Used 2021 Mercedes-Benz S-Class for Sale near Detroit, MI
164 results
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 179 currently listed for sale near Detroit, MI and an average price of $59,352.00, 12.3% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
79.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a redesigned infotainment system, enhanced powertrains, and remarkable comfort options like heated and ventilated seats with massage functions.
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 179 currently listed for sale near Detroit, MI and an average price of $59,352.00, 12.3% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
79.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a redesigned infotainment system, enhanced powertrains, and remarkable comfort options like heated and ventilated seats with massage functions.
Why it stands out
The 2021 Mercedes-Benz S-Class continues to uphold its reputation as a leader in the luxury sedan market with notable advancements and refinements. The redesign introduces both the S500 and S580 configurations, which come equipped with powerful engines and innovative EQ Boost mild-hybrid technology for improved performance and efficiency. The S-Class is celebrated for its luxurious interior, which offers top-tier materials, ambient lighting, and an impressive array of technology, including a 12.8-inch OLED touchscreen and advanced driver-assistance systems. While it enjoys rapid acceleration and superior handling, the high price tag might be a consideration for certain buyers. Overall, the S-Class excels in comfort, technology, and performance, maintaining its position as a prestigious choice among luxury sedans.
Other model years to consider
- Average price: $87,552.00
- Good/great deal percentage: 16.3%
- User rating: Not available
- Total listings: 246
- Average price: $21,154.00
- Good/great deal percentage: 16.0%
- User rating: 5 / 5
- Total listings: 212
- Average price: $65,844.00
- Good/great deal percentage: 14.4%
- User rating: 4.5 / 5
- Total listings: 243
This analysis is based on CarGurus' proprietary market data from April 21, 2026, CarGurus experts' opinions, and generative AI.
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Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
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