Used 2021 Mercedes-Benz E-Class for Sale near Key West, FL
103 results
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 810 currently listed for sale and an average price of $38,962.00, 33.6% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
74.2% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update that includes improvements to its infotainment system, engine options, and exterior styling, making it both luxurious and practical.
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall
Summary
With 810 currently listed for sale and an average price of $38,962.00, 33.6% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars.
74.2% of 2021 E-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz E-Class features a mid-cycle update that includes improvements to its infotainment system, engine options, and exterior styling, making it both luxurious and practical.
Why it stands out
The 2021 Mercedes-Benz E-Class makes a strong impression with its blend of luxury and performance characteristics. This model offers a selection of four body styles and various powerful engine choices, allowing buyers to tailor the vehicle to their preferences. The interior is richly appointed with high-quality materials and advanced technology, highlighting its status as a luxury sedan. Notable improvements for 2021 include a more sophisticated infotainment system and an updated engine lineup, including electrified options that offer enhanced fuel efficiency. While some reviewers mention certain features as lacking given the vehicle’s price point, the overall experience of driving the E-Class remains smooth and powerful. With its strong user ratings, this model balances luxury, technology, and comfort effectively, making it appealing to discerning buyers.
Other model years to consider
- Average price: $40,933.00
- Good/great deal percentage: 34.3%
- User rating: 5 / 5
- Total listings: 1,040
- Average price: $23,800.00
- Good/great deal percentage: 34.3%
- User rating: 4.76 / 5
- Total listings: 1,372
- Average price: $30,856.00
- Good/great deal percentage: 33.3%
- User rating: 5 / 5
- Total listings: 943
This analysis is based on CarGurus' proprietary market data from June 8, 2026, CarGurus experts' opinions, and generative AI.
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2026 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Sitting squarely in the midsize luxury sedan segment, the 2026 Mercedes-Benz E-Class competes with the BMW 5 Series, the Audi A6, and the Lexus ES.
2025 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Thoroughly updated last year, the Mercedes-Benz E-Class returns for 2025 with added safety equipment, a new entry-level trim, and an AMG E 53 Hybrid version designed to deliver equal parts performance and efficiency.
4.7 Overall rating
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ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
Elvis K. N
Reviewed a 2021 Mercedes-Benz E-Class on Jan 29, 2023
Very nice car but does not have active lane keeping assist.
Elvis E
Reviewed a 2021 Mercedes-Benz E 350 RWD on Apr 30, 2023
Best Car Ever! Great gas mileage. No problems so far at all! This is my 2nd Mercedes E-Class and I have no regrets buying it. Has great power. Can go really fast in seconds. If you like sporty exterior and luxury interior then this Mercedes Benz E350 2021 is the car for you!
2021 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| E 450 4MATIC Coupe AWD | $67,450 |
| E 450 Cabriolet RWD | $71,950 |
| AMG E 63 S Wagon 4MATIC | $112,450 |
| E 450 4MATIC Sedan AWD | $62,000 |
| AMG 53 E Sedan 4MATIC | $73,900 |
| AMG E 63 S Sedan 4MATIC | $107,500 |
| E 350 4MATIC | $56,750 |
| E 350 RWD | $54,250 |
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
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