2021 Toyota Sienna vs 2021 Mercedes-Benz GLS
Overview | |
MSRP$76,000 | MSRP$34,460 |
Listings281 | Listings688 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews8.3 out of 10 | Expert reviews8.3 out of 10 |
Pros
Cons
| Pros
Cons
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2021 Mercedes-Benz GLS Reviews SummaryThe “S” in the 2021 Mercedes-Benz GLS-Class name is meant to connect the SUV to the S-Class flagship sedan. In this sense, the GLS is the S-Class of SUVs, and it delivers on that positioning. The 2021 GLS-Class has three rows of spacious seating, and puts comfort above all else. The GLS can hold groceries, weekend bags, antique desks purchased from a roadside consignment shop—all things that would require a lot of negotiating in the S-Class sedan. The GLS-Class is one member of a growing fraternity of full-size, three-row, luxury SUVs. Their ranks include the Cadillac Escalade, Lincoln Navigator, Infiniti QX80, and the more recent BMW X7. The GLS sets itself apart with a higher standard of luxury, and impressive performance… if you’re willing to shell out the cash. | |
2021 Toyota Sienna Reviews SummaryToyota’s minivan got a major makeover for 2021, now entering its fourth generation of production since debuting as a 1997 model. For the first time, the Sienna gets a hybrid gasoline-electric powertrain, and not only that—it’s standard equipment. The Sienna Hybrid is built on the Toyota New Global Architecture (TNGA-K) platform, shared with the Highlander and other current Toyota models. | |
No video found | |
Popular Features & Specs | |
Engine3.0L 362 hp I6 | Engine2.5L 245 hp I4 Hybrid |
Drive TrainAWD | Drive TrainFWD |
Seating Capacity7 | Seating Capacity8 |
Horsepower362 hp @ 5500 rpm | Horsepower |
EV Battery Capacity | EV Battery Capacity1.9 kWh |
MPG City20 | MPG City36 |
MPG Highway24 | MPG Highway36 |
Engine | |
Engine Name3.0L 362 hp I6 | Engine Name2.5L 245 hp I4 Hybrid |
Torque369 lb-ft @ 1600 rpm | Torque |
Horsepower362 hp @ 5500 rpm | Horsepower |
DrivetrainAWD | DrivetrainFWD |
Fuel Economy | |
EV Battery Capacity | EV Battery Capacity1.9 kWh |
MPG City20 | MPG City36 |
MPG Highway24 | MPG Highway36 |
Interior | |
Seating Capacity7 | Seating Capacity8 |
Key Features | |
Navigation SystemStandard | Navigation System |
Sunroof/MoonroofStandard | Sunroof/Moonroof |
Safety | |
Front Crash Overall | Front Crash Overall4 |
Side Crash Overall | Side Crash Overall5 |
Dimensions & Capacity | |
Cargo Space17.4 cu ft | Cargo Space33.5 cu ft |
Curb Weight5467 lbs | Curb Weight4610 lbs |
Height72.4 in | Height68.5 in |
Length205.0 in | Length203.7 in |
Width84.9 in | Width78.5 in |
Wheelbase123.4 in | Wheelbase120.5 in |
Maximum Payload1808 lbs | Maximum Payload1560 lbs |
Number of doors4 | Number of doors4 |
Maximum Towing Capacity7700 lbs | Maximum Towing Capacity3500 lbs |
Overview | ||
MSRP | $76,000 | $34,460 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 8.3 out of 10Read full review | 8.3 out of 10Read full review |
Pros & cons | Pros
Cons
| Pros
Cons
|
Summary | The “S” in the 2021 Mercedes-Benz GLS-Class name is meant to connect the SUV to the S-Class flagship sedan. In this sense, the GLS is the S-Class of SUVs, and it delivers on that positioning. The 2021 GLS-Class has three rows of spacious seating, and puts comfort above all else. The GLS can hold groceries, weekend bags, antique desks purchased from a roadside consignment shop—all things that would require a lot of negotiating in the S-Class sedan. The GLS-Class is one member of a growing fraternity of full-size, three-row, luxury SUVs. Their ranks include the Cadillac Escalade, Lincoln Navigator, Infiniti QX80, and the more recent BMW X7. The GLS sets itself apart with a higher standard of luxury, and impressive performance… if you’re willing to shell out the cash. | Toyota’s minivan got a major makeover for 2021, now entering its fourth generation of production since debuting as a 1997 model. For the first time, the Sienna gets a hybrid gasoline-electric powertrain, and not only that—it’s standard equipment. The Sienna Hybrid is built on the Toyota New Global Architecture (TNGA-K) platform, shared with the Highlander and other current Toyota models. |
Video | No video found | |
Popular Features & Specs | ||
Engine | 3.0L 362 hp I6 | 2.5L 245 hp I4 Hybrid |
Drive Train | AWD | FWD |
Seating Capacity | 7 | 8 |
Horsepower | 362 hp @ 5500 rpm | |
EV Battery Capacity | 1.9 kWh | |
MPG City | 20 | 36 |
MPG Highway | 24 | 36 |
Engine | ||
Engine Name | 3.0L 362 hp I6 | 2.5L 245 hp I4 Hybrid |
Torque | 369 lb-ft @ 1600 rpm | |
Horsepower | 362 hp @ 5500 rpm | |
Drivetrain | AWD | FWD |
Fuel Economy | ||
EV Battery Capacity | 1.9 kWh | |
MPG City | 20 | 36 |
MPG Highway | 24 | 36 |
Interior | ||
Seating Capacity | 7 | 8 |
Key Features | ||
Navigation System | Standard | |
Sunroof/Moonroof | Standard | |
Safety | ||
Front Crash Overall | 4 | |
Side Crash Overall | 5 | |
Dimensions & Capacity | ||
Cargo Space | 17.4 cu ft | 33.5 cu ft |
Curb Weight | 5467 lbs | 4610 lbs |
Height | 72.4 in | 68.5 in |
Length | 205.0 in | 203.7 in |
Width | 84.9 in | 78.5 in |
Wheelbase | 123.4 in | 120.5 in |
Maximum Payload | 1808 lbs | 1560 lbs |
Number of doors | 4 | 4 |
Maximum Towing Capacity | 7700 lbs | 3500 lbs |
The 2021 Mercedes-Benz GLS, a continuation of the third generation introduced in 2020, was a luxurious SUV that evolved from the original GL-Class. Initially intended to replace the G-Class, the GLS found its niche among affluent families seeking a more practical yet opulent alternative to the likes of the Navigator and Escalade. The GLS's design was more refined and less imposing than its predecessors, with softened angles and a sleek appearance. Inside, it boasted a futuristic cabin dominated by a massive digital screen, emphasizing its tech-centric nature. The GLS lineup included the GLS 450, GLS 580, and the high-performance AMG GLS 63, each offering a range of luxurious features and options to enhance comfort and convenience.
In contrast, the 2021 Toyota Sienna Hybrid aimed to redefine the minivan's image with a more SUV-like appearance. Its wide grille and sleek LED headlamps contributed to a modern look, while the sculpted sliding side doors added a touch of sophistication. The Sienna's interior emphasized width and comfort, with a higher seating position and a simple, uncluttered dashboard. The second and third rows provided ample space for passengers, and the cabin featured numerous storage options, including a smartly designed center console. The Sienna's design and functionality made it a practical choice for families, offering a blend of style and utility.
















The 2021 Mercedes-Benz GLS offered a range of powerful engine options. The entry-level GLS 450 featured a twin-turbocharged 3.0-liter inline-six engine, producing 362 horsepower and 369 pound-feet of torque. The GLS 580 upgraded to a twin-turbocharged 4.0-liter V8, delivering 483 horsepower and 516 pound-feet of torque. Both models utilized a nine-speed automatic transmission and Mercedes' 4MATIC all-wheel-drive system. The AMG GLS 63, with its hand-crafted 4.0-liter twin-turbo V8 engine, generated an impressive 603 horsepower and 627 pound-feet of torque. This powerhouse could accelerate from zero to 60 mph in just 4.1 seconds, reaching a top speed of 174 mph. The GLS 63 featured an adaptive air suspension system, multiple drive modes, and E-Active Body Control for a smooth and composed ride.
The 2021 Toyota Sienna Hybrid marked Toyota's first hybrid minivan, combining a 2.5-liter four-cylinder engine with two electric motors to produce 243 horsepower. Front-wheel drive was standard, with all-wheel drive available on all trims. The Sienna utilized an electronically controlled continuously variable automatic transmission (CVT), which prioritized fuel efficiency over throttle response. The Sienna Hybrid's handling was improved with new front suspension and steering, providing a comfortable and stable ride. Its standout feature was its impressive fuel economy, with FWD models achieving 36 mpg city, 36 mpg highway, and 36 mpg combined, while AWD models were rated at 35/36/35 mpg combined.
The 2021 Mercedes-Benz GLS offered three rows of spacious seating, accommodating up to seven passengers, with optional second-row captain's chairs reducing capacity to six. The front and second-row seats provided ample headroom and legroom, while the third row was suitable for adults. The GLS boasted 17.4 cubic feet of cargo space behind the third row, expanding to 42.7 cubic feet with the third row folded, and 87.4 cubic feet with both the second and third rows down. The interior featured numerous storage compartments, including a center console with butterfly doors.
The 2021 Toyota Sienna excelled in convenience and cargo handling. It featured a standard third-row 60/40-split bench that easily stored away, and the second row could slide up to 25 inches for easy access. The Sienna's cabin offered 16 cupholders and ample storage cubbies. It could accommodate a full four-by-eight sheet of plywood with the tailgate closed, with cargo space measuring 33.5 cubic feet behind the third row, 75.2 cubic feet behind the second row, and 101.0 cubic feet behind the first row. The Sienna's hybrid battery was cleverly tucked under the front seats, preserving cargo space.
The 2021 Mercedes-Benz GLS featured the MBUX infotainment system, with a massive touch screen and a trackpad for navigation. It included Apple CarPlay and Android Auto, though a USB-C cable was required for connection. The MBUX system offered voice control, activated by saying "Mercedes" or "Hey Mercedes," and a digital dash that extended to the instrument panel. The system was controlled via touch-sensitive pads on the steering wheel, providing a customizable and tech-savvy experience.
The 2021 Toyota Sienna came equipped with a nine-inch touchscreen, offering Apple CarPlay, Android Auto, Amazon Alexa, and SiriusXM. It included a year's trial of Safety Connect and Remote Connect, a ten-year trial of Service Connect, and a three-month trial of AT&T WiFi Connect. Higher trims featured a Premium Audio + JBL package with 12 speakers and a rear-seat entertainment system. The driver enjoyed a color multi-information display, with a 10-inch Head-Up Display available on Platinum models. The Sienna also offered a digital rearview mirror and remote keyless entry with push-button start.
The 2021 Mercedes-Benz GLS came standard with a comprehensive suite of driver-assistance features, including Active Brake Assist, forward-collision avoidance, rain-sensing wipers, blind-spot monitoring, and automatic high beams. Additional safety tech included lane-keep assist, lane-change assist, adaptive cruise control, and stop-and-go cruise control. The GLS was equipped with front-and-side-impact airbags, traction control, self-tensioning seatbelts, and a tire-pressure monitoring system.
The 2021 Toyota Sienna Hybrid featured Toyota Safety Sense 2.0, which included dynamic radar cruise control, lane-tracing assist, pre-collision system with pedestrian and bicyclist detection, lane-departure alert, automatic high beams, and road sign assist. The Sienna also had the Star Safety System, 10 airbags, and LATCH connectors. A rear-seat reminder system and tire pressure monitoring system were standard. While crash-test ratings for the 2021 model were not yet available, the 2020 Sienna received favorable ratings from IIHS and NHTSA.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz GLS is 8.3 out of 10, while the 2021 Toyota Sienna scores 8.3 out of 10. Both vehicles offer unique strengths, but the Sienna's combination of fuel efficiency, practicality, and family-friendly features make it a compelling choice for those seeking a versatile and economical vehicle.
Choose the 2021 Toyota Sienna if:
- You need a family-friendly vehicle with excellent fuel efficiency and hybrid technology.
- You value practicality and cargo space for versatile transportation needs.
- You want a minivan with a comprehensive suite of safety features and modern technology.
Choose the 2021 Mercedes-Benz GLS if:
- You desire a luxury SUV with powerful engine options and impressive performance.
- You prioritize advanced technology and a high-tech infotainment system.
- You seek a spacious and comfortable interior with premium features.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz GLS is 8.3 out of 10, while the 2021 Toyota Sienna scores 8.3 out of 10. Both vehicles offer unique strengths, but the Sienna's combination of fuel efficiency, practicality, and family-friendly features make it a compelling choice for those seeking a versatile and economical vehicle.
Choose the 2021 Toyota Sienna if:
Shop Now- You need a family-friendly vehicle with excellent fuel efficiency and hybrid technology.
- You value practicality and cargo space for versatile transportation needs.
- You want a minivan with a comprehensive suite of safety features and modern technology.
Choose the 2021 Mercedes-Benz GLS if:
Shop Now- You desire a luxury SUV with powerful engine options and impressive performance.
- You prioritize advanced technology and a high-tech infotainment system.
- You seek a spacious and comfortable interior with premium features.

By: CarGurus + AI
At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.








































