Used 2021 Mercedes-Benz E-Class for Sale nearSaint Louis, MO

Compare 2021 Mercedes-Benz E-Class Trims

The E-Class offers a range of trims from budget-friendly options to luxurious performance models, catering to various preferences and needs.

• Starting at $28,807
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

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Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want a luxury sedan experience without the higher price tag of AWD options.

• Avg. market price: $28,807 (updated weekly)
• MPG/MPGe: 22 city / 31 hwy
• Inventory: 529 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the choice for those seeking all-wheel drive without a significant price increase, making it a popular option.

• Avg. market price: $29,500 (updated weekly)
• MPG/MPGe: 22 city / 30 hwy
• Inventory: 922 listings
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is ideal for buyers wanting a powerful engine and luxury features, though availability is limited.

• Avg. market price: $36,061 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 99 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is perfect for those who desire a stylish coupe with luxury features without the AWD premium.

• Avg. market price: $34,482 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 59 listings — lower availability; may limit negotiating room
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is for buyers seeking a sporty coupe with all-wheel drive and premium features.

• Avg. market price: $42,229 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 54 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is ideal for those wanting a luxurious convertible experience without the AWD cost.

• Avg. market price: $44,138 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 60 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

E 450 4MATIC Cabriolet AWD — "Who It's For"

The E 450 4MATIC Cabriolet AWD is for shoppers who want a luxurious convertible with all-wheel drive capabilities.

• Avg. market price: $39,416 (updated weekly)
• MPG/MPGe: 23 city / 29 hwy
• Inventory: 37 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Cabriolet AWD listings

AMG E 63 S Sedan 4MATIC — "Who It's For"

The AMG E 63 S Sedan 4MATIC is the choice for performance enthusiasts seeking a high-powered luxury sedan.

• Avg. market price: $81,338 (updated weekly)
• MPG/MPGe: 16 city / 23 hwy
• Inventory: 71 listings — lower availability; may limit negotiating room
• View AMG E 63 S Sedan 4MATIC listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 922 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 350 RWD

At $28,807 avg market price — below the lineup median of $37,738 — it's the most accessible entry point.

Browse E 350 RWD listings

Best for Fuel Economy — E 450 Coupe RWD

The E 450 Coupe RWD offers the best fuel economy in the lineup with 23 MPG city and 31 MPG highway.

Browse E 450 Coupe RWD listings

These recommendations are based on CarGurus' proprietary market data from September 12, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2021 Mercedes-Benz E-Class cost?

Prices have softened 15.81% compared to this time last year, making it a favorable time to shop this model year.

There are 795 listings available, which suggests you have a workable amount of inventory to compare.

Is the 2021 Mercedes-Benz E-Class a good car?

Yes — the 2021 Mercedes-Benz E-Class earns a 4.7/5 user rating and an 8.33/10 expert rating. The model scores 10/10 across Technology and Safety.

Owners consistently praise its blend of luxury, performance, and beautiful design, along with the comfortable interior and powerful engine. The review summary also points to advanced features as a major draw, while the overview frames the car as especially appealing if you want a premium vehicle that can be practical, versatile, and broadly configurable.

The main trade-offs are that some owners feel it is overpriced, and the expert notes say advanced safety features are not standard. That makes it a stronger fit if you value breadth, refinement, and tech more than bargain pricing or a stripped-down luxury experience.

With 34.0% of listings marked as good or great deals, there is enough market activity to shop selectively.

Is the 2021 Mercedes-Benz E-Class reliable?

Owners rate it 4.7/5, a strong signal of long-term satisfaction.

The owner feedback points to a car that feels dependable in daily use, with praise centered on its luxury, performance, and comfortable interior. The review summary also suggests that buyers tend to count on its blend of upscale design and advanced features over the long haul.

The expert notes reinforce that impression by describing the E-Class as a quiet, excellent choice for a car this size, with smooth operation from its electrified powertrains. The cost-effectiveness notes also suggest a practical ownership strategy: three-year-old off-lease examples can deliver strong value.

For used buyers, the biggest long-term risk is paying luxury-car money for a car whose upkeep and option content can make ownership costs climb quickly.

What should I look for when buying a used 2021 Mercedes-Benz E-Class?

Accident-free inventory is solid at 76.4% — always verify the vehicle history report.

You should still run a history report on every candidate, even if the listing looks clean at first glance. Prioritize a pre-purchase inspection that checks electronics, suspension behavior, and the condition of any high-value comfort or driver-assistance equipment. Because this car can be heavily optioned, focus on whether the specific example has the features you care about rather than assuming every E-Class is equipped the same way.

Key things to evaluate:

• Trim level: The cabin is richly finished even in baser trims, but the Luxury package’s softer-riding setup and standing hood ornament are no longer part of the lineup, and the Sport style is more common among buyers.
• Powertrain: The lineup includes multiple engines, from the base 2.0-liter turbo four-cylinder to electrified inline-six powertrains and the AMG E63 S’s 4.0-liter V8; the E450’s hybrid-assisted setup is quiet and excellent for this size.
• Safety package: Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard, while all other driver-assist features are optional.
• Infotainment: The car uses MBUX with two 12-inch screens, touch and swipe controls, natural voice processing, and online search; Apple CarPlay and Android Auto are standard but not wireless, and the system does not update over the air.
• Fuel efficiency: The E53 sedan is rated at 25 mpg combined, the E63 sedan at 18 mpg combined, the E450 4Matic sedan at 26 mpg combined, and the E350 4Matic sedan at 25 mpg combined.

Which 2021 Mercedes-Benz E-Class trim should I buy?

The 2021 Mercedes-Benz E-Class is offered in 13 trim levels: E350, E450, AMG E53, AMG E63 S, sedan, wagon, coupe, convertible, E350 4Matic, E450 4Matic, E450 coupe, E450 convertible, and E63 sedan.

Here's the short version:

• E350: This is the entry point if you want the E-Class experience at the lowest starting price, but the base four-cylinder is described as underwhelming, so it makes the most sense if you care more about the badge, cabin, and tech than acceleration.
• E450: This is the best-value choice for most shoppers because the electrified inline-six is quiet and excellent for a car this size, and it delivers the strongest balance of refinement and everyday performance.
• AMG E53: Choose this if you want quicker acceleration, rear-biased AWD, and the more athletic feel of the AMG-tuned setup without jumping all the way to the V8 model.
• AMG E63 S: This is the pick for maximum performance, with 603 hp, a lowered and stiffened chassis, and the most extreme character in the lineup.

Some safety features are optional, and advanced driver-assist equipment is not standard.

Is now a good time to buy a used 2021 Mercedes-Benz E-Class?

This is a moderate market for selective buyers, so you can shop carefully without expecting a fire sale.

• Deal availability: 34.0% of listings are priced as good or great deals.
• Inventory: There are 795 listings available.
• Price trend: Prices have softened 15.81% compared with last year.
• Clean inventory: 76.4% of listings are accident-free.

If you find a listing below $35,842, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Mercedes-Benz E-Class's resale value?

The current average of $35,881 sits slightly below last year's $42,620.

That drop suggests the market has already adjusted downward, which can help you buy at a more favorable point in the cycle. For a future seller, that also means your resale outcome will depend heavily on condition, mileage, and equipment rather than expecting the model to hold near its prior peak.

Because the year-over-year change is already negative, you should think of this as a car where depreciation has done some of the early work for you. If you buy well and keep the car in strong shape, you may be better positioned when it is time to sell.

Vehicles with strong owner satisfaction ratings, like this model year's 4.7/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Mercedes-Benz E-Class safe?

The 2021 E-Class sedan and wagon scored a five-star overall rating and five stars in frontal and side crash tests and for rollover vulnerability from NHTSA.

It earns a 10/10 safety score from our experts.

Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Other driver-assistance features are optional, and the expert notes make clear that advanced safety features are not standard across the lineup.

The safety writeup also notes that the driver's side received a four-star frontal crash rating versus the full five stars for 2020, which is worth keeping in mind if you are comparing model years.

Should I buy a 2021 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 34.0% of listings are priced as good or great deals.
• Accident-free inventory is solid at 76.4% — always verify the vehicle history report.
• Price trend: Prices have softened 15.81% compared with last year.
• Owners rate it 4.7/5 — a strong satisfaction signal.
• The 2021 update brings refreshed infotainment, engines, and exterior styling.

Consider the 2020 if:

• At $30,331, the 2020 costs less than the current year's $35,881 average.
• It offers the earlier version of the E-Class with a strong upscale presence and broad choice.

Consider the 2022 if:

• At $39,882, the 2022 costs more than the current year's $35,881 average.
• It carries forward the refresh and adds standard convenience features like automatic high beams.

The bottom line: If you want the best balance of price, updated tech, and broad appeal, the 2021 is the strongest all-around choice. If your priority is saving money, the 2020 is the better value play; if you want the newer carryover setup and can spend more, the 2022 is the cleaner step up.

These recommendations are based on CarGurus' proprietary market data from September 11, 2026, CarGurus experts' opinions, and generative AI.