Will it damage the transmission to drive with the overdrive on?
No. matter of fact you normally drive with Overdrive on except if you are going up or down a steep grade, especially with a heavy load of passengers and cargo, and some folks kick it out of O/D driving around town when you don't get over 45 or so. But at highway speeds it should be 'on' it gives you an extra gear
Looking for a Used Escape in your area?
CarGurus has 88,367 nationwide Escape listings starting at $1,088.
Search Ford Escape Questions
Ford Escape Experts