Used 2022 Mercedes-Benz S-Class for Sale nearCincinnati, OH

Compare 2022 Mercedes-Benz S-Class Trims

The S-Class lineup offers a range of luxury options, from the value-focused S 500 to the high-performance Maybach trims, all featuring AWD.

• Starting at $52,859
• Best MPG/MPGe: 21 city / 30 hwy
• Most Popular: S 580 4MATIC AWD

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

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Trim Deep Dives

S 500 4MATIC AWD — "Who It's For"

The S 500 is the pick for shoppers who want luxury features without the higher price of the S 580. It's the most accessible entry point in the lineup.

• Avg. market price: $52,859 (updated weekly)
• MPG/MPGe: 21 city / 30 hwy
• Inventory: 296 listings
• View S 500 4MATIC AWD listings

S 580 4MATIC AWD — "Who It's For"

The S 580 is the pick for shoppers who want a blend of luxury and performance without stepping up to the Maybach. It's also the most popular trim in the lineup.

• Avg. market price: $63,581 (updated weekly)
• MPG/MPGe: 16 city / 25 hwy
• Inventory: 539 listings
• View S 580 4MATIC AWD listings

Maybach S 580 4MATIC AWD — "Who It's For"

The Maybach S 580 is the pick for shoppers who want top-tier luxury without going for the highest price. It offers exclusivity and advanced features.

• Avg. market price: $125,626 (updated weekly)
• MPG/MPGe: 15 city / 24 hwy
• Inventory: 39 listings — lower availability; may limit negotiating room
• View Maybach S 580 4MATIC AWD listings

Maybach S 680 4MATIC AWD — "Who It's For"

The Maybach S 680 is the pick for shoppers who want the ultimate luxury experience with high performance. It's the most exclusive trim in the lineup.

• Avg. market price: $140,495 (updated weekly)
• MPG/MPGe: 12 city / 21 hwy
• Inventory: 36 listings — lower availability; may limit negotiating room
• View Maybach S 680 4MATIC AWD listings

Trim Recommendations

Most Popular — S 580 4MATIC AWD

With 539 active listings, the S 580 4MATIC AWD is the clear volume leader in the lineup.

Browse S 580 4MATIC AWD listings

Best Budget Option — S 500 4MATIC AWD

At $52,859 avg market price — below the lineup median of $94,603 — it's the most accessible entry point.

Browse S 500 4MATIC AWD listings

Best for Fuel Economy — S 500 4MATIC AWD

With 21/30 MPG/MPGe, the S 500 4MATIC AWD offers the best fuel efficiency in the lineup.

Browse S 500 4MATIC AWD listings

These recommendations are based on CarGurus' proprietary market data from November 12, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2022 Mercedes-Benz S-Class cost?

Prices have softened 11.09% compared to this time last year, making it a favorable time to shop this model year.

There are 1,109 listings available, which gives you a solid amount of inventory to compare.

Is the 2022 Mercedes-Benz S-Class a good car?

Yes — the 2022 Mercedes-Benz S-Class earns a 4.5/5 user rating and an 8.7/10 expert rating. The model scores 9/10 across Look and feel, Form and function, Technology, and Safety.

It fits the full-size luxury sedan brief well: you get a flagship cabin, premium materials, and a smooth, long-distance-friendly ride. The powertrain lineup also gives you serious performance, with a mild-hybrid inline-six or V8 setup and standard all-wheel drive.

The main trade-offs are clear: the design may not appeal to everyone, and the price is high. Even so, the S-Class remains a strong choice if you want executive-level comfort, advanced tech, and a polished driving experience.

Good and great deals account for 34.5% of listings, so there are still worthwhile opportunities if you shop carefully.

Is the 2022 Mercedes-Benz S-Class reliable?

Owners rate it 4.5/5, a strong signal of long-term satisfaction.

The S-Class is built around a sophisticated mild-hybrid setup, and the expert review highlights a smooth, seamless power delivery from the EQ Boost system. It also emphasizes the car’s refined road manners and strong braking, which support the impression of a well-engineered luxury sedan.

Mercedes also backs the car with a broad set of driver-assistance and collision-prep systems, which can help reduce stress in daily use. For used buyers, the main long-term ownership risk is that a highly complex flagship sedan can be expensive to maintain if prior care has been inconsistent.

What should I look for when buying a used 2022 Mercedes-Benz S-Class?

Accident-free inventory is solid at 85% — always verify the vehicle history report.

You should still check the vehicle history report carefully and prioritize a pre-purchase inspection, especially on a car with this much technology and equipment. Focus on overall condition, signs of prior bodywork, and whether the cabin electronics, driver-assistance features, and luxury amenities all work as intended.

Key things to evaluate:

• Trim level: The S500 and S580 are the core trims, and the S500 starts lower while the S580 adds the V8. The cabin is richly appointed either way, but the base setup still gives you the flagship look and feel.
• Powertrain: You can choose between a turbocharged 3.0-liter inline-six mild-hybrid setup and a twin-turbo 4.0-liter V8, both with EQ Boost, a nine-speed automatic transmission, and standard 4Matic AWD. The six-cylinder delivers up to 21 mpg city/30 mpg highway/24 mpg combined, while the V8 is rated at 16 mpg city/25 mpg highway/19 mpg combined.
• Safety package: Standard and available driver-assistance features include active distance assist Distronic, active stop-and-go assist, active steering assist, active emergency stop assist, active lane-change assistant, active brake assist, active speed limit assist, active blind-spot assist, active lane-keeping assist, active parking assist with Parktronic, Pre-Safe Plus with Pre-Safe Sound, Pre-Safe Impulse Side, and car-to-x communication. Rear-passenger airbags and a rear-seat belt bag are available.
• Infotainment: The cabin centers on a 12.8-inch OLED touchscreen with the MBUX system, plus a 12.3-inch digital instrument panel. Wireless smartphone integration and OTA capability are not stated here, so you should verify those features on the exact vehicle you’re considering.
• Fuel efficiency: The S500 can achieve up to 21 mpg city/30 mpg highway/24 mpg combined, while the S580 is rated at 16 mpg city/25 mpg highway/19 mpg combined.

Which 2022 Mercedes-Benz S-Class trim should I buy?

The 2022 Mercedes-Benz S-Class is offered in 4 trim levels: S500 4Matic Luxury Line, S500 4Matic AMG Line, S580 4Matic Luxury Line, S580 4Matic AMG Line.

Here's the short version:

• S500 4Matic Luxury Line: This is the best-value starting point if you want the flagship experience without pushing into the highest price bands. You still get the core S-Class strengths: a refined mild-hybrid inline-six, standard AWD, a 12.8-inch OLED touchscreen, and the full luxury-sedan atmosphere.
• S500 4Matic AMG Line: Choose this if you want the same six-cylinder powertrain but prefer a sportier appearance and a more aggressive presentation. It makes sense if style matters to you as much as comfort.
• S580 4Matic Luxury Line: Step up here if you want the V8 and the stronger performance that comes with it, while keeping the more traditional luxury focus. This is the right pick if effortless power matters most.
• S580 4Matic AMG Line: This is the most expressive version in the lineup, pairing the V8 with the sportier AMG treatment. It suits you if you want maximum presence and performance-oriented styling.

The S-Class includes a wide range of standard and available safety and driver-assistance features, so even the lower trims are well equipped.

Is now a good time to buy a used 2022 Mercedes-Benz S-Class?

This looks like a moderate, selective buyer’s market, so you can shop with some leverage if you stay disciplined.

• Deal availability: 34.5% of listings are priced as good or great deals.
• Inventory: There are 1,109 listings available.
• Price trend: Prices have softened 11.09% compared with last year.
• Clean inventory: 85.0% of listings are accident-free.

If you find a listing below $61,464, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz S-Class's resale value?

The current average of $61,464 sits slightly below last year's $69,128.

That decline suggests the market has already adjusted downward, which can help you as a buyer today but may temper resale upside if you sell soon. For a future seller, the key question is whether the car’s condition and equipment help it stand out from other used examples.

Because the S-Class is a flagship luxury sedan with strong appeal, well-kept examples should still attract interest from shoppers who want comfort, technology, and prestige. Vehicles with strong owner satisfaction ratings, like this model year's 4.5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz S-Class safe?

The 2022 Mercedes-Benz S-Class earns a 9/10 safety score from our experts.

Mercedes equips the S-Class with a long list of standard and available driver-assistance systems, including adaptive cruise control, lane-centering support, automatic emergency braking, blind-spot monitoring, lane-keeping assist, parking assist, and collision-prep features. It also includes car-to-x communication and Pre-Safe systems that prepare the car for certain unavoidable impacts.

The safety package is especially comprehensive for a luxury sedan, and rear-seat protection features are available for executive-style use. That said, you should confirm exactly which assistance features are fitted on the specific car you’re considering, since some equipment varies by trim and option package.

Should I buy a 2022 Mercedes-Benz S-Class or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 34.5% of listings are priced as good or great deals.
• Accident-free inventory is solid at 85% — always verify the vehicle history report.
• Price trend: Prices have softened 11.09% compared with last year.
• Owners rate it 4.5/5 — a strong satisfaction signal.
• It combines a flagship cabin, strong tech, and a refined mild-hybrid powertrain.

Consider the 2021 if:

• At $58,069, the 2021 costs less than the current year's $61,464 average.
• It launched a major redesign with new tech and powertrains.

Consider the 2023 if:

• At $76,332, the 2023 costs more than the current year's $61,464 average.
• It adds a plug-in hybrid option for more electrified driving.

The bottom line: If you want the best balance of price, inventory, and flagship luxury, the 2022 is the smart default. If your budget is tighter, the 2021 can save you money while still delivering the redesigned S-Class experience.

How does the 2022 Mercedes-Benz S-Class compare to the 2022 BMW 7 Series?

These recommendations are based on CarGurus' proprietary market data from November 10, 2026, CarGurus experts' opinions, and generative AI.