Used 2021 Mercedes-Benz E-Class for Sale nearSyracuse, NY
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Black
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Saddle Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,592
- Stock #:
- TC9965A
- VIN:
- WDDZF6JB4LA721368
Sponsored by NYE Automotive Group
2020 Mercedes-Benz E-Class
E 450 4MATIC AWD
40,592 mi
$34,434
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray (Graphite Grey Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 57,641
- Stock #:
- 967498
- VIN:
- W1KZF8EB9MA967498
2021 Mercedes-Benz E-Class
E 350 4MATIC
57,641 mi
$27,015
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Black
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 71,061
- Stock #:
- 818209
- VIN:
- W1KZF6JB9LA818209
-$1,000
2020 Mercedes-Benz E-Class
E 450 4MATIC AWD
71,061 mi
$28,574
$27,574
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 67,716
- Stock #:
- 9238
- VIN:
- W1KZF6BB3NB013379
2022 Mercedes-Benz E-Class
AMG E 53 Sedan 4MATIC
67,716 mi
$43,478
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 45,881
- Stock #:
- 70031564
- VIN:
- W1KZF8DB2MA922386
2021 Mercedes-Benz E-Class
E 350 RWD
45,881 mi
$31,997
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Blue
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 42,207
- Stock #:
- D5641L
- VIN:
- W1KZF6BB6MA906957
2021 Mercedes-Benz E-Class
AMG 53 E Sedan 4MATIC
42,207 mi
$47,459
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 56,276
- Stock #:
- AB7691A
- VIN:
- W1K1J6JBXLF133411
2020 Mercedes-Benz E-Class
E 450 4MATIC Coupe AWD
56,276 mi
$31,800
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Mojave Silver
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black/Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,010
- Stock #:
- V4600
- VIN:
- W1K1J6BB4MF161298
2021 Mercedes-Benz E-Class
AMG E 53 Coupe 4MATIC
23,010 mi
$53,504
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,706
- Stock #:
- P168247
- VIN:
- W1K1J5KB8MF168247
2021 Mercedes-Benz E-Class
E 450 4MATIC Coupe AWD
23,706 mi
$41,438
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 56,407
- Stock #:
- 920948
- VIN:
- W1KZF8DB8MA920948
2021 Mercedes-Benz E-Class
E 350 RWD
56,407 mi
$27,235
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,737
- Stock #:
- JB091344P
- VIN:
- W1KZF8DBXNB091344
2022 Mercedes-Benz E-Class
E 350 RWD
23,737 mi
$38,648
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 47,553
- Stock #:
- P26355
- VIN:
- W1K1J5JB8NF174858
2022 Mercedes-Benz E-Class
E 450 Coupe RWD
47,553 mi
$42,845
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L V6
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 106,168
- Stock #:
- R5654XQ
- VIN:
- WDDZF6JB7LA719968
2020 Mercedes-Benz E-Class
E 450 4MATIC AWD
106,168 mi
$26,026
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 838 currently listed for sale and an average price of $38,190.00, 34.6% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
75.7% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update that includes enhancements to the infotainment system, new engine options, and refined exterior styling.
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray (MANUFAKTUR Selenite Grey Magno)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 43,227
- Stock #:
- PH1249
- VIN:
- W1KZF6BB6NB030497
2022 Mercedes-Benz E-Class
AMG E 53 Sedan 4MATIC
43,227 mi
$50,481
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 75,290
- Stock #:
- K881344
- VIN:
- W1KZF8EB1MA881344
2021 Mercedes-Benz E-Class
E 350 4MATIC
75,290 mi
$26,947
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Mojave Silver Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,173
- Stock #:
- JB915973P
- VIN:
- W1KZF8DB4MA915973
-$900
2021 Mercedes-Benz E-Class
E 350 RWD
35,173 mi
$35,548
$34,648
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Convertible
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 29,260
- Stock #:
- 79LF126398T1
- VIN:
- WDD1K6BB4LF126398
-$2,084
2020 Mercedes-Benz E-Class
AMG E 53 Cabriolet 4MATIC
29,260 mi
$47,962
$45,878
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,622
- Stock #:
- 979886
- VIN:
- W1KZF8EB1MA979886
2021 Mercedes-Benz E-Class
E 350 4MATIC
45,622 mi
$28,278
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray (Selenite Grey Metallic)
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- Automatic
- Mileage:
- 42,170
- Stock #:
- RMU1753A
- VIN:
- W1KZF8EB4LA843881
2020 Mercedes-Benz E-Class
E 350 4MATIC AWD
42,170 mi
$25,659
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 48,423
- Stock #:
- H753164
- VIN:
- WDDZF8EB8LA753164
2020 Mercedes-Benz E-Class
E 350 4MATIC AWD
48,423 mi
$26,690
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 27,114
- Stock #:
- 018881T
- VIN:
- W1KZF8EB3NB018881
-$1,000
2022 Mercedes-Benz E-Class
E 350 4MATIC
27,114 mi
$33,990
$33,846
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Cirrus Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,021
- Stock #:
- 27420G
- VIN:
- W1KZF8EB4MA889003
2021 Mercedes-Benz E-Class
E 350 4MATIC
34,021 mi
$32,994
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 59,422
- Stock #:
- 185445
- VIN:
- W1K1J5JB5NF185445
2022 Mercedes-Benz E-Class
E 450 Coupe RWD
59,422 mi
$35,283
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall
Summary
With 838 currently listed for sale and an average price of $38,190.00, 34.6% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
75.7% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update that includes enhancements to the infotainment system, new engine options, and refined exterior styling.
Why it stands out
The 2021 Mercedes-Benz E-Class is a standout in the luxury midsize sedan segment, offering a blend of performance, comfort, and advanced technology. With multiple powertrain options, including a new hybrid inline-six engine, the E-Class caters to a variety of driving preferences, from efficiency to exhilarating performance. The interior is a hallmark of luxury, featuring high-quality materials, spacious seating, and an advanced infotainment system that enhances the driving experience. While some users have noted that certain advanced safety features are not standard, the overall package remains compelling for buyers seeking a sophisticated and versatile vehicle. The E-Class is designed to appeal to those who appreciate both style and substance, making it a top choice in its class.
Other model years to consider
- Average price: $31,618.00
- Good/great deal percentage: 36.0%
- User rating: 5 / 5
- Total listings: 991
- Average price: $41,015.00
- Good/great deal percentage: 33.8%
- User rating: 5 / 5
- Total listings: 1,081
- Average price: $23,350.00
- Good/great deal percentage: 36.1%
- User rating: 4.76 / 5
- Total listings: 1,402
This analysis is based on CarGurus' proprietary market data from July 13, 2026, CarGurus experts' opinions, and generative AI.
4.7 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
Elvis K. N
Reviewed a 2021 Mercedes-Benz E-Class on Jan 29, 2023
Very nice car but does not have active lane keeping assist.
Elvis E
Reviewed a 2021 Mercedes-Benz E 350 RWD on Apr 30, 2023
Best Car Ever! Great gas mileage. No problems so far at all! This is my 2nd Mercedes E-Class and I have no regrets buying it. Has great power. Can go really fast in seconds. If you like sporty exterior and luxury interior then this Mercedes Benz E350 2021 is the car for you!
2021 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| AMG E 53 Cabriolet 4MATIC | $82,850 |
| E 450 4MATIC Coupe AWD | $67,450 |
| E 450 Cabriolet RWD | $71,950 |
| AMG E 63 S Sedan 4MATIC | $107,500 |
| AMG 53 E Sedan 4MATIC | $73,900 |
| E 450 4MATIC Sedan AWD | $62,000 |
| E 350 4MATIC | $56,750 |
| E 350 RWD | $54,250 |
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
See more price trendsFAQs
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Is the 2021 Mercedes-Benz E-Class safe?
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2026 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Sitting squarely in the midsize luxury sedan segment, the 2026 Mercedes-Benz E-Class competes with the BMW 5 Series, the Audi A6, and the Lexus ES.
2025 Mercedes-Benz E-Class Pricing, Specs, and Release Date
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