Used 2021 Mercedes-Benz S-Class for Sale near Cincinnati, OH
181 results
![[799] MANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz S-Class S 580 4MATIC AWD Sedan All-Wheel Drive Automatic](https://static.cargurus.com/images/forsale/2026/04/18/14/01/2022_mercedes-benz_s-class-pic-974518954080127668-1024x768.jpeg?io=true&width=640&height=480&fit=bounds&format=jpg&auto=webp)
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 188 currently listed for sale near Cincinnati, OH and an average price of $62,693.00, 23.9% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
79.8% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class introduces advanced technology features, including a cutting-edge infotainment system and a choice of powerful engines, enhancing its luxurious appeal.
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 188 currently listed for sale near Cincinnati, OH and an average price of $62,693.00, 23.9% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
79.8% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class introduces advanced technology features, including a cutting-edge infotainment system and a choice of powerful engines, enhancing its luxurious appeal.
Why it stands out
The 2021 Mercedes-Benz S-Class represents the pinnacle of luxury sedans, combining advanced technology with impressive performance. This model differentiates itself with its twin powertrain options, including a turbocharged inline-six engine producing 429 horsepower in the S500 and a twin-turbo V8 engine generating 496 horsepower in the S580, both featuring a sophisticated all-wheel-drive system. The updated interior boasts a minimalist design focused around a large touchscreen and a digital instrument cluster, providing a modern aesthetic that doesn't compromise comfort. Additionally, the S-Class is outfitted with numerous luxury features such as power-adjustable seats with heating and massage functions, ambient lighting, and an impressive Burmester audio system. While its price may be high, buyers are drawn to its blend of opulence and technology, making it an enduring favorite in the luxury sedan market.
Other model years to consider
- Average price: $69,926.00
- Good/great deal percentage: 23.8%
- User rating: 4.5 / 5
- Total listings: 252
- Average price: $23,330.00
- Good/great deal percentage: 20.6%
- User rating: 5 / 5
- Total listings: 223
- Average price: $23,897.00
- Good/great deal percentage: 23.6%
- User rating: 4.9 / 5
- Total listings: 191
This analysis is based on CarGurus' proprietary market data from April 21, 2026, CarGurus experts' opinions, and generative AI.
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Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
See more price trends
