Used 2021 Toyota Sienna for Sale nearSaint Louis, MO

How much does the 2021 Toyota Sienna cost?

Prices have softened 3.59% compared to this time last year, making it a favorable time to shop this model year.

There are 1,486 listings available, which gives you a meaningful pool to compare prices and equipment.

Is the 2021 Toyota Sienna a good car?

Generally — the 2021 Toyota Sienna earns a 4.3/5 user rating and an 8.3/10 expert rating. The model scores 9/10 across Look and feel, Form and function, and Technology.

Drivers consistently praise the roomy interior, excellent gas mileage, and smooth handling. The AWD and hybrid combination also comes up as a strong fit for road trips and everyday family use.

The main trade-offs are the lacking stereo and uninspired styling, along with some concerns about acceleration and interior material quality. In practical terms, you’re looking at a minivan that leans hard into efficiency and space rather than flash.

The Sienna’s family-hauling mission is clear in the overview: it’s built for buyers who want a spacious, efficient minivan with a modern hybrid setup. With 36.3% of listings marked as good or great deals, the market gives you some room to shop selectively.

Is the 2021 Toyota Sienna reliable?

Owners rate it 4.3/5, a solid signal of long-term satisfaction.

User feedback points to a dependable, trouble-free ownership experience, with drivers repeatedly highlighting the Sienna’s excellent gas mileage, smooth handling, and overall confidence for road trips. The same feedback also suggests buyers can count on its roomy interior and hybrid setup for everyday family duty.

Toyota describes the hybrid powertrain as a proven setup, which supports the impression of long-term dependability. The ownership picture is still worth checking carefully on a used example, especially if you want to avoid surprises tied to prior use or missing equipment.

What should I look for when buying a used 2021 Toyota Sienna?

At 71.5% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.

You should start with a vehicle history report and then prioritize a thorough pre-purchase inspection. Focus on body condition, signs of prior repair, and whether the cabin and tech features match the trim level you’re considering.

Key things to evaluate:

• Trim level: LE and XLE use 17-inch wheels, while Limited, XSE AWD, and Platinum AWD move to 18-inch wheels, and XSE FWD and Platinum FWD get 20-inch wheels. The cabin and equipment level rise as you move up, and the base trim is the most stripped-down version.
• Powertrain: A 2.5-liter four-cylinder engine and two electric motors produce 243 horsepower. Front-wheel drive is standard, all-wheel drive is available, and the hybrid setup is tuned for smooth, efficient driving rather than quick throttle response.
• Safety package: Toyota Safety Sense 2.0 is standard and includes full-speed range dynamic radar cruise control, lane-tracing assist, pre-collision system with pedestrian and bicyclist detection, lane-departure alert, automatic high beams, and road sign assist. The Star Safety System is also standard.
• Infotainment: A nine-inch touchscreen is standard, along with Apple CarPlay, Android Auto, Amazon Alexa, Bluetooth, and USB ports. Wireless phone integration is not mentioned.
• Fuel efficiency: Front-wheel-drive models are predicted to achieve 36 mpg city, 36 mpg highway, and 36 mpg combined, while all-wheel-drive models are rated at 35 mpg city, 36 mpg highway, and 35 mpg combined.

Which 2021 Toyota Sienna trim should I buy?

The 2021 Toyota Sienna is offered in 5 trim levels: LE, XLE, XSE, Limited, Platinum.

Here's the short version:

• LE: This is the entry point, and it gives you the standard hybrid powertrain, Toyota Safety Sense 2.0, a nine-inch touchscreen, and the core efficiency and space that define the Sienna. It’s the value play if you want the lowest-cost way into the model.
• XLE: This is the best-value trim for many shoppers because it adds more convenience and tech while staying below the higher-priced luxury-oriented versions. It also opens the door to more available equipment, including features that are not standard on LE.
• XSE: This trim adds a more distinctive look and sits in the middle of the lineup with a stronger style focus. It’s a good fit if you want a more expressive Sienna without jumping all the way to the top trims.
• Limited: This is where the Sienna starts to feel more upscale, with more advanced tech and comfort features. It suits you if you want a more premium family hauler.
• Platinum: This is the top trim and brings the most equipment, including the 10-inch head-up display and other high-end tech touches. Choose it if you want the most fully loaded version.

Toyota Safety Sense 2.0 and the Star Safety System are standard across all trim levels.

Is now a good time to buy a used 2021 Toyota Sienna?

This looks like a moderate, selective buyer’s market, so you can shop carefully and still find worthwhile listings.

• Deal availability: 36.3% of listings are priced as good or great deals.
• Inventory: There are 1,486 listings available.
• Price trend: Prices have softened 3.59% compared with last year.
• Clean inventory: 71.5% of listings are accident-free.

If you find a listing below $32,909, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Toyota Sienna's resale value?

The current average of $33,797 sits slightly below last year's $35,055.

That softer pricing suggests the Sienna has become a little easier to buy than it was a year ago, which can help future resale if you purchase at the right number. If you buy near the lower end of the current range, you give yourself a better chance of limiting depreciation later.

Strong demand for efficient, spacious family vehicles can also support used-market interest over time. Vehicles with solid owner satisfaction ratings, like this model year's 4.3/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Toyota Sienna safe?

The 2021 Toyota Sienna comes with Toyota Safety Sense 2.0, which includes full-speed range dynamic radar cruise control, lane-tracing assist, pre-collision system with pedestrian and bicyclist detection, lane-departure alert, automatic high beams, and road sign assist.

It earns a 7/10 safety score from our experts.

That suite is standard on all trim levels, along with the Star Safety System, 10 airbags, LATCH connectors, a rear-seat reminder system, and a tire pressure monitoring system. An inflator kit is standard, and a spare tire remains available.

One caveat for used shoppers is that the 2021 crash-test ratings had not yet been released in the source material, so you should lean more heavily on the standard safety equipment and the vehicle’s condition when evaluating a specific listing.

Should I buy a 2021 Toyota Sienna or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 36.3% of listings are priced as good or great deals.
• At 71.5% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.
• Price trend: Prices have softened 3.59% compared with last year.
• Owners rate it 4.3/5 — a solid satisfaction signal.
• Toyota’s 2021 redesign adds a standard hybrid powertrain and a major makeover.

Consider the 2020 if:

• At $25,997, the 2020 costs less than the current year's $33,797 average.
• It offers all-wheel drive and strong everyday practicality.

Consider the 2022 if:

• At $35,913, the 2022 costs more than the current year's $33,797 average.
• It adds a Woodland trim aimed at buyers who want a more adventurous look.

The bottom line: If you want the redesigned hybrid Sienna and can shop carefully, the 2021 is the sweet spot. If price matters most, the 2020 is the budget-friendly path, while the 2022 makes sense if you want the newer-year carryover with a little extra personality.

How does the 2021 Toyota Sienna compare to the 2021 Chrysler Pacifica?

Expert Pros & Cons (per CarGurus review team)

2021 Toyota Sienna:

• Pros: Fuel-efficient, Great ride quality, Spacious.
• Cons: Stereo is lacking, Uninspired styling.

2021 Chrysler Pacifica:

• Pros: Stylish design, Spacious third row, Impressive technology.
• Cons: Plug-in hybrid can't be ordered with all-wheel drive.

Our experts score the 2021 Toyota Sienna 8.3/10 and the 2021 Chrysler Pacifica 8.7/10. The Sienna leans into fuel efficiency, ride quality, and space, while the Pacifica counters with more style and stronger tech appeal. If you want the more efficient family hauler, the Sienna fits better; if you care more about design and technology, the Pacifica has the edge.

Read our full side-by-side expert comparison here.

These recommendations are based on CarGurus' proprietary market data from November 10, 2026, CarGurus experts' opinions, and generative AI.