Used 2021 Mercedes-Benz S-Class for Sale near Indianapolis, IN
173 results
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 165 currently listed for sale near Indianapolis, IN and an average price of $64,329.00, 32.1% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
88.5% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class not only features impressive technology but also offers powerful engine options and a comfortable ride experience.
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 165 currently listed for sale near Indianapolis, IN and an average price of $64,329.00, 32.1% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
88.5% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class not only features impressive technology but also offers powerful engine options and a comfortable ride experience.
Why it stands out
The 2021 Mercedes-Benz S-Class is a standout in the luxury sedan category due to its blend of performance, technology, and comfort. It features powerful engine configurations, with the S500 offering 429 horsepower from a turbocharged inline-six and the S580 delivering an exhilarating 496 horsepower via a V8. The intuitive infotainment system is complemented by a luxurious interior, adorned with high-quality materials and advanced safety technologies, making it a sought-after choice for buyers seeking both prestige and innovation. Although some users noted concerns about run-flat tires, the overall handling and driving experience remain commendable, reinforcing its reputation as a flagship luxury vehicle.
Other model years to consider
- Average price: $74,631.00
- Good/great deal percentage: 24.7%
- Total listings: 239
- Average price: $68,007.00
- Good/great deal percentage: 30.7%
- User rating: 4.5 / 5
- Total listings: 215
- Average price: $34,500.00
- Good/great deal percentage: 32.4%
- User rating: 4.9 / 5
- Total listings: 136
This analysis is based on CarGurus' proprietary market data from May 19, 2026, CarGurus experts' opinions, and generative AI.
Relevant articles
Mercedes-Benz S-Class Buying Guide: Cost, Reliability, and the Best Years to Buy
Discover the ultimate buying guide for purchasing a used Mercedes-Benz S-Class, covering every generation since 1951. Whether you're a first-time buyer or a Mercedes enthusiast, this comprehensive overview will help you research your next pre-owned Mercedes-Benz S-Class.
The Best Sedans of 2026
As more people flock to SUVs and crossovers, some automakers are killing off sedans. But others are doubling down, building some of the best four-door cars we’ve ever driven. For a supposedly dying segment, the sedan market looks awfully healthy.
2026 Mercedes-Benz S-Class Pricing, Specs, and Release Date
Mercedes-Benz avoids drastic change with the 2026 S-Class sedan and instead refines the lineup with updated packages and configurations, plus a host of new paint colors and interior treatments.
4.0 Overall rating
Filter by rating
Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
See more price trends
