Used 2021 Mercedes-Benz E-Class for Sale near Appleton, WI

## Summary - With 921 currently listed for sale on CarGurus and an **average price of $38,281.00**, 32.4% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals. - **Favorably reviewed:** Owners rated the 2021 Mercedes-Benz E-Class 4.53 / 5 stars and CarGurus experts gave it an 8.33 / 10. - **75.8% of 2021 E-Class models on CarGurus are accident free**. - The 2021 Mercedes-Benz E-Class introduced modest changes including a mid-cycle update in infotainment, engines, and exterior styling, maintaining its reputation as a versatile luxury sedan. ## Why it stands out The 2021 Mercedes-Benz E-Class differentiates itself with its luxurious interior and impeccable performance. Not only does it offer various body styles and powertrain options—including a new hybrid inline-six engine—but it also features a striking design that appeals to the luxury-savvy market. The E-Class provides a smooth ride and high-quality materials throughout the cabin, ensuring an elevated driving experience. However, some users noted concerns regarding advanced safety features and the use of artificial leather in place of genuine leather. Overall, the 2021 model remains a strong contender for those seeking a sophisticated yet practical vehicle, as highlighted in the expert review which emphasizes its blend of luxury and versatility. ## Other model years to consider - **[2022 Mercedes-Benz E-Class](https://www.cargurus.com/Cars/l-Used-2022-Mercedes-Benz-E-Class-c31854)** - Average price: $40,599.00 - Good/great deal percentage: 32.1% - User rating: 5 / 5 - Total listings: 1,088 - **[2019 Mercedes-Benz E-Class](https://www.cargurus.com/Cars/l-Used-2019-Mercedes-Benz-E-Class-c28109)** - Average price: $27,650.00 - Good/great deal percentage: 32.4% - User rating: 4.88 / 5 - Total listings: 1,161 - **[2018 Mercedes-Benz E-Class](https://www.cargurus.com/Cars/l-Used-2018-Mercedes-Benz-E-Class-c27070)** - Average price: $24,026.00 - Good/great deal percentage: 32.4% - User rating: 4.68 / 5 - Total listings: 1,301 This analysis is based on CarGurus' proprietary market data from March 2, 2026, CarGurus experts' opinions, and generative AI.