Used 2022 Mercedes-Benz GLS for Sale nearSan Francisco, CA

How much does the 2022 Mercedes-Benz GLS cost?

Prices have softened 14.25% compared to this time last year, making it a favorable time to shop this model year.

There are 893 listings available, which gives you a meaningful amount of inventory to compare.

If you find a listing below $48,171.38, that's toward the low end of the year-round range and worth acting on quickly.

Is the 2022 Mercedes-Benz GLS a good car?

Yes — you’re looking at a 5/5 user-rated SUV with an expert score of 7.33/10. The standout strength is Look and feel at 9/10.

The 2022 GLS sits at the top of Mercedes’ luxury SUV range, and it’s the brand’s biggest SUV, so you get the three-row size and upscale presence that define the model. It’s also positioned as the SUV equivalent of the S-Class sedan, which fits if you want a flagship-feeling family hauler.

The trade-offs are real: the expert review calls out poor ride quality and poor ergonomic design, and advanced safety features are not standard. Even so, the GLS still brings a stylish design, a powerful engine, and a spacious cabin.

With 35.5% of listings marked as good or great deals, you have some room to shop selectively.

Is the 2022 Mercedes-Benz GLS reliable?

Owners rate it 5/5, a strong signal of long-term satisfaction.

The GLS is described as a solid luxury SUV, and the expert review emphasizes that the six-cylinder powertrain provides more than enough muscle for this big vehicle. The mild-hybrid setup also helps the engine feel smoother and reduces workload on the gasoline engine.

Mercedes’ EQ Boost system adds electric assistance in short bursts, and the starter-motor setup supports a more aggressive start/stop system. The review also notes that the standard air suspension can raise and lower ride height, which adds to everyday versatility.

Mercedes includes a four-year, 50,000-mile basic warranty and a four-year, 50,000-mile powertrain warranty. For used buyers, the main long-term risk is that a large, highly equipped luxury SUV can become expensive if neglected maintenance or worn suspension components show up.

What should I look for when buying a used 2022 Mercedes-Benz GLS?

Accident-free inventory is solid at 87.2% — always verify the vehicle history report.

You should still check the history report carefully, because a clean listing percentage does not replace a proper records review. Prioritize a pre-purchase inspection that focuses on suspension behavior, interior controls, and any signs that the vehicle has been used hard. Since this is a flagship luxury SUV, condition matters a lot more than mileage alone.

Key things to evaluate:

• Trim level: In base GLS 450 form, the look is more subtle and less flashy than some rivals, and the test car’s interior was fairly basic by GLS standards. It still felt luxurious, but it did not have reclining seats.
• Powertrain: The GLS 450 uses a 3.0-liter turbocharged inline six-cylinder engine with a nine-speed automatic and EQ Boost mild-hybrid assistance. It makes 362 horsepower and 369 pound-feet of torque, with an additional 21 hp and 184 lb-ft available in short bursts.
• Safety package: Standard safety features include forward collision warning, automatic emergency braking, a driver-attention monitor, automatic high beams, blind-spot monitoring, a surround-view camera system, Crosswind Assist, parking assist, and Pre Safe. Adaptive cruise control, lane-keep assist, second-row side airbags, and more advanced driver-assistance features cost extra.
• Infotainment: The standard MBUX system includes a 12.3-inch touchscreen, a 12.3-inch digital instrument cluster, Bluetooth, Apple CarPlay/Android Auto connectivity, navigation, SiriusXM satellite radio, and natural-language voice recognition.
• Fuel efficiency: EPA fuel-economy ratings are 20 mpg combined, 18 mpg city, and 24 mpg highway.

Which 2022 Mercedes-Benz GLS trim should I buy?

The 2022 Mercedes-Benz GLS is offered in 1 trim level: GLS 450 4Matic.

Here's the short version:

The GLS 450 4Matic is the only choice for this model year, so your decision is less about trim shopping and more about finding the best-condition example with the right options. It gives you the core GLS experience: three-row luxury, the standard six-cylinder mild-hybrid powertrain, all-wheel drive, air suspension, and the surround-view camera system. It suits you best if you want the flagship GLS without waiting for higher-output variants to return.

Mercedes leaves some important safety features as extras, including adaptive cruise control and lane-keep assist.

Is now a good time to buy a used 2022 Mercedes-Benz GLS?

This looks like a moderate, selective buyer’s market, so you can shop carefully without expecting every listing to be a bargain.

• Deal availability: 35.5% of listings are priced as good or great deals.
• Inventory: There are 893 listings available.
• Price trend: Prices have softened 14.25% compared with last year.
• Clean inventory: 87.2% of listings are accident-free.

If you find a listing below $48,171.38, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz GLS's resale value?

The current average of $48,156 sits slightly below last year's $56,156.

That drop suggests the market has already adjusted downward, which can help you buy at a more favorable point in the cycle. For a future seller, it also means you should expect resale value to depend heavily on condition, mileage, and equipment rather than on model-year freshness alone.

Because this is a flagship luxury SUV, well-kept examples should still attract attention from shoppers who want space and prestige in one package. Strong maintenance records and clean history will matter a lot if you want to protect value later.

Vehicles with strong owner satisfaction ratings, like this model year's 5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz GLS safe?

It earns a 6/10 safety score from our experts.

Standard safety features include forward collision warning, automatic emergency braking, a driver-attention monitor, automatic high beams, blind-spot monitoring, a surround-view camera system, Crosswind Assist, parking assist, and Pre Safe. Mercedes also includes a feature that emits “pink noise” to help protect ears during a collision.

You should note that adaptive cruise control, lane-keep assist, second-row side airbags, and several more advanced driver-assistance features are extra-cost items. That means the GLS gives you a strong standard safety base, but not the full suite you might expect on a flagship SUV.

Should I buy a 2022 Mercedes-Benz GLS or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 35.5% of listings are priced as good or great deals.
• Accident-free inventory is solid at 87.2% — always verify the vehicle history report.
• Price trend: Prices have softened 14.25% compared with last year.
• Owners rate it 5/5 — a strong satisfaction signal.
• The 2022 stands out because Mercedes withdrew most V8 models, leaving the GLS 450 as the only version available.

Consider the 2021 if:

• At $48,263, the 2021 costs more than the current year's $48,156 average.
• It emphasizes comfort and refinement with three-row practicality.

The bottom line: If you want the current-year GLS at a lower average price and with a softer market, the 2022 is the cleaner buy. If you’re price-sensitive, the 2021 does not offer a pricing advantage here, so you’re better off focusing on condition, options, and history rather than stepping back a year.

These recommendations are based on CarGurus' proprietary market data from September 4, 2026, CarGurus experts' opinions, and generative AI.