at 55 to 65mph it sounds like bad bearing changed all 4 wheel bearings. rotated all tires. It does it more frequent in 4 wheel drive. It sounds like you are running over rumble strips. Doesn't do it all the time.
could be anything..are the tires not out of round>does it do it more when its colder outside?? really there not enough info,gringing noise?
There was a recall on 2010 F-150's with two piece drive shafts. I have one. Didn't make the noise you indicate, but maybe worth a check.
Looking for a Used F-150 in your area?
CarGurus has 215,477 nationwide F-150 listings starting at $1,300.
Search Ford F-150 Questions
Ford F-150 Experts
Related Models For Sale