Used 2021 Mercedes-Benz S-Class for Sale nearIndianapolis, IN
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,489
- Stock #:
- I8151
- VIN:
- W1K6G6DB7NA128151
Sponsored by Fishers Imports
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
30,489 mi
$58,489
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Beigen
- Transmission:
- 9-Speed Automatic
- Mileage:
- 33,118
- Stock #:
- MA034911
- VIN:
- W1K6G7GB6MA034911
Sponsored Listing
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
33,118 mi
$62,736
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,772
- Stock #:
- J8239
- VIN:
- W1K6G7GB3NA068239
Sponsored Listing
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,772 mi
$64,972
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 96,096
- Stock #:
- 035527
- VIN:
- W1K6G7GBXMA035527
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
96,096 mi
$45,596
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,587
- Stock #:
- 067274
- VIN:
- W1K6G6DB2NA067274
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
32,587 mi
$55,857
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Buckskin Nappa
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,599
- Stock #:
- EP0213
- VIN:
- WDDUG8GB5LA501375
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
49,599 mi
$42,620
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- Magnetite Black Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 44,628
- Stock #:
- 11108
- VIN:
- WDDUG6EBXLA514744
2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
44,628 mi
$36,717
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- Automatic
- Mileage:
- 47,673
- Stock #:
- NA110345
- VIN:
- W1K6G7GB5NA110345
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
47,673 mi
$64,981
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 17,509
- Stock #:
- 26463A
- VIN:
- W1K6G6DB6MA031716
2021 Mercedes-Benz S-Class
S 500 Sedan 4MATIC
17,509 mi
$53,510
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,250
- Stock #:
- JB157483P
- VIN:
- W1K6G6DB1NA157483
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
23,250 mi
$60,313
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- Automatic
- Mileage:
- 39,377
- Stock #:
- 073511
- VIN:
- W1K6G7GB7NA073511
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
39,377 mi
$68,436
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Anthracite Blue
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- Automatic
- Mileage:
- 69,101
- Stock #:
- N23635
- VIN:
- W1K6G7GB4MA016634
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
69,101 mi
$52,490
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 82,300
- Stock #:
- 047837C01
- VIN:
- W1K6G7GB8MA047837
-$1,000
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
82,300 mi
$48,746
$47,746
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 158 currently listed for sale near Indianapolis, IN and an average price of $116,350.00, 30.4% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
81.6% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system, advanced safety features, and a choice of powerful engines, including a turbocharged inline-six and a twin-turbo V8.
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 603 hp 4L V8
- Exterior color:
- [040] Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Porcelain/Black
- Transmission:
- Automatic
- Mileage:
- 59,782
- Stock #:
- 426042
- VIN:
- WDDUG8JB7LA522009
![[040] Black 2020 Mercedes-Benz S-Class Sedan All-Wheel Drive Automatic](https://static.cargurus.com/images/forsale/2026/06/01/22/54/2020_mercedes-benz_s-class-pic-3335666247717155142-1024x768.jpeg?io=true&width=640&height=480&fit=bounds&format=jpg&auto=webp)
2020 Mercedes-Benz S-Class
S AMG 63 4MATIC Sedan AWD
59,782 mi
$67,648
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 63,212
- Stock #:
- 26308
- VIN:
- W1K6G6DB7NA105484
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
63,212 mi
$49,248
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,552
- Stock #:
- 7271
- VIN:
- W1K6G7GB5NA146617
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,552 mi
$68,902
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diam
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 25,965
- Stock #:
- 152088MM
- VIN:
- W1K6G7GB1NA152088
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
25,965 mi
$71,713
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 51,230
- Stock #:
- 7039
- VIN:
- W1K6G7GB8NA106497
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
51,230 mi
$65,902
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 18,278
- Stock #:
- 2315
- VIN:
- W1K6G7GB1NA097318
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
18,278 mi
$72,144
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- Lunar Blue Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silk Beige/Espresso Brown
- Transmission:
- Automatic
- Mileage:
- 47,611
- Stock #:
- P6583
- VIN:
- WDDUG6EB5LA511167
2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
47,611 mi
$34,398
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Nut Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 72,285
- Stock #:
- 147811BU
- VIN:
- W1KUG8GB7LA556037
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
72,285 mi
$39,087
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Manufaktur Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 54,876
- Stock #:
- 26305
- VIN:
- W1K6G6DB8NA166553
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
54,876 mi
$50,716
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,466
- Stock #:
- LA560016
- VIN:
- W1KUG8GB8LA560016
Sponsored Listing
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
36,466 mi
$51,236
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 158 currently listed for sale near Indianapolis, IN and an average price of $116,350.00, 30.4% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
81.6% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system, advanced safety features, and a choice of powerful engines, including a turbocharged inline-six and a twin-turbo V8.
Why it stands out
The 2021 Mercedes-Benz S-Class continues to uphold its reputation as a flagship luxury sedan, offering a blend of performance, comfort, and cutting-edge technology. With a redesigned exterior that boasts a drag coefficient of just 0.22, the S-Class not only looks elegant but also enhances fuel efficiency. Inside, the cabin is a showcase of luxury, featuring high-quality materials, ambient lighting with 64 color options, and a state-of-the-art infotainment system that includes a 12.8-inch OLED touchscreen. The S-Class is available in two configurations: the S500 4Matic with a 3.0-liter inline-six engine and the S580 4Matic with a 4.0-liter twin-turbo V8, both equipped with a mild-hybrid system for improved efficiency. The vehicle's advanced safety features, including adaptive cruise control and a rear-passenger airbag, further solidify its status as a leader in the luxury segment. While the price may be high, the S-Class offers an unparalleled driving experience that appeals to those seeking the best in automotive luxury.
Other model years to consider
- Average price: $116,350.00
- Good/great deal percentage: 25.7%
- Total listings: 265
- Average price: $115,000.00
- Good/great deal percentage: 28.3%
- User rating: 4.5 / 5
- Total listings: 233
- Average price: $56,000.00
- Good/great deal percentage: 31.7%
- User rating: 4.95 / 5
- Total listings: 221
This analysis is based on CarGurus' proprietary market data from July 21, 2026, CarGurus experts' opinions, and generative AI.
4.0 Overall rating
Filter by rating
Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
See more price trendsFAQs
How much does the 2021 Mercedes-Benz S-Class cost in Indianapolis, IN?
Is the 2021 Mercedes-Benz S-Class a good car?
How many 2021 Mercedes-Benz S-Class vehicles in Indianapolis, IN have no reported accidents or damage?
Is the 2021 Mercedes-Benz S-Class safe?
What is the fuel economy of the 2021 Mercedes-Benz S-Class?
What fuel types are available?
Relevant articles
The Best Sedans of 2026
As more people flock to SUVs and crossovers, some automakers are killing off sedans. But others are doubling down, building some of the best four-door cars we’ve ever driven. For a supposedly dying segment, the sedan market looks awfully healthy.
Mercedes-Benz S-Class Buying Guide: Cost, Reliability, and the Best Years to Buy
Discover the ultimate buying guide for purchasing a used Mercedes-Benz S-Class, covering every generation since 1951. Whether you're a first-time buyer or a Mercedes enthusiast, this comprehensive overview will help you research your next pre-owned Mercedes-Benz S-Class.
2026 Mercedes-Benz S-Class Pricing, Specs, and Release Date
Mercedes-Benz avoids drastic change with the 2026 S-Class sedan and instead refines the lineup with updated packages and configurations, plus a host of new paint colors and interior treatments.
