Used 2021 Toyota Sequoia for Sale nearSaint Louis, MO

How much does the 2021 Toyota Sequoia cost?

Prices are up 2.22% year-over-year — a sign of continued demand for this model year.

There are 150 listings available, which suggests a relatively limited pool of used examples.

Is the 2021 Toyota Sequoia a good car?

Generally — the 2021 Toyota Sequoia earns 4.4/5 from owners and 7/10 from our experts. The standout strength is Form and function at 9/10.

Owners consistently point to practicality, good looks, reliable performance, a smooth ride, and ample features. That lines up with the Sequoia’s use case as a roomy, truck-like SUV for you if you value utility and everyday usability over a more carlike feel. The main trade-offs are poor fuel economy and poor value for money, and the older design shows in the dated feel of the cabin and tech. Even so, the market still shows 37.3% good or great deals, which gives you some room to shop carefully.

Is the 2021 Toyota Sequoia reliable?

Owners rate it 4.4/5, a solid signal of long-term satisfaction.

Owner feedback highlights reliable performance, and the model’s age is framed as part of its durability story, with long-term dependability tied to Toyota’s tried-and-true approach. The Sequoia’s straightforward, easy-to-use hardware also supports the sense that it’s built for long-term ownership rather than constant novelty. For used buyers, the main risk is that an older, high-use SUV can hide wear, so condition and maintenance history matter a lot.

What should I look for when buying a used 2021 Toyota Sequoia?

At 69.3% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.

You should start with a vehicle history report and then prioritize a pre-purchase inspection, especially on a truck-based SUV that may have seen family-hauling or towing duty. Focus on overall condition, signs of wear, and whether the vehicle has been maintained consistently. Because used examples can be limited and expensive, it’s worth being selective about mileage, cosmetic condition, and service records.

Key things to evaluate:

• Trim level: The SR5 includes 18-inch alloy wheels, LED fog lights, three-zone climate control, pushbutton start, remote keyless entry, a 7-inch touchscreen, a power moonroof, and a power-adjustable driver’s seat. The SR5 Premium Package adds a power-folding/reclining third row, power-adjustable front passenger seat, leather upholstery, and heated front seats. The TRD Sport adds unique 20-inch wheels, chrome accents, Satin-black TRD logos, TRD floor mats, Bilstein shocks, and a TRD sport-tuned suspension. The Limited adds leather upholstery, heated front seats, auto-dimming power side mirrors, a power liftgate, navigation, and a 12-speaker premium audio system. The Nightshade Edition adds black 20-inch wheels, black leather upholstery, second-row captain’s chairs, and LED fog lights with dark chrome surrounds. The TRD Pro adds off-road-focused hardware, and the Platinum adds heated-and-ventilated front seats, heated second-row captain’s chairs, a larger 9-inch touchscreen, a power-adjustable steering wheel, and air suspension.
• Powertrain: Every trim uses a 5.7-liter V8 with 381 horsepower and 401 pound-feet of torque, paired with a six-speed automatic. Rear-wheel drive is standard, and four-wheel drive is available. It delivers stout acceleration, but the setup is also tied to poor fuel economy.
• Safety package: Toyota Safety Sense-P includes forward-collision warning, automatic emergency braking, pedestrian detection, adaptive cruise control, lane-departure warning, and automatic high beams. It also includes blind-spot monitoring, rear cross-traffic alert, and front-and-rear parking sensors. There are no optional safety features, but you do not get lane-keeping assist or lane-tracing assist.
• Infotainment: The standard system uses a 7-inch touchscreen with Apple CarPlay, Android Auto, Amazon Alexa, and a WiFi hotspot. A 9-inch screen is available on some versions, and the system is described as easy to use with physical buttons.
• Fuel efficiency: EPA-estimated fuel economy is 13 mpg city, 17 mpg highway, and 15 mpg combined for rear-wheel drive. Four-wheel drive keeps the same city and highway figures and returns 14 mpg combined.

Which 2021 Toyota Sequoia trim should I buy?

The 2021 Toyota Sequoia is offered in 6 trim levels: SR5, TRD Sport, Limited, Nightshade Edition, TRD Pro, and Platinum.

Here's the short version:

• SR5: This is the value-focused starting point, and it already gives you the core Sequoia experience: V8 power, a 7-inch touchscreen, three-zone climate control, and a power moonroof. If you want the lowest entry point into the lineup and can live without the extra comfort and convenience upgrades, this is the trim to start with.
• TRD Sport: This trim adds a sportier look and a firmer-feeling chassis tune with Bilstein shocks and a TRD sport-tuned suspension. It makes sense if you want a more distinctive appearance and a slightly more tailored driving feel without jumping all the way to the luxury-oriented trims.
• Limited: This is the best-value choice for many shoppers because it adds leather upholstery, heated front seats, navigation, a power liftgate, and a 12-speaker premium audio system. It gives you a more upscale daily experience without moving into the highest-priced versions.
• Nightshade Edition: This trim is mainly about style, with blacked-out exterior details, black leather upholstery, and second-row captain’s chairs. It suits you if appearance and a more premium cabin presentation matter more than maximizing value.
• TRD Pro: This is the off-road-focused trim, with Fox Racing shocks, a TRD-tuned suspension, skid plates, a limited-slip center differential, and specialized wheels and fog lights. Choose it if you want the most rugged setup in the lineup.
• Platinum: This is the most comfort-oriented trim, adding heated-and-ventilated front seats, heated second-row captain’s chairs, a larger touchscreen, a power-adjustable steering wheel, and air suspension. It’s the pick if you want the most upscale Sequoia experience.

The safety suite is standard across the lineup, so you do not need to move up a trim just to get the core driver-assistance features.

Is now a good time to buy a used 2021 Toyota Sequoia?

This looks like a moderate, selective buyer’s market, so you should shop carefully and compare listings rather than rush.

• Deal availability: 37.3% of listings are priced as good or great deals.
• Inventory: There are 150 listings available.
• Price trend: Prices are up 2.22% year-over-year.
• Clean inventory: 69.3% of listings are accident-free.

If you find a listing below $47,336, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Toyota Sequoia's resale value?

The current average of $48,390 sits slightly above last year's $47,336.

That upward move suggests the market has remained willing to pay for this model year, even with its age and fuel-economy drawbacks. For a future seller, that means well-kept examples can still attract attention if they present cleanly and have strong service history. The limited inventory also helps support pricing, especially for trims and configurations that are harder to find.

Vehicles with solid owner satisfaction ratings, like this model year's 4.4/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Toyota Sequoia safe?

The 2021 Toyota Sequoia earns four-star ratings in the NHTSA rollover test.

It earns a 5/10 safety score from our experts.

Toyota Safety Sense-P includes forward-collision warning, automatic emergency braking, pedestrian detection, adaptive cruise control, lane-departure warning, and automatic high beams. It also comes standard with blind-spot monitoring, rear cross-traffic alert, and front-and-rear parking sensors. There are no optional safety features, but you do not get lane-keeping assist or lane-tracing assist. The main caveat is that the vehicle rides on an older platform and has not been rated in further NHTSA crash tests.

Should I buy a 2021 Toyota Sequoia or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 37.3% of listings are priced as good or great deals.
• At 69.3% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.
• Price trend: Prices are up 2.22% year-over-year.
• Owners rate it 4.4/5 — a solid satisfaction signal.
• It combines standard V8 power with a full suite of driver-assistance features and a roomy, truck-like layout.

Consider the 2022 if:

• It adds a newer redesign with a more modern full-size SUV formula.

The bottom line: If you want the older Sequoia’s straightforward V8 power, roomy cabin, and proven character, the 2021 is the better value to target. If you’re price-sensitive, keep an eye on lower-mileage 2021 listings and compare them against the next model year only if the newer truck’s added freshness is worth the premium to you.

How does the 2021 Toyota Sequoia compare to the 2021 Ford Expedition?

Expert Pros & Cons (per CarGurus review team)

2021 Toyota Sequoia:

• Pros: Powerful engine, Comfortable, Easy-to-use technology.
• Cons: Poor fuel economy, Poor handling, Poor value for money.

2021 Ford Expedition:

• Pros: Comfortable, Spacious, Powerful engine.
• Cons: Advanced safety features are not standard, Poor fuel economy.

Our experts score the 2021 Toyota Sequoia 7/10 and the 2021 Ford Expedition 7/10. The Sequoia leans into simplicity and easy-to-use technology, while the Expedition emphasizes space and comfort. Both have poor fuel economy, but the Expedition offers a more spacious package and stronger used-price value in the table below. If you want the more straightforward, truck-like SUV, the Sequoia fits that brief; if you want more room and a lower average used price, the Expedition is the easier value play.

Read our full side-by-side expert comparison here.

These recommendations are based on CarGurus' proprietary market data from November 3, 2026, CarGurus experts' opinions, and generative AI.