Used 2021 Mercedes-Benz S-Class for Sale nearCharlottesville, VA
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Cashmere White Magno
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Sienna Brown/Black
- Transmission:
- Automatic
- Mileage:
- 45,506
- Stock #:
- IV137187P
- VIN:
- W1K6G7GB5NA137187
Sponsored by Passport INFINITI of Alexandria
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
45,506 mi
$65,895
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 107,794
- Stock #:
- 560055
- VIN:
- W1KUG8GB7LA560055
-$2,324
Sponsored Listing
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
107,794 mi
$31,289
$28,965
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Graphite Grey)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- Automatic
- Mileage:
- 39,376
- Stock #:
- P6682
- VIN:
- W1K6G7GB1MA036369
Sponsored Listing
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
39,376 mi
$59,499
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 29,607
- Stock #:
- X166139
- VIN:
- W1K6G7GB7NA166139
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
29,607 mi
$73,272
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,826
- Stock #:
- BA156735
- VIN:
- W1K6G6DB8NA156735
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
45,826 mi
$56,990
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Red
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- Automatic
- Mileage:
- 13,455
- Stock #:
- S122151
- VIN:
- W1K6G7GB8NA122151
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
13,455 mi
$75,225
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Sahara Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,972
- Stock #:
- P2462M
- VIN:
- W1KUG8GB5LA556196
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
46,972 mi
$46,307
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 67,530
- Stock #:
- FB0169
- VIN:
- W1K6G7GB9NA072019
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
67,530 mi
$57,789
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 21,316
- Stock #:
- 23338
- VIN:
- W1K6G6DB1NA164952
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
21,316 mi
$65,994
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,987
- Stock #:
- MA047653
- VIN:
- W1K6G7GB9MA047653
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
58,987 mi
$58,518
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Kalahari Gold
- Combined gas mileage:
- 19 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 3,929
- Stock #:
- T082643A
- VIN:
- W1K6X7GB3NA082643
2022 Mercedes-Benz S-Class
Maybach S 580 4MATIC AWD
3,929 mi
$137,307
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- Lunar Blue Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silk Beige/Espresso Brown
- Transmission:
- Automatic
- Mileage:
- 47,611
- Stock #:
- P6583
- VIN:
- WDDUG6EB5LA511167
2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
47,611 mi
$32,999
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,223
- Stock #:
- 037124
- VIN:
- W1K6G7GB9MA037124
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
58,223 mi
$54,014
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 693 currently listed for sale and an average price of $60,995.00, 33.0% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars and CarGurus experts gave it a 7.5 / 10.
81.0% of 2021 S-Class models on CarGurus are accident free.
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 61,739
- Stock #:
- 521126
- VIN:
- WDDUG8DB1LA521126
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
61,739 mi
$33,570
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Champagne
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- Automatic
- Mileage:
- 59,002
- Stock #:
- MA030859
- VIN:
- W1K6G7GBXMA030859
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
59,002 mi
$54,890
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,644
- Stock #:
- ND3822
- VIN:
- W1K6G6DB9NA129270
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
35,644 mi
$60,731
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Cashmere White Magno
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Sienna Brown/Black
- Transmission:
- Automatic
- Mileage:
- 45,506
- Stock #:
- IV137187P
- VIN:
- W1K6G7GB5NA137187
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
45,506 mi
$65,895
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gold Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 14,223
- Stock #:
- UMC7433
- VIN:
- W1K6G6DB3NA137624
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
14,223 mi
$64,995
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 15,230
- Stock #:
- P136719A
- VIN:
- W1K6G7GB7NA136719
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
15,230 mi
$79,403
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 104,617
- Stock #:
- 569763
- VIN:
- W1KUG8DB7LA569763
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
104,617 mi
$28,570
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 70,026
- Stock #:
- 149146
- VIN:
- W1K6G7GB7NA149146
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
70,026 mi
$56,966
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 45,594
- Stock #:
- 28731830
- VIN:
- W1K6G6DB9MA032813
2021 Mercedes-Benz S-Class
S 500 Sedan 4MATIC
45,594 mi
$52,547
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Grey)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 22,134
- Stock #:
- BA164867
- VIN:
- W1K6G6DBXNA164867
Sponsored Listing
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
22,134 mi
$65,990
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 693 currently listed for sale and an average price of $60,995.00, 33.0% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars and CarGurus experts gave it a 7.5 / 10.
81.0% of 2021 S-Class models on CarGurus are accident free.
Why it stands out
Mercedes gives its flagship an overhaul, and the 2021 Mercedes-Benz S-Class is built to reinforce exactly why the nameplate sits at the top of the brand’s hierarchy. It has long served as a technological showcase, and Mercedes has used the redesigned sedan to introduce innovations that eventually trickled down to mainstream vehicles. For buyers, that means the appeal is not just prestige, but also the sense that the car is meant to showcase the latest thinking in luxury, comfort, and technology.
The 2021 S-Class also arrives with a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork. It launches in two configurations, both with 4Matic all-wheel drive and EQ Boost mild-hybrid systems: the S500 4Matic uses a six-cylinder engine, while the S580 4Matic uses a V8. That combination makes the car sound as advanced as it is luxurious, and the available power is a clear strength. The main drawback is straightforward: it carries a high price.
Other model years to consider
- Average price: $78,240.00
- Good/great deal percentage: 32.4%
- Accident-free percentage: 88.7%
- Total listings: 1,209
- Average price: $63,618.00
- Good/great deal percentage: 32.0%
- User rating: 4.5 / 5
- Total listings: 1,097
- Average price: $25,288.00
- Good/great deal percentage: 32.2%
- User rating: 4.95 / 5
- Total listings: 922
This analysis is based on CarGurus' proprietary market data from August 17, 2026, CarGurus experts' opinions, and generative AI.
4.0 Overall rating
Filter by rating
Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
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