Used 2021 Mercedes-Benz E-Class for Sale near Santa Rosa, CA

## Summary - With 907 currently listed for sale on CarGurus and an **average price of $38,758**, 32.7% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals. - **Favorably reviewed:** Owners rated the 2021 Mercedes-Benz E-Class 4.53 / 5 stars. - **76.8% of 2021 E-Class models on CarGurus are accident free**. - The 2021 Mercedes-Benz E-Class received a mid-cycle update that includes new infotainment systems, updated engines, and exterior styling enhancements, offering a balance of luxury and performance. ## Why it stands out The 2021 Mercedes-Benz E-Class expertly combines performance, luxurious features, and advanced technology, making it an appealing choice for buyers looking for a versatile midsize luxury sedan. The model offers multiple powertrain options, including hybrid systems that enhance efficiency without sacrificing power, with the E450 generating 362 hp and featuring a mild-hybrid setup. Updates for 2021 include a refined design that moves away from the former model's sharper angles to a more elegant profile, as well as improvements in the infotainment system with a 12-inch digital display. This vehicle stands out for its high-quality interior materials, which create an inviting atmosphere with lavish styling elements. However, some users have noted concerns regarding certain driver-assistance features and the exclusive use of synthetic leather in some trims. Coupled with a strong user satisfaction rating of 4.53 stars and an impressive accident-free percentage, the 2021 E-Class represents a compelling option within its class. ## Other model years to consider - **[2022 Mercedes-Benz E-Class](https://www.cargurus.com/Cars/l-Used-2022-Mercedes-Benz-E-Class-c31854)** - Average price: $40,720.00 - Good/great deal percentage: 32.2% - User rating: 5 / 5 - Total listings: 1,069 - **[2023 Mercedes-Benz E-Class](https://www.cargurus.com/Cars/l-Used-2023-Mercedes-Benz-E-Class-c32301)** - Average price: $50,530.00 - Good/great deal percentage: 34.1% - User rating: 5 / 5 - Total listings: 925 This analysis is based on CarGurus' proprietary market data from March 9, 2026, CarGurus experts' opinions, and generative AI.