Used 2021 Mercedes-Benz S-Class for Sale near Indianapolis, IN
160 results
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 164 currently listed for sale near Indianapolis, IN and an average price of $127,890.00, 24.4% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.8% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features advanced technology, a luxurious interior, and powerful engine options, including a new mild-hybrid system.
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 164 currently listed for sale near Indianapolis, IN and an average price of $127,890.00, 24.4% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.8% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features advanced technology, a luxurious interior, and powerful engine options, including a new mild-hybrid system.
Why it stands out
The 2021 Mercedes-Benz S-Class remains a benchmark in the full-size luxury sedan market, noted for its impressive blend of luxury, technology, and performance. This latest generation introduces cutting-edge features, including a sophisticated infotainment system paired with a stunning 12.8-inch OLED touchscreen, enhancing the driving experience with intuitive controls and access to a myriad of functionalities. The S-Class is available in two variants: the S500 4Matic with a turbocharged inline-six engine and the S580 4Matic powered by a turbocharged V8, both of which deliver exhilarating performance and smooth handling. Owners have expressed high satisfaction due to its luxurious feel, technological advancements, and comfortable ride quality, although some have cited concerns regarding the run-flat tires. The overall combination of notable enhancements and enduring prestige continues to make the S-Class a compelling choice for discerning buyers.
Other model years to consider
- Average price: $66,514.00
- Good/great deal percentage: 22.7%
- User rating: 4.5 / 5
- Total listings: 233
- Average price: $74,350.00
- Good/great deal percentage: 20.2%
- Total listings: 243
- Average price: $26,641.00
- Good/great deal percentage: 20.8%
- User rating: 5 / 5
- Total listings: 202
This analysis is based on CarGurus' proprietary market data from April 28, 2026, CarGurus experts' opinions, and generative AI.
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Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
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