at 55 to 65mph it sounds like bad bearing changed all 4 wheel bearings. rotated all tires. It does it more frequent in 4 wheel drive. It sounds like you are running over rumble strips. Doesn't do it all the time.
could be anything..are the tires not out of round>does it do it more when its colder outside?? really there not enough info,gringing noise?
There was a recall on 2010 F-150's with two piece drive shafts. I have one. Didn't make the noise you indicate, but maybe worth a check.
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