Used 2021 Mercedes-Benz E-Class for Sale near Cleveland, OH
123 results
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 131 currently listed for sale near Cleveland, OH and an average price of $50,920.00, 38.2% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
94.7% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update with a modernized infotainment system, four body styles, and electrified inline-six powertrains for better performance and fuel efficiency.
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall
Summary
With 131 currently listed for sale near Cleveland, OH and an average price of $50,920.00, 38.2% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
94.7% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update with a modernized infotainment system, four body styles, and electrified inline-six powertrains for better performance and fuel efficiency.
Why it stands out
The 2021 Mercedes-Benz E-Class is a remarkable blend of luxury, advanced technology, and performance, making it an appealing choice for buyers seeking a premium midsize sedan. With four different body styles and multiple engine options, the E-Class caters to various preferences, from those desiring efficiency in a 2.0-liter turbo four-cylinder to the thrill of the AMG E53's powerful hybrid inline-six. This year's model benefits from a mid-cycle update, including an enhanced infotainment system, redesigned exterior, and improved engine performance, showcasing Mercedes-Benz's commitment to innovation and luxury. Owners appreciate the car's elegant design, comfortable interior, and impressive technology features, although there are critiques regarding the pricing and the absence of some expected luxury features like active lane keeping assist. Overall, the 2021 E-Class delivers a balanced experience of comfort and sophistication while maintaining impressive safety ratings.
Other model years to consider
- Average price: $29,999.00
- Good/great deal percentage: 45.6%
- User rating: 5 / 5
- Total listings: 136
- Average price: $40,412.00
- Good/great deal percentage: 26.3%
- User rating: 5 / 5
- Total listings: 156
- Average price: $24,890.00
- Good/great deal percentage: 22.4%
- User rating: 4.76 / 5
- Total listings: 241
This analysis is based on CarGurus' proprietary market data from June 2, 2026, CarGurus experts' opinions, and generative AI.
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2026 Mercedes-Benz E-Class Pricing, Specs, and Release Date
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2025 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Thoroughly updated last year, the Mercedes-Benz E-Class returns for 2025 with added safety equipment, a new entry-level trim, and an AMG E 53 Hybrid version designed to deliver equal parts performance and efficiency.
4.7 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
Elvis K. N
Reviewed a 2021 Mercedes-Benz E-Class on Jan 29, 2023
Very nice car but does not have active lane keeping assist.
Elvis E
Reviewed a 2021 Mercedes-Benz E 350 RWD on Apr 30, 2023
Best Car Ever! Great gas mileage. No problems so far at all! This is my 2nd Mercedes E-Class and I have no regrets buying it. Has great power. Can go really fast in seconds. If you like sporty exterior and luxury interior then this Mercedes Benz E350 2021 is the car for you!
2021 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| E 450 4MATIC Coupe AWD | $67,450 |
| E 450 Cabriolet RWD | $71,950 |
| AMG E 63 S Wagon 4MATIC | $112,450 |
| E 450 4MATIC Sedan AWD | $62,000 |
| AMG 53 E Sedan 4MATIC | $73,900 |
| AMG E 63 S Sedan 4MATIC | $107,500 |
| E 350 4MATIC | $56,750 |
| E 350 RWD | $54,250 |
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
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