Used 2021 Mercedes-Benz S-Class for Sale near Portland, OR
136 results
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 129 currently listed for sale near Portland, OR and an average price of $63,949.00, 24.8% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
78.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a state-of-the-art infotainment setup and offers both the S500 and S580 configurations, boasting impressive horsepower and an array of luxury amenities.
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 129 currently listed for sale near Portland, OR and an average price of $63,949.00, 24.8% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
78.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a state-of-the-art infotainment setup and offers both the S500 and S580 configurations, boasting impressive horsepower and an array of luxury amenities.
Why it stands out
The 2021 Mercedes-Benz S-Class represents the pinnacle of luxury sedans, combining powerful performance with advanced technology. The S-Class is offered in two configurations: the S500 4Matic with a 3.0-liter turbocharged inline-six engine producing 429 horsepower, and the S580 4Matic featuring a 4.0-liter twin-turbo V8 that delivers an exhilarating 496 horsepower. Not only does this powerful engine setup provide thrilling acceleration, but with the inclusion of EQ Boost mild-hybrid technology, the S-Class also offers enhanced efficiency.
Luxury abounds with features such as a 12.8-inch OLED touchscreen, an expansive digital instrument cluster, and lavish interior materials including Nappa leather upholstery. The innovative ambient lighting system sets the atmosphere at a level rarely seen in the automotive industry, and the impressive technology suite keeps drivers informed and entertained. Although the S-Class does carry a high price point, its solid construction, luxurious feel, and the prestige associated with the Mercedes-Benz badge make it a compelling choice for discerning buyers.
Other model years to consider
- Average price: $69,786.00
- Good/great deal percentage: 19.1%
- User rating: 4.5 / 5
- Total listings: 183
- Average price: $98,149.00
- Good/great deal percentage: 18.6%
- Total listings: 183
- Average price: $29,516.00
- Good/great deal percentage: 16.9%
- User rating: 5 / 5
- Total listings: 130
This analysis is based on CarGurus' proprietary market data from April 14, 2026, CarGurus experts' opinions, and generative AI.
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Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
See more price trends
