Used 2021 Mercedes-Benz S-Class for Sale near Cleveland, OH

## Summary - With 157 currently listed for sale near Cleveland, OH and an **average price of $58,749.00**, 38.9% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals. - **Favorably reviewed:** Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars. - **82.8% of 2021 S-Class models on CarGurus are accident free**. - The 2021 Mercedes-Benz S-Class features a redesigned interior with advanced technology, powerful engine options, and a luxurious driving experience. ## Why it stands out The 2021 Mercedes-Benz S-Class stands as a paragon of luxury and innovation, incorporating advanced technology and performance enhancements that define the segment. With two robust configurations—the S500 and S580, featuring a turbocharged inline-six and a twin-turbo V8, respectively—this flagship model showcases unmistakable power and refinement. Each variant not only offers exceptional horsepower but also integrates EQ Boost mild-hybrid systems for improved efficiency. The car's exterior has received aerodynamic refinements, ensuring that it glides through the air with notable grace. Inside, the S-Class redefines luxury with its expansive touchscreen interface, ambient lighting with 64 color options, and the latest MBUX infotainment system, which offers personalized user profiles. Amid its strengths—superior comfort and cutting-edge technology—some reviewers have mentioned the high purchase price and minor issues with the run-flat tires, yet these do little to diminish its standing as a top luxury vehicle. ## Other model years to consider - **[2022 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2022-Mercedes-Benz-S-Class-Cleveland-c31858_L27014)** - Average price: $66,801.00 - Good/great deal percentage: 30.2% - User rating: 4.8 / 5 - Total listings: 202 - **[2015 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2015-Mercedes-Benz-S-Class-Cleveland-c24430_L27014)** - Average price: $22,946.00 - Good/great deal percentage: 29.1% - User rating: 4.88 / 5 - Total listings: 203 - **[2019 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2019-Mercedes-Benz-S-Class-Cleveland-c28135_L27014)** - Average price: $68,422.00 - Good/great deal percentage: 41.6% - User rating: 4.85 / 5 - Total listings: 154 This analysis is based on CarGurus' proprietary market data from March 19, 2026, CarGurus experts' opinions, and generative AI.