,950 |
| 300 AWD | $41,050 |
| 300 RWD | $39,050 |
2021 Lexus IS Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Lexus IS prices has changed over time.
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