Used 2022 Mercedes-Benz E-Class for Sale near Cleveland, OH
126 results
CarGurus Analysis:
2022 Mercedes-Benz E-Class
- With 127 currently listed for sale near Cleveland, OH and an average price of $49,239.00, 39.4% of 2022 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
- Favorably reviewed: Owners rated the 2022 Mercedes-Benz E-Class 5 / 5 stars.
- 100.0% of 2022 E-Class models on CarGurus are accident free.
- The 2022 Mercedes-Benz E-Class offers a range of body styles including coupe, convertible, and sedan, featuring a turbocharged four-cylinder engine and advanced safety components.
CarGurus Analysis: 2022 Mercedes-Benz E-Class
overall

Summary
- With 127 currently listed for sale near Cleveland, OH and an average price of $49,239.00, 39.4% of 2022 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
- Favorably reviewed: Owners rated the 2022 Mercedes-Benz E-Class 5 / 5 stars.
- 100.0% of 2022 E-Class models on CarGurus are accident free.
- The 2022 Mercedes-Benz E-Class offers a range of body styles including coupe, convertible, and sedan, featuring a turbocharged four-cylinder engine and advanced safety components.
Why it stands out
The 2022 Mercedes-Benz E-Class stands out in the luxury midsize segment for its exceptional variety of body styles and powerful engine options. While previous iterations faced engine drops due to supply chain issues, the E-Class continues to impress with a robust turbocharged four-cylinder engine and the option for a turbo inline-six. The model blends performance with luxury, offering features like automatic high-beam headlights and USB charging ports as standard. The cabin is a testament to Mercedes' focus on luxury, with top-notch materials, ambient lighting, and a high-resolution MBUX infotainment system that integrates modern technology seamlessly. Additionally, the E-Class boasts an impressive array of safety features, including pre-collision assistance and advanced blind-spot monitoring, ensuring peace of mind for drivers and passengers alike.
Other model years to consider
- Average price: $43,565.00
- Good/great deal percentage: 41.2%
- User rating: 5 / 5
- Total listings: 97
- Average price: $42,797.00
- Good/great deal percentage: 24.3%
- User rating: 5 / 5
- Total listings: 173
- Average price: $17,998.00
- Good/great deal percentage: 19.0%
- User rating: 4.76 / 5
- Total listings: 231
This analysis is based on CarGurus' proprietary market data from April 14, 2026, CarGurus experts' opinions, and generative AI.
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Jim S
Reviewed a 2022 Mercedes-Benz E-Class on Mar 6, 2025
The E-class is the midsize line of Mercedes cars, so it’s fine for all sizes except for very tall and large people. The new inline six cylinder is my favorite engine because it has plenty of power and is fuel efficient. Overall, the quality is here and has been for years.
Anonymous
Reviewed a 2022 Mercedes-Benz E-Class on Jul 12, 2024
Great value. 39K with 14K miles and in great condition with premium package. Took it to the Mercedes dealer for inspection and they said it was in great shape (tires, brakes, belts, filters, oil, fluid level, electronics, and even spark plugs). The interior was in pristine condition and the exterior is just as perfect.
Jim S
Reviewed a 2022 Mercedes-Benz E-Class on Mar 7, 2025
The E-class Mercedes Is the midsize car segment, and is large enough for many people who are not over 6’ 6” or more than 380 pounds in my estimation. Quality is noticed in interior seating and fit and finish. The relatively new Inline six cylinder engine has enough power with above average fuel economy. Other engines are available in four cylinder and eight cylinder variants.
Bill F
Reviewed a 2022 Mercedes-Benz E-Class on Jan 7, 2023
First class, quality material and build! You know maintenance is expensive going into it, but it is what it is.
2022 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| E 450 Cabriolet RWD | $73,250 |
| E 450 4MATIC Coupe AWD | $68,600 |
| AMG E 53 Coupe 4MATIC | $77,600 |
| E 450 Coupe RWD | $66,100 |
| AMG E 53 Sedan 4MATIC | $75,000 |
| E 450 4MATIC Sedan AWD | $62,750 |
| E 350 4MATIC | $57,450 |
| E 350 RWD | $54,950 |
2022 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2022 Mercedes-Benz E-Class prices has changed over time.
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