Used 2021 Mercedes-Benz S-Class for Sale near Cleveland, OH
160 results
CarGurus Analysis:
2021 Mercedes-Benz S-Class
- With 160 currently listed for sale near Cleveland, OH and an average price of $95,495.00, 33.1% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
- Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars.
- 83.8% of 2021 S-Class models on CarGurus are accident free.
- The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system and advanced technology, along with an impressive ride quality that combines power and comfort.
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall

Summary
- With 160 currently listed for sale near Cleveland, OH and an average price of $95,495.00, 33.1% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
- Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars.
- 83.8% of 2021 S-Class models on CarGurus are accident free.
- The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system and advanced technology, along with an impressive ride quality that combines power and comfort.
Why it stands out
The 2021 Mercedes-Benz S-Class is a standout in the luxury sedan segment, renowned for its combination of opulence and ground-breaking technology. This model showcases Mercedes' commitment to innovation, featuring a refreshed infotainment system and a range of engines that include a powerful V8 option in the S580, providing 496 hp and 516 lb-ft of torque. With the introduction of EQ Boost mild-hybrid technology, it enhances efficiency without sacrificing performance. Owners appreciate the luxurious interior, fitted with premium materials and an extensive ambient lighting system that caters to their comfort and aesthetic preferences. The vehicle also boasts advanced safety features, including a rear-passenger airbag and a comprehensive suite of driver-assist technologies that enhance the driving experience. While the price tag is steep, the blend of performance, luxury, and cutting-edge features makes the S-Class an appealing choice for buyers seeking a premium driving experience.
Other model years to consider
- Average price: $79,801.00
- Good/great deal percentage: 28.5%
- User rating: 4.8 / 5
- Total listings: 207
- Average price: $22,923.00
- Good/great deal percentage: 29.2%
- User rating: 4.88 / 5
- Total listings: 202
- Average price: $21,995.00
- Good/great deal percentage: 28.4%
- User rating: 4.89 / 5
- Total listings: 162
This analysis is based on CarGurus' proprietary market data from March 31, 2026, CarGurus experts' opinions, and generative AI.
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Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
James B
Reviewed a 2021 Mercedes-Benz S 580 Sedan 4MATIC on Oct 14, 2024
The car is loaded with luxuries , very stylish at the same time sporty. You get a lot of car for the money and they hold there value. BMW would be close cusin to Mercedes.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
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