Used 2021 Mercedes-Benz E-Class for Sale near Florida
134 results
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray (Selenite Grey Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 31,422
- Stock #:
- MB001619
- VIN:
- W1KZF8EB6MB001619
-$1,000
Sponsored by Mercedes-Benz of Ft. Lauderdale
2021 Mercedes-Benz E-Class
E 350 4MATIC
31,422 mi
$34,999
$33,999
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- MANUFAKTUR Diamond White Metallic
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 13,470
- Stock #:
- I1296
- VIN:
- W1KZF8DB1NB012322
Sponsored Listing
2022 Mercedes-Benz E-Class
E 350 RWD
13,470 mi
$37,942
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 71,520
- Stock #:
- LU1527
- VIN:
- W1KZF8EB2MA983073
Sponsored Listing
2021 Mercedes-Benz E-Class
E 350 4MATIC
71,520 mi
$23,326
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 27,861
- Stock #:
- PB10133
- VIN:
- W1KZF8DB6NB076095
-$990
2022 Mercedes-Benz E-Class
E 350 RWD
27,861 mi
$36,933
$35,943
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Black
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Classic Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 8,100
- Stock #:
- BCY05005A
- VIN:
- WDD1J6HB9LF129307
2020 Mercedes-Benz E-Class
E 450 Coupe RWD
8,100 mi
$40,438
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Polar White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 96,690
- Stock #:
- TLA73076B
- VIN:
- W1KZF6JB0LA806644
-$501
2020 Mercedes-Benz E-Class
E 450 4MATIC AWD
96,690 mi
$23,344
$22,843
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Silver
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,665
- Stock #:
- TLA701153
- VIN:
- WDDZF8DB5LA701153
2020 Mercedes-Benz E-Class
E 350 Sedan RWD
41,665 mi
$25,213
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Iridium Silver Metallic
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 18,761
- Stock #:
- LA802051
- VIN:
- W1KZF6JB8LA802051
2020 Mercedes-Benz E-Class
E 450 4MATIC AWD
18,761 mi
$37,089
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Artico Almond Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 37,271
- Stock #:
- MA952538
- VIN:
- W1KZF5KB4MA952538
2021 Mercedes-Benz E-Class
E 450 4MATIC Sedan AWD
37,271 mi
$35,283
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 37,826
- Stock #:
- 28894607
- VIN:
- W1K1J6JB2LF136660
2020 Mercedes-Benz E-Class
E 450 4MATIC Coupe AWD
37,826 mi
$37,497
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 55,090
- Stock #:
- R927897
- VIN:
- W1KZF8DB8MA927897
2021 Mercedes-Benz E-Class
E 350 RWD
55,090 mi
$27,754
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Diamond White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Oyster Leather
- Transmission:
- 9-Speed Automatic
- Mileage:
- 11,270
- Stock #:
- 123042
- VIN:
- WDD1J6HB2LF123042
-$1,000
2020 Mercedes-Benz E-Class
E 450 Coupe RWD
11,270 mi
$32,704
$31,704
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 22,144
- Stock #:
- P087268
- VIN:
- W1KZF8DB0NB087268
2022 Mercedes-Benz E-Class
E 350 RWD
22,144 mi
$37,900
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 840 currently listed for sale and an average price of $38,392.00, 33.1% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
74.3% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class received a mid-cycle update that includes enhancements to the infotainment system, new engine options, and refined exterior styling, making it more appealing than ever in the luxury sedan market.
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 31,408
- Stock #:
- 28230BB
- VIN:
- W1KZF8DB9NB076706
2022 Mercedes-Benz E-Class
E 350 RWD
31,408 mi
$34,265
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,253
- Stock #:
- NNB072344T
- VIN:
- W1KZF8DB3NB072344
2022 Mercedes-Benz E-Class
E 350 RWD
36,253 mi
$35,186
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- Automatic
- Mileage:
- 8,163
- Stock #:
- NB088162
- VIN:
- W1KZF8DB0NB088162
2022 Mercedes-Benz E-Class
E 350 RWD
8,163 mi
$39,993
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 48,205
- Stock #:
- NB084978
- VIN:
- W1KZF5KB3NB084978
2022 Mercedes-Benz E-Class
E 450 4MATIC Sedan AWD
48,205 mi
$37,598
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Lunar Blue Metallic
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,598
- Stock #:
- LA823037
- VIN:
- W1KZF8DBXLA823037
2020 Mercedes-Benz E-Class
E 350 Sedan RWD
25,598 mi
$25,898
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- MANUFAKTUR Diamond White Metallic
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 13,470
- Stock #:
- I1296
- VIN:
- W1KZF8DB1NB012322
2022 Mercedes-Benz E-Class
E 350 RWD
13,470 mi
$37,942
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black W/red Stitching
- Transmission:
- Automatic
- Mileage:
- 105,320
- Stock #:
- 158911
- VIN:
- W1K1J6BB1LF139483
2020 Mercedes-Benz E-Class
AMG E 53 Coupe 4MATIC
105,320 mi
$27,895
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 12,608
- Stock #:
- RB184672
- VIN:
- W1KZF8DB4NB087824
2022 Mercedes-Benz E-Class
E 350 RWD
12,608 mi
$37,219
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 67,716
- Stock #:
- 9238
- VIN:
- W1KZF6BB3NB013379
2022 Mercedes-Benz E-Class
AMG E 53 Sedan 4MATIC
67,716 mi
$43,378
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Convertible
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Silver
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 9,392
- Stock #:
- 913418
- VIN:
- W1K1K6BB5MF162327
Sponsored Listing
2021 Mercedes-Benz E-Class
AMG E 53 Cabriolet 4MATIC
9,392 mi
$62,196
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall
Summary
With 840 currently listed for sale and an average price of $38,392.00, 33.1% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
74.3% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class received a mid-cycle update that includes enhancements to the infotainment system, new engine options, and refined exterior styling, making it more appealing than ever in the luxury sedan market.
Why it stands out
The 2021 Mercedes-Benz E-Class represents a perfect blend of luxury, performance, and advanced technology. Notable for its multiple powertrain options, including electrified inline-six engines and hybrid variants, it provides both power and efficiency. The cabin boasts exceptional materials and meticulous craftsmanship, ensuring a comfortable and class-leading interior experience. The vehicle's latest infotainment system, MBUX, features intuitive controls and stunning graphics displayed across dual 12-inch screens, enhancing the overall driving experience. Although some advanced safety features are not standard, Mercedes' commitment to safety is evident, with a suite of options available for buyers. Despite its premium price point, which begins at $54,250, the E-Class offers exceptional value, especially as a pre-owned option.
Other model years to consider
- Average price: $23,850.00
- Good/great deal percentage: 35.0%
- User rating: 4.76 / 5
- Total listings: 1,381
- Average price: $30,680.00
- Good/great deal percentage: 34.2%
- User rating: 5 / 5
- Total listings: 991
- Average price: $41,049.00
- Good/great deal percentage: 32.8%
- User rating: 5 / 5
- Total listings: 1,063
This analysis is based on CarGurus' proprietary market data from June 15, 2026, CarGurus experts' opinions, and generative AI.
Relevant articles
The Best Family Sedans of 2026
Advanced safety features that were once exclusive to luxury cars are now standard on many family sedans. And while sedans might not have the space of an SUV or a minivan, they do have efficiency on their side. Here are our top 10.
2026 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Sitting squarely in the midsize luxury sedan segment, the 2026 Mercedes-Benz E-Class competes with the BMW 5 Series, the Audi A6, and the Lexus ES.
2025 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Thoroughly updated last year, the Mercedes-Benz E-Class returns for 2025 with added safety equipment, a new entry-level trim, and an AMG E 53 Hybrid version designed to deliver equal parts performance and efficiency.
4.7 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
Elvis K. N
Reviewed a 2021 Mercedes-Benz E-Class on Jan 29, 2023
Very nice car but does not have active lane keeping assist.
Elvis E
Reviewed a 2021 Mercedes-Benz E 350 RWD on Apr 30, 2023
Best Car Ever! Great gas mileage. No problems so far at all! This is my 2nd Mercedes E-Class and I have no regrets buying it. Has great power. Can go really fast in seconds. If you like sporty exterior and luxury interior then this Mercedes Benz E350 2021 is the car for you!
2021 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| AMG E 53 Coupe 4MATIC | $76,250 |
| E 450 4MATIC Coupe AWD | $67,450 |
| E 450 Cabriolet RWD | $71,950 |
| AMG 53 E Sedan 4MATIC | $73,900 |
| E 450 4MATIC Sedan AWD | $62,000 |
| AMG E 63 S Sedan 4MATIC | $107,500 |
| E 350 4MATIC | $56,750 |
| E 350 RWD | $54,250 |
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
See more price trends
