2021 Mercedes-Benz S-Class vs 2022 Acura TLX
Overview | |
MSRP$109,800 | MSRP$38,900 |
Listings196 | Listings283 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews7.5 out of 10 | Expert reviews7.5 out of 10 |
Pros
Cons
| Pros
Cons
|
2021 Mercedes-Benz S-Class Reviews SummaryThe S-Class not only sits at the top of the Mercedes hierarchy in price and prestige, but it has also long served as a technological showcase. In the press release for the redesigned 2021 S-Class, Mercedes repeatedly noted the innovations—from anti-lock brakes to airbags—that were introduced on the big sedan and eventually trickled down to mainstream vehicles. With the previous generation dating back to the 2014 model year (with a significant update for 2018), the Mercedes-Benz S-Class was in need of an update to maintain that status, and to keep pace with other full-size luxury sedans like the Audi A8, BMW 7 Series, and Lexus LS. To do that, the new S-Class gets a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork, among other features. The 2021 S-Class launches in two configurations, both with 4Matic all-wheel drive (AWD) and EQ Boost mild-hybrid systems. The S500 4Matic has a six-cylinder engine, while the S580 4Matic has a V8. We spent a few days with the Mercedes-Benz S580 for this review. A Mercedes-Maybach S680 4Matic version will follow in the first half of 2022, and you can expect a new AMG performance version sometime in the future as well. | |
2022 Acura TLX Reviews SummaryAcura is a luxury brand with a lineup that hasn't felt unique or luxurious for many years. However, the design renaissance within Acura, starting with the 2021 TLX sedan and 2022 MDX SUV, is quickly changing that impression. Unchanged for 2022, the TLX has road presence, intense attention to detail, and genuine performance capability that lifts it significantly above Honda models at a reasonable premium. We tested an Acura TLX Type S—an impressionable name last seen in 2008—on the road and the race track. | |
Popular Features & Specs | |
Engine3.0L 429 hp I6 | Engine2.0L 272 hp I4 |
Drive TrainAWD | Drive TrainFWD |
Seating Capacity5 | Seating Capacity5 |
Horsepower429 hp @ 6100 rpm | Horsepower272 hp @ 6500 rpm |
MPG City20 | MPG City22 |
MPG Highway29 | MPG Highway31 |
Engine | |
Engine Name3.0L 429 hp I6 | Engine Name2.0L 272 hp I4 |
Torque384 lb-ft @ 1800 rpm | Torque280 lb-ft @ 1600 rpm |
Horsepower429 hp @ 6100 rpm | Horsepower272 hp @ 6500 rpm |
DrivetrainAWD | DrivetrainFWD |
Fuel Economy | |
MPG City20 | MPG City22 |
MPG Highway29 | MPG Highway31 |
Interior | |
Leather SeatsOptional | Leather Seats |
Seating Capacity5 | Seating Capacity5 |
Key Features | |
Navigation SystemOptional | Navigation System |
Sunroof/MoonroofOptional | Sunroof/MoonroofStandard |
Safety | |
Front Crash Overall | Front Crash Overall5 |
Side Crash Overall | Side Crash Overall5 |
Dimensions & Capacity | |
Cargo Space12.9 cu ft | Cargo Space13.5 cu ft |
Curb Weight4740 lbs | Curb Weight3709 lbs |
Height59.2 in | Height56.4 in |
Length208.2 in | Length194.6 in |
Width83.0 in | Width75.2 in |
Wheelbase126.6 in | Wheelbase113.0 in |
Maximum Payload | Maximum Payload838 lbs |
Number of doors4 | Number of doors4 |
Overview | ||
MSRP | $109,800 | $38,900 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 7.5 out of 10Read full review | 7.5 out of 10Read full review |
Pros & cons | Pros
Cons
| Pros
Cons
|
Summary | The S-Class not only sits at the top of the Mercedes hierarchy in price and prestige, but it has also long served as a technological showcase. In the press release for the redesigned 2021 S-Class, Mercedes repeatedly noted the innovations—from anti-lock brakes to airbags—that were introduced on the big sedan and eventually trickled down to mainstream vehicles. With the previous generation dating back to the 2014 model year (with a significant update for 2018), the Mercedes-Benz S-Class was in need of an update to maintain that status, and to keep pace with other full-size luxury sedans like the Audi A8, BMW 7 Series, and Lexus LS. To do that, the new S-Class gets a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork, among other features. The 2021 S-Class launches in two configurations, both with 4Matic all-wheel drive (AWD) and EQ Boost mild-hybrid systems. The S500 4Matic has a six-cylinder engine, while the S580 4Matic has a V8. We spent a few days with the Mercedes-Benz S580 for this review. A Mercedes-Maybach S680 4Matic version will follow in the first half of 2022, and you can expect a new AMG performance version sometime in the future as well. | Acura is a luxury brand with a lineup that hasn't felt unique or luxurious for many years. However, the design renaissance within Acura, starting with the 2021 TLX sedan and 2022 MDX SUV, is quickly changing that impression. Unchanged for 2022, the TLX has road presence, intense attention to detail, and genuine performance capability that lifts it significantly above Honda models at a reasonable premium. We tested an Acura TLX Type S—an impressionable name last seen in 2008—on the road and the race track. |
Video | ||
Popular Features & Specs | ||
Engine | 3.0L 429 hp I6 | 2.0L 272 hp I4 |
Drive Train | AWD | FWD |
Seating Capacity | 5 | 5 |
Horsepower | 429 hp @ 6100 rpm | 272 hp @ 6500 rpm |
MPG City | 20 | 22 |
MPG Highway | 29 | 31 |
Engine | ||
Engine Name | 3.0L 429 hp I6 | 2.0L 272 hp I4 |
Torque | 384 lb-ft @ 1800 rpm | 280 lb-ft @ 1600 rpm |
Horsepower | 429 hp @ 6100 rpm | 272 hp @ 6500 rpm |
Drivetrain | AWD | FWD |
Fuel Economy | ||
MPG City | 20 | 22 |
MPG Highway | 29 | 31 |
Interior | ||
Leather Seats | Optional | |
Seating Capacity | 5 | 5 |
Key Features | ||
Navigation System | Optional | |
Sunroof/Moonroof | Optional | Standard |
Safety | ||
Front Crash Overall | 5 | |
Side Crash Overall | 5 | |
Dimensions & Capacity | ||
Cargo Space | 12.9 cu ft | 13.5 cu ft |
Curb Weight | 4740 lbs | 3709 lbs |
Height | 59.2 in | 56.4 in |
Length | 208.2 in | 194.6 in |
Width | 83.0 in | 75.2 in |
Wheelbase | 126.6 in | 113.0 in |
Maximum Payload | 838 lbs | |
Number of doors | 4 | 4 |
The 2021 Mercedes-Benz S-Class retained a familiar exterior design, but with significant aerodynamic improvements, boasting a drag coefficient of 0.22. It was slightly larger than its predecessor, with a longer wheelbase and increased height and width. The car's size was imposing, complemented by the classic Mercedes hood ornament and grille. Standard 19-inch wheels could be upgraded to 20-inch or 21-inch options, with the 20-inch wheels providing a balanced look. Inside, the S-Class featured a minimalist design centered around a large infotainment touchscreen and digital instrument cluster, with ambient lighting that included 250 LED elements in 64 colors. High-quality materials like Nappa leather and open-pore wood trim were standard, though the piano-black trim was prone to smudging and reflections.
The 2022 Acura TLX had a wide and long stance, making it appear larger than its class competitors. It was notably wider than the BMW 3 Series, with a design that included thin headlights, a five-sided grille, and large tailpipes. The Type S variant added unique features like Tiger Eye Pearl paint, Performance Red Pearl, and 20-inch Y-spoke gray wheels inspired by the Acura NSX. The TLX's interior was snug, with impressive detailing and a Scandinavian lounge vibe in upper trims. The Type S featured faux-suede inserts, red stitching, and a flat-bottom steering wheel with real metal shift paddles. The TLX's daring color options set it apart from competitors like Audi and Lexus.
















The 2021 Mercedes-Benz S-Class offered two engine options: a 3.0-liter turbocharged inline-six in the S500 4Matic, producing 429 horsepower and 384 pound-feet of torque, and a 4.0-liter twin-turbo V8 in the S580 4Matic, delivering 496 hp and 516 lb-ft of torque. Both engines featured EQ Boost, a mild-hybrid system adding 21 hp and 184 lb-ft of torque for short bursts. The S500 accelerated from 0 to 60 mph in 4.8 seconds, while the S580 did it in 4.4 seconds, with both models electronically limited to a top speed of 130 mph. The S-Class came with standard air suspension and an optional E-Active Body Control suspension system. Rear-wheel steering was also available, reducing the turning circle by seven feet. The S580 provided a fast and comfortable ride, with precise steering and well-controlled body roll in Sport and Sport+ modes.
The 2022 Acura TLX featured a 2.0-liter turbocharged inline-four engine producing 272 horsepower and 280 pound-feet of torque, paired with a 10-speed automatic transmission. The TLX offered front-wheel drive as standard, with the option to upgrade to Super Handling-All Wheel Drive (SH-AWD) for $2000. The Type S variant came with a 3.0-liter turbo V6 engine, generating 355 hp and 354 lb-ft of torque. The TLX's SH-AWD system improved stability and handling precision by varying torque at the rear wheels. The Type S excelled on the track, with a double-wishbone front suspension, adaptive dampers, and Pirelli P Zero summer tires. The engine's broad torque and minimal turbo lag made for an engaging driving experience, though the exhaust note was subdued. The regular TLX was more softly sprung, offering a comfortable ride but lacking the sportiness of the Type S. Fuel economy for the Type S was 19 mpg city, 24 mpg highway, and 21 mpg combined.
The 2021 S-Class offered more front and rear headroom and rear legroom than its predecessor, with segment-leading shoulder room. Cargo space increased to 12.9 cubic feet, though it remained less than other luxury sedans. The front seats featured 19 motors for adjustment, heating, ventilation, and massage, with tiny pillows on the head restraints. The center console provided ample storage, including a wireless phone charger and cupholders. Rear-seat passengers enjoyed a large console with cupholders and climate controls, with the optional Executive Line package adding power-adjustable rear seats and four-zone climate control.
The 2022 TLX, despite its large exterior, had a tight interior for four passengers. The back seat offered decent headroom but limited legroom. The front seats were comfortable, with the Type S featuring thigh extensions and adjustable side bolsters. The driving position was low, with well-marked controls. The touchpad interface for the infotainment system required acclimation, as it was not a traditional touchscreen. Trunk space was 13.5 cubic feet, less than a Honda Civic, and the double-wishbone suspension took up additional space.
The 2021 S-Class came with a 12.3-inch digital instrument cluster and a 12.8-inch OLED central touchscreen, featuring wireless Apple CarPlay and Android Auto, and six USB ports. An optional 30-speaker Burmester audio system and rear-seat infotainment setup with 11.6-inch touchscreens were available. The updated MBUX infotainment system offered increased computing power and a more touchscreen-reliant interface. The S-Class also featured an augmented-reality head-up display and biometric or facial recognition for personal profiles. However, the digital instrument cluster's small touchpads and the ambient lighting's reactive features were less impressive.
The 2022 TLX's infotainment interface was simple and quick, though some typefaces were too small to read. The head-up display, available only with the Advance Package, allowed interaction with various functions from the steering wheel. The ELS Studio audio system with 17 speakers was included, along with voice recognition, Apple CarPlay, Android Auto, SiriusXM, and 12-way heated front seats. The Technology Package linked climate control to navigation and included standard features like LED headlights and a garage door opener. The AcuraWatch suite of driver assistance features provided semi-automated control on marked highways.
The 2021 S-Class had not been rated by the NHTSA or IIHS, but it included numerous safety features, such as a rear-passenger airbag, adaptive cruise control, automated lane centering, automatic emergency braking, forward-collision warning, blind-spot monitoring, lane-keep assist, lane-change assist, traffic-sign recognition, a driver-attention monitor, and a 360-degree camera system. Mercedes claimed improvements in these features, with better traffic-sign recognition and lane-keep assist. The adaptive cruise control and lane-centering systems performed well, handling highway curves and reacting smoothly to traffic changes.
The 2022 TLX received a Top Safety Pick+ rating from the IIHS and a five-star overall score from the NHTSA. Standard safety features included knee airbags, a unique passenger airbag, lane-keep assist, adaptive cruise control, auto high beams, and traffic-sign recognition. Blind-spot monitoring, rear cross-traffic alert, and parking sensors were included in the Technology Package and higher trims.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz S-Class is 7.5 out of 10, while the 2022 Acura TLX scores 7.5 out of 10. Both vehicles offer unique strengths, but the final recommendation depends on your priorities. If you seek luxury, advanced technology, and a spacious interior, the Mercedes-Benz S-Class is the better choice. However, if you value sporty performance, a well-designed interior, and a high safety rating, the Acura TLX is the way to go.
Choose the 2021 Mercedes-Benz S-Class if:
- You prioritize a luxurious and spacious interior with advanced comfort features.
- You want a vehicle with cutting-edge technology and a high level of customization.
- You seek a smooth and comfortable ride with precise handling.
Choose the 2022 Acura TLX if:
- You prefer a sporty driving experience with advanced handling capabilities.
- You value a well-designed and detailed interior with unique color options.
- You want a vehicle with a high safety rating and comprehensive driver assistance features.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz S-Class is 7.5 out of 10, while the 2022 Acura TLX scores 7.5 out of 10. Both vehicles offer unique strengths, but the final recommendation depends on your priorities. If you seek luxury, advanced technology, and a spacious interior, the Mercedes-Benz S-Class is the better choice. However, if you value sporty performance, a well-designed interior, and a high safety rating, the Acura TLX is the way to go.
Choose the 2021 Mercedes-Benz S-Class if:
Shop Now- You prioritize a luxurious and spacious interior with advanced comfort features.
- You want a vehicle with cutting-edge technology and a high level of customization.
- You seek a smooth and comfortable ride with precise handling.
Choose the 2022 Acura TLX if:
Shop Now- You prefer a sporty driving experience with advanced handling capabilities.
- You value a well-designed and detailed interior with unique color options.
- You want a vehicle with a high safety rating and comprehensive driver assistance features.

By: CarGurus + AI
At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.








































