Used 2021 Mercedes-Benz E-Class for Sale near Cleveland, OH
130 results
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 141 currently listed for sale near Cleveland, OH and an average price of $44,516.00, 31.2% of 2021 Mercedes-Benz E-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
94.3% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a luxurious interior with high-quality materials, advanced tech innovations including a digital cockpit, and multiple powertrain options.
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall
Summary
With 141 currently listed for sale near Cleveland, OH and an average price of $44,516.00, 31.2% of 2021 Mercedes-Benz E-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
94.3% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a luxurious interior with high-quality materials, advanced tech innovations including a digital cockpit, and multiple powertrain options.
Why it stands out
The 2021 Mercedes-Benz E-Class is a standout in the luxury midsize sedan segment, known for its harmonious blend of performance, comfort, and cutting-edge technology. With several engine options, from efficient four-cylinders to powerful inline-sixes, it accommodates a variety of driving preferences. The updated infotainment system enhances usability and offers modern features, while the spacious and elegantly designed interior provides a refined environment for both drivers and passengers. Expert reviews praise its impressive ride quality and extensive safety features, solidifying its status as a top choice among luxury vehicles. Although its high starting price can climb significantly with options, it remains a compelling option for those seeking both luxury and practicality.
Other model years to consider
- Average price: $49,239.00
- Good/great deal percentage: 39.4%
- User rating: 5 / 5
- Total listings: 127
- Average price: $42,797.00
- Good/great deal percentage: 24.3%
- User rating: 5 / 5
- Total listings: 173
- Average price: $43,565.00
- Good/great deal percentage: 41.2%
- User rating: 5 / 5
- Total listings: 97
This analysis is based on CarGurus' proprietary market data from April 14, 2026, CarGurus experts' opinions, and generative AI.
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2026 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Sitting squarely in the midsize luxury sedan segment, the 2026 Mercedes-Benz E-Class competes with the BMW 5 Series, the Audi A6, and the Lexus ES.
2025 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Thoroughly updated last year, the Mercedes-Benz E-Class returns for 2025 with added safety equipment, a new entry-level trim, and an AMG E 53 Hybrid version designed to deliver equal parts performance and efficiency.
4.7 Overall rating
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ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Teddi R
Reviewed a 2021 Mercedes-Benz E-Class on Jun 2, 2024
You cant go wrong with any of the E-class Mercedes! They are bulletproof cars with NO issues.
Anonymous
Reviewed a 2021 Mercedes-Benz E-Class on May 2, 2024
Ive owned many Mercedes over the years but always come back to Model E. Best size, forward technology and usually handsome exterior/interior
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
2021 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| AMG E 53 Cabriolet 4MATIC | $82,850 |
| AMG E 63 S Wagon 4MATIC | $112,450 |
| E 450 4MATIC Coupe AWD | $67,450 |
| E 450 4MATIC Sedan AWD | $62,000 |
| AMG 53 E Sedan 4MATIC | $73,900 |
| AMG E 63 S Sedan 4MATIC | $107,500 |
| E 350 4MATIC | $56,750 |
| E 350 RWD | $54,250 |
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
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