Used 2021 Mercedes-Benz E-Class for Sale near Cleveland, OH
130 results
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 141 currently listed for sale near Cleveland, OH and an average price of $44,516.00, 31.2% of 2021 Mercedes-Benz E-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
94.3% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a luxurious interior with high-quality materials, advanced tech innovations including a digital cockpit, and multiple powertrain options.
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall

Summary
With 141 currently listed for sale near Cleveland, OH and an average price of $44,516.00, 31.2% of 2021 Mercedes-Benz E-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
94.3% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a luxurious interior with high-quality materials, advanced tech innovations including a digital cockpit, and multiple powertrain options.
Why it stands out
The 2021 Mercedes-Benz E-Class is a standout in the luxury midsize sedan segment, known for its harmonious blend of performance, comfort, and cutting-edge technology. With several engine options, from efficient four-cylinders to powerful inline-sixes, it accommodates a variety of driving preferences. The updated infotainment system enhances usability and offers modern features, while the spacious and elegantly designed interior provides a refined environment for both drivers and passengers. Expert reviews praise its impressive ride quality and extensive safety features, solidifying its status as a top choice among luxury vehicles. Although its high starting price can climb significantly with options, it remains a compelling option for those seeking both luxury and practicality.
Other model years to consider
- Average price: $49,239.00
- Good/great deal percentage: 39.4%
- User rating: 5 / 5
- Total listings: 127
- Average price: $42,797.00
- Good/great deal percentage: 24.3%
- User rating: 5 / 5
- Total listings: 173
- Average price: $43,565.00
- Good/great deal percentage: 41.2%
- User rating: 5 / 5
- Total listings: 97
This analysis is based on CarGurus' proprietary market data from April 14, 2026, CarGurus experts' opinions, and generative AI.
Relevant articles

The Best Family Sedans of 2026
Advanced safety features that were once exclusive to luxury cars are now standard on many family sedans. And while sedans might not have the space of an SUV or a minivan, they do have efficiency on their side. Here are our top 10.

2026 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Sitting squarely in the midsize luxury sedan segment, the 2026 Mercedes-Benz E-Class competes with the BMW 5 Series, the Audi A6, and the Lexus ES.

2025 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Thoroughly updated last year, the Mercedes-Benz E-Class returns for 2025 with added safety equipment, a new entry-level trim, and an AMG E 53 Hybrid version designed to deliver equal parts performance and efficiency.
4.7 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Teddi R
Reviewed a 2021 Mercedes-Benz E-Class on Jun 2, 2024
You cant go wrong with any of the E-class Mercedes! They are bulletproof cars with NO issues.
Anonymous
Reviewed a 2021 Mercedes-Benz E-Class on May 2, 2024
Ive owned many Mercedes over the years but always come back to Model E. Best size, forward technology and usually handsome exterior/interior
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
2021 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| AMG E 53 Cabriolet 4MATIC | $82,850 |
| AMG E 63 S Wagon 4MATIC | $112,450 |
| E 450 4MATIC Coupe AWD | $67,450 |
| E 450 4MATIC Sedan AWD | $62,000 |
| AMG 53 E Sedan 4MATIC | $73,900 |
| AMG E 63 S Sedan 4MATIC | $107,500 |
| E 350 4MATIC | $56,750 |
| E 350 RWD | $54,250 |
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
See more price trends






