Used 2021 Mercedes-Benz E-Class for Sale near Detroit, MI
109 results
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 115 currently listed for sale near Detroit, MI and an average price of $69,796.00, 24.3% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
76.5% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update, enhancing the infotainment system, engines, and exterior styling, making it a versatile luxury sedan for various buyer preferences.
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall
Summary
With 115 currently listed for sale near Detroit, MI and an average price of $69,796.00, 24.3% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
76.5% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update, enhancing the infotainment system, engines, and exterior styling, making it a versatile luxury sedan for various buyer preferences.
Why it stands out
The 2021 Mercedes-Benz E-Class continues to be a benchmark in the luxury midsize segment, thanks to its sophisticated blend of performance, comfort, and advanced technology. Notably, it boasts a switch to electrified inline-six powertrains which enhance both performance and efficiency for many of its higher-volume models. The E-Class is available in multiple body styles and configurations, catering to diverse tastes and needs while maintaining its trademark luxurious interior, which features rich materials and cutting-edge tech, including the MBUX infotainment system. With a core focus on comfort, it provides a smooth ride without compromising the thrill of driving—especially noticeable in the AMG variants. Although some buyers have raised concerns about cost and the lack of standard advanced safety features, the E-Class remains a solid choice for those in search of a distinguished vehicle that excels in both daily driving and long journeys.
Other model years to consider
- Average price: $50,000.00
- Good/great deal percentage: 27.5%
- User rating: 5 / 5
- Total listings: 131
- Average price: $21,988.00
- Good/great deal percentage: 22.0%
- User rating: 4.76 / 5
- Total listings: 232
- Average price: $19,064.00
- Good/great deal percentage: 25.1%
- User rating: 4.78 / 5
- Total listings: 203
This analysis is based on CarGurus' proprietary market data from June 2, 2026, CarGurus experts' opinions, and generative AI.
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2026 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Sitting squarely in the midsize luxury sedan segment, the 2026 Mercedes-Benz E-Class competes with the BMW 5 Series, the Audi A6, and the Lexus ES.
2025 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Thoroughly updated last year, the Mercedes-Benz E-Class returns for 2025 with added safety equipment, a new entry-level trim, and an AMG E 53 Hybrid version designed to deliver equal parts performance and efficiency.
4.7 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
Elvis K. N
Reviewed a 2021 Mercedes-Benz E-Class on Jan 29, 2023
Very nice car but does not have active lane keeping assist.
Elvis E
Reviewed a 2021 Mercedes-Benz E 350 RWD on Apr 30, 2023
Best Car Ever! Great gas mileage. No problems so far at all! This is my 2nd Mercedes E-Class and I have no regrets buying it. Has great power. Can go really fast in seconds. If you like sporty exterior and luxury interior then this Mercedes Benz E350 2021 is the car for you!
2021 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| E 450 4MATIC Coupe AWD | $67,450 |
| E 450 Cabriolet RWD | $71,950 |
| AMG E 63 S Wagon 4MATIC | $112,450 |
| E 450 4MATIC Sedan AWD | $62,000 |
| AMG 53 E Sedan 4MATIC | $73,900 |
| AMG E 63 S Sedan 4MATIC | $107,500 |
| E 350 4MATIC | $56,750 |
| E 350 RWD | $54,250 |
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
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