Used 2022 Mercedes-Benz S-Class for Sale nearCincinnati, OH

Compare 2022 Mercedes-Benz S-Class Trims

The S-Class lineup offers a range of luxury options, from the value-focused S 500 to the high-performance Maybach trims, all featuring AWD.

• Starting at $56,213
• Best MPG/MPGe: 21 city / 30 hwy
• Most Popular: S 580 4MATIC AWD

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

Missing data displayed as "—".

Trim Deep Dives

S 500 4MATIC AWD — "Who It's For"

The S 500 is the pick for shoppers who want luxury features without the higher price of the S 580. It's the most accessible entry point in the lineup.

• Avg. market price: $56,213 (updated weekly)
• MPG/MPGe: 21 city / 30 hwy
• Inventory: 318 listings
• View S 500 4MATIC AWD listings

S 580 4MATIC AWD — "Who It's For"

The S 580 is the pick for shoppers who want a powerful engine and advanced features without stepping up to the Maybach. It's also the most popular trim in the lineup.

• Avg. market price: $66,362 (updated weekly)
• MPG/MPGe: 16 city / 25 hwy
• Inventory: 550 listings
• View S 580 4MATIC AWD listings

Maybach S 580 4MATIC AWD — "Who It's For"

The Maybach S 580 is the pick for shoppers who want unparalleled luxury and comfort without going for the top-tier Maybach S 680.

• Avg. market price: $126,191 (updated weekly)
• MPG/MPGe: 15 city / 24 hwy
• Inventory: 42 listings — lower availability; may limit negotiating room
• View Maybach S 580 4MATIC AWD listings

Maybach S 680 4MATIC AWD — "Who It's For"

The Maybach S 680 is the pick for shoppers who want the ultimate in luxury and performance, featuring a powerful V12 engine and top-tier amenities.

• Avg. market price: $138,990 (updated weekly)
• MPG/MPGe: 12 city / 21 hwy
• Inventory: 36 listings — lower availability; may limit negotiating room
• View Maybach S 680 4MATIC AWD listings

Trim Recommendations

Most Popular — S 580 4MATIC AWD

With 550 active listings, the S 580 4MATIC AWD is the clear volume leader in the lineup.

Browse S 580 4MATIC AWD listings

Best Budget Option — S 500 4MATIC AWD

At $56,213 avg market price — below the lineup median of $96,276 — it's the most accessible entry point.

Browse S 500 4MATIC AWD listings

Best for Fuel Economy — S 500 4MATIC AWD

With an impressive MPG/MPGe of 21/30, the S 500 is the most fuel-efficient option in the lineup.

Browse S 500 4MATIC AWD listings

These recommendations are based on CarGurus' proprietary market data from September 24, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2022 Mercedes-Benz S-Class cost?

Prices have softened 10.77% compared to this time last year, making it a favorable time to shop this model year.

There are 1,143 listings available, which suggests you have a meaningful amount of inventory to compare.

Is the 2022 Mercedes-Benz S-Class a good car?

Yes — the 2022 Mercedes-Benz S-Class earns a 4.5/5 user rating and an 8.67/10 expert rating. The model scores 9/10 across Look and feel, Form and function, Technology, and Safety.

It fits the full-size luxury sedan brief well: you get a polished, upscale cabin, a stylish design, and a ride quality that supports relaxed executive-style driving. The S-Class also brings strong tech and a flagship feel, with a 12.8-inch OLED touchscreen, a 12.3-inch digital instrument panel, and standard Burmester 3D Surround sound.

The trade-offs are clear: the design may not appeal to everyone, and the price is high. Even so, the car’s combination of comfort, materials, and advanced features makes it a strong fit if you want a luxury sedan that feels substantial and modern.

32.6% of listings are priced as good or great deals, which gives you some room to shop selectively.

Is the 2022 Mercedes-Benz S-Class reliable?

Owners rate it 4.5/5, a strong signal of long-term satisfaction.

The S-Class is built around a refined mild-hybrid setup, and the powertrain is described as seamless, quick, and smooth in everyday use. Its standard all-wheel drive, nine-speed automatic transmission, and strong braking and handling balance support the impression of a well-engineered flagship.

The cabin and chassis also point to durability-minded luxury ownership: Mercedes emphasizes high-quality materials, careful assembly, and advanced systems that are designed to work together without feeling fussy. The maintenance and ownership experience is still tied to a high-end luxury sedan, though, so long-term costs can remain elevated even when the car itself feels robust.

What should I look for when buying a used 2022 Mercedes-Benz S-Class?

Accident-free inventory is solid at 86.3% — always verify the vehicle history report.

You should still check the history report carefully, because a clean listing percentage does not replace a full records review. Prioritize a pre-purchase inspection that focuses on electronics, suspension behavior, and the condition of luxury interior materials, since those are the areas where a flagship sedan can show wear. It also makes sense to confirm that all advanced driver-assistance and infotainment functions operate correctly.

Key things to evaluate:

• Trim level: The S500 4Matic starts at $111,100 in Luxury Line and $115,400 in AMG Line, while the S580 4Matic starts at $117,700 in Luxury Line, $122,000 in AMG Line, and $129,100 in Executive Line. The Luxury Line is the entry point, while the AMG Line adds a sportier appearance and the Executive Line sits at the top of the range.
• Powertrain: The S500 uses a turbocharged 3.0-liter inline-six-cylinder mild-hybrid setup, while the S580 uses a twin-turbo 4.0-liter V8. Both use EQ Boost, a nine-speed automatic transmission, and standard 4Matic all-wheel drive.
• Safety package: Standard driver-assistance features include active distance assist Distronic, active stop-and-go assist, active steering assist with active emergency stop assist and active lane-change assistant, active brake assist with cross-traffic and turn-off functions, active speed limit assist with traffic sign assist, active blind-spot assist with exit warning, active lane-keeping assist, active parking assist with Parktronic, Pre-Safe Plus with Pre-Safe Sound, Pre-Safe Impulse Side, and car-to-x communication. Available rear-passenger airbags and a rear-seat belt bag are also offered.
• Infotainment: The cabin centers on a 12.8-inch OLED touchscreen with the MBUX infotainment system, paired with a 12.3-inch digital instrument panel. The system also includes standard augmented video for navigation, with an available augmented reality head-up display.
• Fuel efficiency: The S500 is rated at up to 21 mpg city, 30 mpg highway, and 24 mpg combined, while the S580 is rated at 16 mpg city, 25 mpg highway, and 19 mpg combined.

Which 2022 Mercedes-Benz S-Class trim should I buy?

The 2022 Mercedes-Benz S-Class is offered in 5 trim levels: S500 4Matic Luxury Line, S500 4Matic AMG Line, S580 4Matic Luxury Line, S580 4Matic AMG Line, S580 4Matic Executive Line.

Here's the short version:

• S500 4Matic Luxury Line: This is the most accessible way into the S-Class, and it gives you the core flagship experience with the six-cylinder mild-hybrid powertrain, standard all-wheel drive, and the full luxury-sedan mission. It makes the most sense if you want the S-Class nameplate and major tech without stretching to the higher-priced trims.
• S500 4Matic AMG Line: This trim keeps the S500 powertrain but adds a more aggressive appearance and a higher starting price. Choose it if you want the entry powertrain but prefer a sportier look.
• S580 4Matic Luxury Line: This is the step up if you want the V8 and the strongest straight-line performance in the standard lineup. It suits you if refinement and power matter more than keeping the price down.
• S580 4Matic AMG Line: This combines the V8 with the sportier AMG Line treatment. It is for buyers who want the stronger engine and a more assertive presentation.
• S580 4Matic Executive Line: This is the top trim listed here, and it is the one to consider if you want the most upscale version of the standard S-Class lineup. It is the best fit when rear-seat presence and maximum prestige matter most.

The safety package is extensive across the lineup, with available rear-passenger airbags and a rear-seat belt bag for added executive-level protection.

Is now a good time to buy a used 2022 Mercedes-Benz S-Class?

This is a moderate market for selective buyers, so you can shop carefully and still find worthwhile listings.

• Deal availability: 32.6% of listings are priced as good or great deals.
• Inventory: There are 1,143 listings available.
• Price trend: Prices have softened 10.77% compared with last year.
• Clean inventory: 86.3% of listings are accident-free.

If you find a listing below $63,166, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz S-Class's resale value?

The current average of $63,247 sits slightly below last year's $70,883.

That price movement suggests the market has already adjusted downward, which can help you buy more confidently now. For a future seller, it also means resale value may depend heavily on condition, mileage, and trim desirability rather than broad market appreciation. Well-kept examples with strong equipment and clean history should hold up better than average.

Vehicles with strong owner satisfaction ratings, like this model year's 4.5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz S-Class safe?

The 2022 Mercedes-Benz S-Class earns a 9/10 safety score from our experts.

Mercedes equips it with a long list of standard driver-assistance features, including adaptive cruise control, lane-centering support, blind-spot monitoring, lane-keeping assist, automatic emergency braking with cross-traffic and turn-off functions, parking assistance, traffic sign recognition, and pre-collision preparation systems. It also includes car-to-x communication and Magic Vision Control, which helps optimize windshield spray delivery.

The safety setup is especially comprehensive for a luxury sedan, and the available rear-seat protection features reinforce its executive focus. The main caveat is that some of the most advanced protection and comfort features are reserved for higher-spec or available equipment rather than every version.

Should I buy a 2022 Mercedes-Benz S-Class or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 32.6% of listings are priced as good or great deals.
• Accident-free inventory is solid at 86.3% — always verify the vehicle history report.
• Price trend: Prices have softened 10.77% compared with last year.
• Owners rate it 4.5/5 — a strong satisfaction signal.
• It combines flagship luxury with a mild-hybrid six-cylinder or V8 powertrain and standard all-wheel drive.

Consider the 2021 if:

• At $58,717, the 2021 costs less than the current year's $63,247 average.
• It launched the redesigned S-Class with new powertrains and advanced technology.

Consider the 2023 if:

• At $78,407, the 2023 costs more than the current year's $63,247 average.
• It adds a new plug-in hybrid powertrain for buyers who want electric driving range.

The bottom line: If you want the best balance of price, inventory, and the latest version of this generation’s flagship luxury formula, the 2022 is the primary year to target. If your budget is tighter, the 2021 can save you money while still delivering the redesigned S-Class experience. If you want the newer powertrain direction and can spend more, the 2023 is the upgrade path.

These recommendations are based on CarGurus' proprietary market data from September 22, 2026, CarGurus experts' opinions, and generative AI.