2021 Mercedes-Benz E-Class vs 2022 Mercedes-Benz S-Class
Overview | |
MSRP$54,250 | MSRP$111,100 |
Average price$41,713 | Average price$76,439 |
Listings410 | Listings437 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews8.3 out of 10 | Expert reviews8.7 out of 10 |
Pros
| Pros
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2021 Mercedes-Benz E-Class Reviews SummaryWhen money is but a mild concern, a brand-new Mercedes-Benz is a reasonable purchase. The E-Class is the company's most practical and versatile car, as high-quality and necessary in a nice garage as a Kitchen-Aid mixer is in a baker's kitchen. It offers four body styles, four engines, and dozens of color schemes. Fast or efficient? Loud or library quiet? Modest or rich as hell? The E-Class is all of those things, depending on which of the 13 models you order and how deep into the options list you dive. For 2021, the E-Class receives a mid-cycle update for the infotainment system, engines, and exterior styling. We tested the AMG E53 that features a mild-hybrid inline-six powertrain. | |
2022 Mercedes-Benz S-Class Reviews SummaryThe 2022 Mercedes-Benz S-Class is a full-size four-door luxury sedan with a 48-volt mild hybrid gasoline-electric powertrain, including a turbocharged 3.0-liter inline six-cylinder gas engine (S500) or twin-turbo 4.0-liter V8 (S580), with EQ Boost, a nine-speed automatic transmission, and all-wheel drive (AWD). The S500 starts at $111,100; the S580 starts at $117,700. The EPA estimates the S500 can achieve fuel economy of up to 21 mpg city/30 mpg highway/24 mpg combined, while the S580 is rated at 16 mpg city/25 mpg highway/19 mpg combined. | |
No video found | |
Popular Features & Specs | |
Engine2.0L 255 hp I4 | Engine3.0L 429 hp I6 |
Drive TrainRWD | Drive TrainAWD |
Seating Capacity5 | Seating Capacity5 |
Horsepower255 hp @ 5800 rpm | Horsepower429 hp @ 6100 rpm |
MPG City22 | MPG City21 |
MPG Highway31 | MPG Highway30 |
Engine | |
Engine Name2.0L 255 hp I4 | Engine Name3.0L 429 hp I6 |
Torque273 lb-ft @ 1800 rpm | Torque384 lb-ft @ 1800 rpm |
Horsepower255 hp @ 5800 rpm | Horsepower429 hp @ 6100 rpm |
DrivetrainRWD | DrivetrainAWD |
Fuel Economy | |
MPG City22 | MPG City21 |
MPG Highway31 | MPG Highway30 |
Interior | |
Leather Seats | Leather SeatsOptional |
Seating Capacity5 | Seating Capacity5 |
Key Features | |
Navigation SystemStandard | Navigation SystemOptional |
Sunroof/MoonroofStandard | Sunroof/MoonroofOptional |
Safety | |
Front Crash Overall5 | Front Crash Overall |
Side Crash Overall5 | Side Crash Overall |
Dimensions & Capacity | |
Cargo Space13.1 cu ft | Cargo Space12.9 cu ft |
Curb Weight3781 lbs | Curb Weight4740 lbs |
Height57.8 in | Height59.2 in |
Length194.3 in | Length208.2 in |
Width81.3 in | Width83.0 in |
Wheelbase115.7 in | Wheelbase126.6 in |
Maximum Payload | Maximum Payload1387 lbs |
Number of doors4 | Number of doors4 |
Overview | ||
MSRP | $54,250 | $111,100 |
Average price | $41,713 | $76,439 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 8.3 out of 10Read full review | 8.7 out of 10Read full review |
Pros & cons | Pros
| Pros
|
Summary | When money is but a mild concern, a brand-new Mercedes-Benz is a reasonable purchase. The E-Class is the company's most practical and versatile car, as high-quality and necessary in a nice garage as a Kitchen-Aid mixer is in a baker's kitchen. It offers four body styles, four engines, and dozens of color schemes. Fast or efficient? Loud or library quiet? Modest or rich as hell? The E-Class is all of those things, depending on which of the 13 models you order and how deep into the options list you dive. For 2021, the E-Class receives a mid-cycle update for the infotainment system, engines, and exterior styling. We tested the AMG E53 that features a mild-hybrid inline-six powertrain. | The 2022 Mercedes-Benz S-Class is a full-size four-door luxury sedan with a 48-volt mild hybrid gasoline-electric powertrain, including a turbocharged 3.0-liter inline six-cylinder gas engine (S500) or twin-turbo 4.0-liter V8 (S580), with EQ Boost, a nine-speed automatic transmission, and all-wheel drive (AWD). The S500 starts at $111,100; the S580 starts at $117,700. The EPA estimates the S500 can achieve fuel economy of up to 21 mpg city/30 mpg highway/24 mpg combined, while the S580 is rated at 16 mpg city/25 mpg highway/19 mpg combined. |
Video | No video found | |
Popular Features & Specs | ||
Engine | 2.0L 255 hp I4 | 3.0L 429 hp I6 |
Drive Train | RWD | AWD |
Seating Capacity | 5 | 5 |
Horsepower | 255 hp @ 5800 rpm | 429 hp @ 6100 rpm |
MPG City | 22 | 21 |
MPG Highway | 31 | 30 |
Engine | ||
Engine Name | 2.0L 255 hp I4 | 3.0L 429 hp I6 |
Torque | 273 lb-ft @ 1800 rpm | 384 lb-ft @ 1800 rpm |
Horsepower | 255 hp @ 5800 rpm | 429 hp @ 6100 rpm |
Drivetrain | RWD | AWD |
Fuel Economy | ||
MPG City | 22 | 21 |
MPG Highway | 31 | 30 |
Interior | ||
Leather Seats | Optional | |
Seating Capacity | 5 | 5 |
Key Features | ||
Navigation System | Standard | Optional |
Sunroof/Moonroof | Standard | Optional |
Safety | ||
Front Crash Overall | 5 | |
Side Crash Overall | 5 | |
Dimensions & Capacity | ||
Cargo Space | 13.1 cu ft | 12.9 cu ft |
Curb Weight | 3781 lbs | 4740 lbs |
Height | 57.8 in | 59.2 in |
Length | 194.3 in | 208.2 in |
Width | 81.3 in | 83.0 in |
Wheelbase | 115.7 in | 126.6 in |
Maximum Payload | 1387 lbs | |
Number of doors | 4 | 4 |
The 2021 Mercedes-Benz E-Class, part of the W213 generation, showcased a design evolution that embraced the "sensual purity" theme, moving away from the sharper lines of its predecessor. This model featured a more fluid and curvier form, reminiscent of the 2014 S-Class and 2015 C-Class. The E-Class received updates such as squinted headlights, an inverted trapezoid grille, and horizontal taillights, giving it a slightly edgier appearance. Despite these changes, the E-Class maintained its reputation as a handsome and elegant vehicle, available in sedan, wagon, coupe, and convertible forms. The interior was a luxurious haven, with rich woods, aluminum, and carbon fiber accents, complemented by advanced technology like dual 12-inch screens and a digital instrument panel.
In contrast, the 2022 Mercedes-Benz S-Class continued to impress with its sleek and sophisticated design, following a complete makeover in the previous year. The S-Class retained its flagship status with a long, low profile that exuded elegance. The exterior design was characterized by a proud Mercedes-Benz grille and a star hood ornament, while the interior was a testament to luxury and innovation. The dashboard featured a waterfall of open-pore wood trim and a 12.8-inch touchscreen, with a separate 12.3-inch digital instrument panel. The cabin was adorned with high-quality materials, offering a serene and comfortable environment for both drivers and passengers.
The 2021 Mercedes-Benz E-Class introduced significant changes under the hood, transitioning from conventional V6 engines to electrified inline-six powertrains for its high-volume models. The E450 became a hybrid, utilizing a 48-volt electrical system to supplement the engine with an electric starter-generator, providing brief boosts of up to 21 horsepower and 184 pound-feet of torque. This setup allowed for smoother engine restarts and improved fuel efficiency. The E450's 3.0-liter inline-six engine produced 362 hp and 369 lb-ft of torque, while the AMG E53 added a second turbo, delivering 429 hp and 384 lb-ft of torque. The AMG E63 S, with its hand-built 4.0-liter V8 engine, boasted 603 hp and 627 lb-ft of torque, offering exhilarating performance. Despite its power, the E-Class maintained a comfortable ride, with fuel economy ratings of 26 mpg combined for the E450 and 25 mpg combined for the E350.
The 2022 Mercedes-Benz S-Class offered a refined driving experience with its turbocharged 3.0-liter inline-six-cylinder engine in the S500, producing 429 hp and 384 lb-ft of torque, enhanced by the EQ Boost system. The S580 featured a twin-turbocharged 4.0-liter V8 engine, also benefiting from EQ Boost. Both models utilized a nine-speed automatic transmission and standard 4Matic AWD. The S500 accelerated from 0-60 mph in 4.9 seconds, while the S580 achieved the same in 4.4 seconds. Despite their weight, both models delivered smooth handling and powerful braking. The S500 offered fuel economy ratings of 21 mpg city/30 mpg highway, while the S580 achieved 16 mpg city/25 mpg highway.
The 2021 Mercedes-Benz E-Class featured a redesigned infotainment system with a touchscreen interface, making everyday tasks more intuitive. The cabin was spacious, accommodating four adults comfortably, with ample headroom and legroom. The E-Class offered various body styles, including a sedan with 13 cubic feet of trunk space, a coupe, a convertible, and a wagon with a stowable rear-facing jump seat. The E450 All-Terrain wagon added versatility with increased ground clearance and plastic body cladding. However, some features like rear USB ports and heated rear seats were missing in the E53 model.
The 2022 Mercedes-Benz S-Class excelled in providing a luxurious and comfortable environment for all occupants. The cabin featured powered sun blinds, a Panorama Sunroof, and a 13.8-cubic-foot trunk for ample storage. The front seats offered heating, ventilation, massage functions, and memory settings, while the Executive Line package enhanced rear-seat comfort with multicontour seats and entertainment systems. The S-Class also included six USB-C ports and a 115-volt power supply in the rear. Soft-close doors added convenience, although their wide opening angle could be challenging for some passengers.
The 2021 Mercedes-Benz E-Class was equipped with the MBUX infotainment system, featuring a touchscreen interface and gesture controls. The system offered natural voice processing, live camera feeds for navigation, and optional driving assists. The instrument cluster allowed for customizable displays, providing a modern and interactive experience. However, the system lacked over-the-air updates, and Apple CarPlay and Android Auto were not wireless.
The 2022 Mercedes-Benz S-Class showcased cutting-edge technology with a 12.8-inch OLED touchscreen and a 12.3-inch LED virtual instrument panel. The optional 3D instrument cluster added depth and visual interest, while augmented video for navigation and an available augmented reality head-up display enhanced the driving experience. The standard Burmester 3D Surround sound system provided high-fidelity audio, with an optional 4D system for an immersive experience. The S-Class also featured EQ Boost and rear-axle steering for improved maneuverability.
The 2021 Mercedes-Benz E-Class was recognized for its safety, earning a five-star overall rating from the NHTSA and a "Top Safety Pick+" from the IIHS. It featured innovations like Pre-Safe Sound and side bolster inflation during collisions. Standard safety features included forward automatic emergency braking and blind-spot monitoring, with additional driver-assist features available as options.
The 2022 Mercedes-Benz S-Class prioritized safety with a comprehensive suite of standard and optional features. Magic Vision Control optimized windshield spray, while driver assistance systems included adaptive cruise control, active steering assist, and active brake assist. The S-Class also offered car-to-x communication and rear-passenger airbags for enhanced protection.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz E-Class is 8.3 out of 10, while the 2022 Mercedes-Benz S-Class scores 8.7 out of 10. Based on these ratings, the 2022 Mercedes-Benz S-Class is the recommended choice for those seeking the pinnacle of luxury, technology, and safety in a flagship sedan.
Choose the 2021 Mercedes-Benz E-Class if:
- You prefer a more affordable luxury vehicle with a spacious and elegant interior.
- You value a variety of body styles, including sedan, coupe, convertible, and wagon options.
- You seek a balance between performance and comfort, with advanced technology features.
Choose the 2022 Mercedes-Benz S-Class if:
- You desire the latest in luxury and technology, with a focus on comfort and innovation.
- You prioritize a flagship sedan with a sleek design and a serene cabin environment.
- You require advanced safety features and driver assistance systems for peace of mind.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz E-Class is 8.3 out of 10, while the 2022 Mercedes-Benz S-Class scores 8.7 out of 10. Based on these ratings, the 2022 Mercedes-Benz S-Class is the recommended choice for those seeking the pinnacle of luxury, technology, and safety in a flagship sedan.
Choose the 2021 Mercedes-Benz E-Class if:
Shop Now- You prefer a more affordable luxury vehicle with a spacious and elegant interior.
- You value a variety of body styles, including sedan, coupe, convertible, and wagon options.
- You seek a balance between performance and comfort, with advanced technology features.
Choose the 2022 Mercedes-Benz S-Class if:
Shop Now- You desire the latest in luxury and technology, with a focus on comfort and innovation.
- You prioritize a flagship sedan with a sleek design and a serene cabin environment.
- You require advanced safety features and driver assistance systems for peace of mind.

By: CarGurus + AI
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