Used 2022 Mercedes-Benz S-Class S 580 4MATIC AWD for SaleNationwide
266 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Manufaktur Exclus
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Porcelain / Espresso Brown Nap
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,000
- Stock #:
- C82365T
- VIN:
- W1K6G7GB1NA082365
Price drop
-$2,495
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
35,000 mi
Jonesboro, AR
Fair Deal
$70,124
$67,629
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 22,301
- Stock #:
- M848A
- VIN:
- W1K6G7GB2NA131587
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
22,301 mi
Normal, IL
Good Deal
$68,561
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Cashmere White Magno
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 68,139
- Stock #:
- 143770
- VIN:
- W1K6G7GB9NA143770
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
68,139 mi
Pinellas Park, FL
Fair Deal
$57,995
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- Automatic
- Mileage:
- 33,001
- Stock #:
- 25W3617A
- VIN:
- W1K6G7GB4NA139710
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
33,001 mi
Harvey, LA
Good Deal
$65,800
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 24,001
- Stock #:
- 180276A
- VIN:
- W1K6G7GBXNA138691
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
24,001 mi
Ontario, CA
Fair Deal
$71,106
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- Automatic
- Mileage:
- 42,140
- Stock #:
- 8598091A
- VIN:
- W1K6G7GB9NA118464
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
42,140 mi
West Palm Beach, FL
Great Deal
$58,888
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 61,406
- Stock #:
- 407465A
- VIN:
- W1K6G7GB6NA140647
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
61,406 mi
Lake Wales, FL
Fair Deal
$58,395
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 49,828
- Stock #:
- 6503
- VIN:
- W1K6G7GB4NA129887
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
49,828 mi
Denver, NC
Fair Deal
$64,785
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Selenite Grey)
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Carmine Red/Black
- Transmission:
- Automatic
- Mileage:
- 29,551
- Stock #:
- HPPTNA147119
- VIN:
- W1K6G7GB5NA147119
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
29,551 mi
Natick, MA
Fair Deal
$69,497
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 42,033
- Stock #:
- T1037
- VIN:
- W1K6G7GBXNA138061
Price drop
-$3,237
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
42,033 mi
Sunbury, OH
Great Deal
$63,667
$60,430
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black (040)
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Carmine Red/Black (507)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,374
- Stock #:
- 17296
- VIN:
- W1K6G7GB1NA121374
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
49,374 mi
Raleigh, NC
Fair Deal
$65,488
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 59,720
- Stock #:
- 139870
- VIN:
- W1K6G7GB4NA139870
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
59,720 mi
Cumming, GA
Fair Deal
$57,177
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 19,004
- Stock #:
- 17031
- VIN:
- W1K6G7GB1NA164645
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
19,004 mi
Burbank, IL
Great Deal
$60,735
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 50,715
- Stock #:
- NA148937X
- VIN:
- W1K6G7GB0NA148937
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
50,715 mi
Fresno, CA
Fair Deal
$62,079
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 66,258
- Stock #:
- 072602
- VIN:
- W1K6G7GB5NA072602
Price drop
-$2,000
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
66,258 mi
Lilburn, GA
Fair Deal
$57,898
$55,898
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 48,113
- Stock #:
- NA077481
- VIN:
- W1K6G7GB0NA077481
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
48,113 mi
Kennesaw, GA
Good Deal
$62,493
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,163
- Stock #:
- BU-35399BB
- VIN:
- W1K6G7GB9NA096210
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
41,163 mi
West Palm Beach, FL
Fair Deal
$64,698
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,665
- Stock #:
- CD6274A
- VIN:
- W1K6G7GB3NA133154
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
31,665 mi
Akron, OH
Fair Deal
$69,428
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,956
- Stock #:
- JU11430A
- VIN:
- W1K6G7GB0NA148727
Price drop
-$4,799
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
30,956 mi
Columbus, OH
Fair Deal
$68,989
$64,190
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 28,158
- Stock #:
- NA157308T
- VIN:
- W1K6G7GB3NA157308
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
28,158 mi
Fresno, CA
Good Deal
$66,984
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,680
- Stock #:
- 17068
- VIN:
- W1K6G7GB0NA143687
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,680 mi
Burbank, IL
Great Deal
$55,735
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 15,908
- Stock #:
- HP26191A
- VIN:
- W1K6G7GB4NA154952
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
15,908 mi
Atlanta, GA
Great Deal
$69,793
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,775
- Stock #:
- J8239
- VIN:
- W1K6G7GB3NA068239
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,775 mi
Fishers, IN
Good Deal
$63,099
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,386
- Stock #:
- 49777
- VIN:
- W1K6G7GB9NA149777
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,386 mi
Brentwood, TN
Good Deal
$63,399
FAQs
How much does the Mercedes-Benz S-Class S 580 4MATIC AWD cost?
The average Mercedes-Benz S-Class S 580 4MATIC AWD costs about $61,972.80. The average price has decreased by -6.3% since last year. The 556 for sale on CarGurus range from $43,984 to $110,411 in price.
How many Mercedes-Benz S-Class S 580 4MATIC AWD vehicles have no reported accidents or damage?
491 out of 556 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz S-Class S 580 4MATIC AWD?
Depending on the engine and options, the Mercedes-Benz S-Class S 580 4MATIC AWD gets between 20 and 20 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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