The 2000 Mercedes-Benz E320 four-door wagon with 4Matic all-wheel-drive received a styling update that included a new hood, grille, bumpers, and taillights, as well as new 16-inch wheels. Inside, the E320 wagon received upgraded leather, carpeting, and woodgrain trim, as well as a new instrument panel.
The E320 wagon also received a number of new standard features, including the TeleAid emergency communication and assistance program, and the Electronic Stability Programming (ESP) anti-skid system.
In addition, the 4Matic all-wheel-drive system provided improved handling, stability, and traction in all types of driving conditions.
The E320 wagon was powered by a 3.2-liter V6 engine that produced 221 horsepower. The standard transmission was a five-speed automatic, which for 2000 was equipped with the new Touch Shift feature, enabling the driver to upshift and downshift by nudging the shift lever left or right.
The E320 wagon came with third-row seating that folded down to provide additional cargo space. The E320 wagon provided the most cargo capacity of any vehicle in its class, according to reports.
Standard features for the E320 wagon included leather seats with power adjustment in the front, a two-zone automatic climate control system, dual front and side airbags, power windows, power exterior mirrors, cruise control, a leather-trimmed steering wheel and shift knob, a lighted entry system, trip computer, and AM/FM audio system with a cassette player.
A CD player was available as an option. Other options included a sunroof, a parking alert system, and Mercedes' COMAND navigation system.
The E320 wagon also came with anti-lock brakes, traction control, and an anti-theft alarm system.
Drivers noted that the E320 wagon handled well, although acceleration was noticeable slower than the E320 sedan's. In addition, the wagon's new styling and interior upgrades were a hit with drivers. However, some drivers noted having electrical problems with the car.