Used 2021 Lexus IS for Sale near Mississippi

How much does the 2021 Lexus IS cost?

Prices are up 2.27% year-over-year — a sign of continued demand for this model year.

There are 531 listings available, which suggests a modest amount of inventory for shoppers to compare.

Is the 2021 Lexus IS a good car?

Yes — the 4.62/5 user rating points to strong owner satisfaction, and the expert rating is 7.33/10. The model scores 8/10 across Look and feel and Cost effectiveness.

Owners repeatedly praise the stylish design, sporty feel, luxurious feel, handling, and value for money. The overview also frames it as a compact luxury sports sedan aimed at enthusiast drivers and luxury shoppers who want something more engaging than a comfort-first alternative.

The trade-offs are clear: the base engine is described as underwhelming, the transmission as irritating, and the technology as outdated. Even so, the car’s personality is consistent with its mission, and the market still shows 35.4% of listings as good or great deals.

Is the 2021 Lexus IS reliable?

Owners rate it 4.62/5, a strong signal of long-term satisfaction.

The owner summary also points to a dependable, trouble-free ownership experience, with buyers highlighting the car’s quality and value over time. The expert notes reinforce that impression by emphasizing Lexus’ reputation for quality and reliability, along with the brand’s focus on durability and confidence in daily use.

Lexus also includes a 10-year complimentary service-connect subscription and a three-year trial for safety-connect features, which can help with ownership convenience. For used buyers, the main long-term risk is less about basic dependability and more about whether the car’s tech and powertrain feel dated to you over time.

What should I look for when buying a used 2021 Lexus IS?

At 72.9% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.

You should start with a vehicle history report and then prioritize a pre-purchase inspection, especially if the car has had bodywork or any signs of uneven panel fit. Focus on overall condition, because the model’s appeal depends heavily on how well it has been maintained and whether the driving experience still feels tight and refined.

Key things to evaluate:

• Trim level: The IS 300 RWD emphasizes the cleaner rear-wheel-drive setup, while the IS 300 AWD adds all-weather traction and a different engine layout. The IS 350 F Sport trims bring the more performance-oriented look and stronger output, so the base trims are the ones most likely to feel light on excitement and equipment.
• Powertrain: The IS 300 RWD uses a 2.0-liter turbocharged four-cylinder with 241 horsepower and 258 pound-feet of torque, while the IS 300 AWD uses a 3.5-liter V6 with 260 hp and 236 lb-ft. The IS 350 versions use the V6 tuned to 311 hp and 280 lb-ft, with RWD models paired to an eight-speed automatic and AWD models to a six-speed automatic.
• Safety package: Lexus Safety System+ 2.5 is standard and includes pre-collision with pedestrian detection, low-light pedestrian detection, daytime bicyclist detection, left-turn intersection support, lane-departure warning with steering assist, road-sign recognition, enhanced lane-tracing assist, full-speed dynamic adaptive cruise control, and intelligent high beams. It also includes blind-spot monitoring with rear cross-traffic alert, a backup camera with dynamic gridlines, and Lexus Enform Safety Connect.
• Infotainment: The IS finally gets a touchscreen infotainment system with Android Auto and Apple CarPlay. Lexus also includes connected services such as Service Connect, Remote, and WiFi trials, but the subscription structure is something you should understand before you buy.
• Fuel efficiency: The IS 300 RWD is rated at 21 mpg city, 31 mpg highway, and 25 mpg combined; the IS 300 AWD at 19/26/22; the IS 350 RWD at 20/28/23; and the IS 350 AWD at 19/26/22.

Which 2021 Lexus IS trim should I buy?

The 2021 Lexus IS is offered in 4 trim levels: IS 300 RWD, IS 300 AWD, IS 350 RWD F Sport, IS 350 AWD F Sport.

Here's the short version:

• IS 300 RWD: This is the least expensive way into the lineup and the best fit if you want the rear-wheel-drive layout and the lowest starting price. It gives you the core IS experience without stepping up to the more expensive F Sport models.
• IS 300 AWD: Choose this if you want the added traction of all-wheel drive and are willing to pay more for it. It makes sense if you value the AWD setup more than the lower entry price of the RWD model.
• IS 350 RWD F Sport: This is the best-value choice if you want the stronger 311-hp V6 and the more athletic F Sport character without paying for AWD. It is the trim that most clearly matches the car’s sporty mission.
• IS 350 AWD F Sport: Pick this if you want the strongest available all-weather version of the lineup and do not mind the highest price. It is the most expensive trim and best suited to buyers who want the full performance-oriented package with AWD.

Lexus Safety System+ 2.5 is standard across the lineup.

Is now a good time to buy a used 2021 Lexus IS?

This looks like a moderate, selective-buyer market, so you have room to shop carefully rather than rush.

• Deal availability: 35.4% of listings are priced as good or great deals.
• Inventory: There are 531 listings available.
• Price trend: Prices are up 2.27% year-over-year.
• Clean inventory: 72.9% of listings are accident-free.

If you find a listing below $33,101, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Lexus IS's resale value?

The current average of $34,672 sits slightly above last year's $33,901.

That upward move suggests the model has held demand reasonably well, which is helpful if you plan to sell later. The fact that prices are still above the prior-year average also points to a market that continues to value the IS’s styling and driving character.

For a future seller, that means a well-kept example should remain competitive if it presents cleanly and has a solid history. Strong condition and desirable equipment should matter, especially because shoppers in this segment often compare multiple luxury sedans side by side.

Vehicles with strong owner satisfaction ratings, like this model year's 4.62/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Lexus IS safe?

The 2021 Lexus IS hasn’t yet been rated for crashworthiness by IIHS, nor has it received an overall rating from NHTSA.

It earns a 7/10 safety score from our experts.

Lexus Safety System+ 2.5 is standard, and it includes pre-collision with pedestrian detection, low-light pedestrian detection, daytime bicyclist detection, left-turn intersection support, lane-departure warning with steering assist, road-sign recognition, enhanced lane-tracing assist, full-speed dynamic adaptive cruise control, and intelligent high beams. It also adds blind-spot monitoring with rear cross-traffic alert, a backup camera with dynamic gridlines, and Lexus Enform Safety Connect.

The main caveat is that the car lacks formal crash-test results in the data here, so you should lean more heavily on the standard driver-assistance equipment and the vehicle’s condition when shopping used.

Should I buy a 2021 Lexus IS or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 35.4% of listings are priced as good or great deals.
• At 72.9% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.
• Price trend: Prices are up 2.27% year-over-year.
• Owners rate it 4.62/5 — a strong satisfaction signal.
• The 2021 marks the IS’s fourth generation and brings a sharper, more purpose-built driving character.

Consider the 2022 if:

• At $37,516, the 2022 costs more than the current year's $34,672 average.
• It adds the new IS 500 F Sport Performance with a V8 and much stronger performance.

The bottom line: If you want the better value and the core redesign year, the 2021 is the smarter buy. If you care more about maximum performance and can spend more, the 2022 is the better path. For price-sensitive buyers, the 2021 remains the sweet spot because it delivers the refreshed generation without the higher average price of the next year.

These recommendations are based on CarGurus' proprietary market data from September 22, 2026, CarGurus experts' opinions, and generative AI.