Used 2021 Mercedes-Benz E-Class for Sale nearSaint Louis, MO

Compare 2021 Mercedes-Benz E-Class Trims

The E-Class offers a range of trims from budget-friendly options to sporty models, all featuring luxury and advanced technology.

• Starting at $28,169
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

Missing data displayed as "—".

Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want luxury features without the AWD price premium. It's the most budget-friendly option.

• Avg. market price: $28,169 (updated weekly)
• MPG/MPGe: 22 city / 31 hwy
• Inventory: 557 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the pick for shoppers who want all-wheel drive without a significant price increase. It's the most popular trim in the lineup.

• Avg. market price: $28,275 (updated weekly)
• MPG/MPGe: 22 city / 30 hwy
• Inventory: 1,060 listings — widest selection in the lineup
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is the pick for shoppers who want a sporty driving experience with all-wheel drive. It offers a powerful engine and advanced features.

• Avg. market price: $34,662 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 96 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is the pick for shoppers who want a stylish coupe with luxury features without going for the AWD option.

• Avg. market price: $34,294 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 57 listings — lower availability; may limit negotiating room
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is the pick for shoppers who want a premium coupe experience with all-wheel drive. It combines style and performance.

• Avg. market price: $33,942 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 52 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is the pick for shoppers who want a luxurious convertible experience without the AWD features.

• Avg. market price: $44,217 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 70 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

AMG E 53 Coupe 4MATIC — "Who It's For"

The AMG E 53 Coupe 4MATIC is the pick for shoppers who want a sporty coupe with advanced technology and performance features.

• Avg. market price: $44,999 (updated weekly)
• MPG/MPGe: 21 city / 28 hwy
• Inventory: 42 listings — lower availability; may limit negotiating room
• View AMG E 53 Coupe 4MATIC listings

AMG E 63 S Sedan 4MATIC — "Who It's For"

The AMG E 63 S Sedan 4MATIC is the pick for shoppers who want high-performance luxury without compromise. It's the ultimate in the E-Class lineup.

• Avg. market price: $70,040 (updated weekly)
• MPG/MPGe: 16 city / 23 hwy
• Inventory: 69 listings — lower availability; may limit negotiating room
• View AMG E 63 S Sedan 4MATIC listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 1,060 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 350 RWD

At $28,169 avg market price — below the lineup median of $34,478 — it's the most accessible entry point.

Browse E 350 RWD listings

Best for Fuel Economy — E 450 Coupe RWD

The E 450 Coupe RWD offers the best fuel economy in the lineup with 23 MPG city and 31 MPG highway.

Browse E 450 Coupe RWD listings

These recommendations are based on CarGurus' proprietary market data from November 12, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2021 Mercedes-Benz E-Class cost?

Prices have softened 10.55% compared to this time last year, making it a favorable time to shop this model year.

There are 856 listings available, which suggests you should have a workable selection to compare.

Is the 2021 Mercedes-Benz E-Class a good car?

Yes — the 2021 Mercedes-Benz E-Class earns a 4.7/5 user rating and an 8.3/10 expert rating. The model scores 10/10 across Technology and Safety.

Owners consistently praise its blend of luxury, performance, and beautiful design, along with its comfortable interior and advanced features. The E-Class also stands out for its powerful engine choices and polished everyday feel, while some shoppers note that it can feel overpriced and that certain features are not included.

From a use-case standpoint, it works well if you want a versatile luxury sedan that can be tailored toward comfort, performance, or efficiency. The market also shows 34.6% good or great deals, which gives you some room to shop selectively.

Is the 2021 Mercedes-Benz E-Class reliable?

Owners rate it 4.7/5, a strong signal of long-term satisfaction.

The owner feedback points to a car that many people feel good about living with over time, especially because it blends luxury with a comfortable interior and advanced features. The expert evaluation also describes it as a practical and versatile car, which supports the idea that it can be a dependable daily driver when properly maintained.

Mercedes also positions the E-Class as a sophisticated, well-engineered model with a strong emphasis on refinement and usability. For used buyers, the main long-term ownership risk is that a complex luxury car can become expensive if prior maintenance was skipped or if options and systems need repair.

What should I look for when buying a used 2021 Mercedes-Benz E-Class?

At 73.9% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.

You should start with a vehicle history report and confirm whether any prior damage was repaired properly. A pre-purchase inspection matters here because the E-Class can be loaded with technology and comfort features that are expensive to sort out later. Focus on condition, maintenance records, and whether the equipment on the car matches what you expect from the trim and options.

Key things to evaluate:

• Trim level: The cabin is richly appointed even in lower trims, but the more upscale versions add more decadent materials, richer finishes, and a more elaborate presentation. The base setup can feel less special than the higher-spec versions, so you should compare interior materials and equipment carefully.
• Powertrain: The lineup includes four engines, ranging from a base turbo four-cylinder to electrified inline-six and AMG V8 powertrains. The four-cylinder is described as underwhelming, while the six-cylinder and AMG versions deliver much stronger performance.
• Safety package: Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Other driver-assist features are optional, so you should verify exactly which systems are fitted on the car you are considering.
• Infotainment: The car uses MBUX with dual 12-inch screens, touch and swipe controls, natural voice processing, and online search. Apple CarPlay and Android Auto are standard, but they are not wireless, and the system does not update over the air.
• Fuel efficiency: The E53 sedan is rated at 22 mpg city and 29 mpg highway, while the E450 4Matic sedan returns 23 mpg city and 30 mpg highway. The E350 4Matic sedan is rated at 22 mpg city and 30 mpg highway, and the E63 sedan is rated at 16 mpg city and 23 mpg highway.

Which 2021 Mercedes-Benz E-Class trim should I buy?

The 2021 Mercedes-Benz E-Class is offered in 13 trim levels: E350, E450, AMG E53, AMG E63 S, sedan, wagon, coupe, convertible, E350 4Matic, E450 4Matic, E53 sedan, E63 sedan, and E450 coupe.

Here's the short version:

• E350: This is the entry point, but the base four-cylinder is described as underwhelming, so it makes the most sense if you want the E-Class experience at the lowest starting point and can live without the stronger powertrains.
• E450: This is the best-value choice for most shoppers because it brings the more satisfying electrified inline-six setup and a quieter, more excellent driving character without jumping all the way to AMG pricing.
• AMG E53: Choose this if you want the sharper performance edge, rear-biased AWD, and the more athletic suspension tuning while still keeping much of the E-Class comfort.
• AMG E63 S: This is the enthusiast pick, with the hand-built V8, lowered and widened chassis, and the most extreme performance in the lineup.

Advanced safety features are not standard, so make sure the specific car you choose has the driver-assist equipment you want.

Is now a good time to buy a used 2021 Mercedes-Benz E-Class?

This looks like a moderate, selective buyer’s market, so you can shop carefully and still find worthwhile listings.

• Deal availability: 34.6% of listings are priced as good or great deals.
• Inventory: There are 856 listings available.
• Price trend: Prices have softened 10.55% compared with last year.
• Clean inventory: 73.9% of listings are accident-free.

If you find a listing below $35,767, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Mercedes-Benz E-Class's resale value?

The current average of $35,924 sits slightly below last year's $40,161.

That decline suggests the market has already adjusted downward, which can help you buy more confidently today but may also limit short-term upside if you plan to resell soon. For future sellers, the current pricing trend means you should expect value retention to depend heavily on condition, mileage, and equipment.

Well-kept examples with desirable features should still attract attention because the E-Class has broad appeal and strong brand recognition. Vehicles with strong owner satisfaction ratings, like this model year's 4.7/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Mercedes-Benz E-Class safe?

The 2021 Mercedes-Benz E-Class sedan and wagon earn a five-star overall rating from NHTSA, with five-star ratings in frontal, side, and rollover tests, though the driver's side received a four-star rating in the frontal crash test.

It earns a 10/10 safety score from our experts.

Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Other driver-assistance features are optional, so you should confirm the exact safety equipment on any used example you consider.

The safety picture is strong overall, but the fact that advanced safety features are not standard means trim and option content matter a lot. That makes it especially important to verify the build sheet rather than assuming every E-Class has the same protection tech.

Should I buy a 2021 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 34.6% of listings are priced as good or great deals.
• At 73.9% accident-free, a meaningful share of listings has prior incidents — history verification is especially important.
• Price trend: Prices have softened 10.55% compared with last year.
• Owners rate it 4.7/5 — a strong satisfaction signal.
• The 2021 brings a mid-cycle update to the infotainment system, engines, and exterior styling.

Consider the 2020 if:

• At $29,750, the 2020 costs less than the current year's $35,924 average.
• It offers a stylish design and impressive technology with a more affordable entry point.

Consider the 2022 if:

• At $38,758, the 2022 costs more than the current year's $35,924 average.
• It keeps the refreshed formula and adds standard automatic high beams across the lineup.

The bottom line: The 2021 is the best all-around choice if you want the refreshed E-Class with strong tech, broad versatility, and a softer used-market price than newer examples. If you are more price-sensitive, the 2020 can make sense as a lower-cost way into the same basic experience.

How does the 2021 Mercedes-Benz E-Class compare to the 2021 BMW 5 Series?

Expert Pros & Cons (per CarGurus review team)

2021 Mercedes-Benz E-Class:

• Pros: Multiple powertrain options, Great ride quality, Impressive technology.
• Cons: Advanced safety features are not standard.

2021 BMW 5 Series:

• Pros: Multiple powertrain options, Great ride quality, Impressive technology.
• Cons: Advanced safety features are not standard.

Our experts score the 2021 Mercedes-Benz E-Class 8.3/10 and the 2021 BMW 5 Series 8/10. The E-Class has the edge in expert scoring, while both cars share the same broad strengths in powertrain variety, ride quality, and technology. The BMW is cheaper on the used market, but the E-Class offers the stronger overall expert impression and a slightly higher satisfaction signal.

Read our full side-by-side expert comparison here.

These recommendations are based on CarGurus' proprietary market data from November 10, 2026, CarGurus experts' opinions, and generative AI.