Would you take this car on a trip like this? (See explanation)

Here are the details: 2005 Chrysler Town and Country van. 3.3L engine.
155,000 miles. Has had no major mechanical problems to date. Recently
replaced radiator and hoses.

Would you take this van on a 3,500 mile journey? The journey will be mostly
major highways. I guess I'm just concerned that a trip of this length (and
given the van's age and miles) would potentially cause mechanical issues. My
other option is renting a car.

Thanks for the advice.