2022 Lexus IS vs 2022 Mercedes-Benz S-Class

2022 Lexus IS
2022 Lexus IS
$39,125MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now
2022 Lexus IS
$39,125MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now

Overview

MSRP

$39,125

MSRP

$111,100

Listings

254

Listings

470

Ratings & Reviews

User Reviews
User Reviews

Expert reviews

8.2 out of 10

Expert reviews

8.7 out of 10

Pros

  • Fun to drive

  • Easy-to-use technology

  • Standard advanced safety features

Cons

  • Not much cargo space

  • Noisy

  • Poor value for money

Pros

  • Stylish design

  • Great ride quality

  • Premium interior materials

Cons

  • Potentially polarizing design

  • No getting around the high price tag

2022 Lexus IS Reviews Summary

After a substantial refresh for the 2021 model year, the 2022 Lexus IS lineup returns with a handful of minor updates and a significant improvement in performance. The new 2022 Lexus IS 500 F Sport Performance also debuts this year, packing a normally-aspirated 5.0-liter V8 and laugh-riot driving dynamics. We sampled the new 2022 IS 500 in the suburbs and outskirts of Phoenix, and if you’re among the driving enthusiasts who miss the discontinued Lexus GS F, this is a credible substitute.

2022 Mercedes-Benz S-Class Reviews Summary

The 2022 Mercedes-Benz S-Class is a full-size four-door luxury sedan with a 48-volt mild hybrid gasoline-electric powertrain, including a turbocharged 3.0-liter inline six-cylinder gas engine (S500) or twin-turbo 4.0-liter V8 (S580), with EQ Boost, a nine-speed automatic transmission, and all-wheel drive (AWD). The S500 starts at $111,100; the S580 starts at $117,700. The EPA estimates the S500 can achieve fuel economy of up to 21 mpg city/30 mpg highway/24 mpg combined, while the S580 is rated at 16 mpg city/25 mpg highway/19 mpg combined.
No video found

Popular Features & Specs

Engine

2.0L 241 hp I4

Engine

3.0L 429 hp I6

Drive Train

RWD

Drive Train

AWD

Seating Capacity

5

Seating Capacity

5

Horsepower

241 hp @ 5800 rpm

Horsepower

429 hp @ 6100 rpm

MPG City

21

MPG City

21

MPG Highway

31

MPG Highway

30
2022 Lexus IS
2022 Lexus IS
$39,125MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now
2022 Lexus IS
$39,125MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now

Overview

MSRP
$39,125
$111,100
Listings

Ratings & Reviews

User reviews

5.0

4.8

Expert reviews

8.2 out of 10

Read full review

8.7 out of 10

Read full review
Pros & cons

Pros

  • Fun to drive

  • Easy-to-use technology

  • Standard advanced safety features

Cons

  • Not much cargo space

  • Noisy

  • Poor value for money

Pros

  • Stylish design

  • Great ride quality

  • Premium interior materials

Cons

  • Potentially polarizing design

  • No getting around the high price tag

Summary
After a substantial refresh for the 2021 model year, the 2022 Lexus IS lineup returns with a handful of minor updates and a significant improvement in performance. The new 2022 Lexus IS 500 F Sport Performance also debuts this year, packing a normally-aspirated 5.0-liter V8 and laugh-riot driving dynamics. We sampled the new 2022 IS 500 in the suburbs and outskirts of Phoenix, and if you’re among the driving enthusiasts who miss the discontinued Lexus GS F, this is a credible substitute.
The 2022 Mercedes-Benz S-Class is a full-size four-door luxury sedan with a 48-volt mild hybrid gasoline-electric powertrain, including a turbocharged 3.0-liter inline six-cylinder gas engine (S500) or twin-turbo 4.0-liter V8 (S580), with EQ Boost, a nine-speed automatic transmission, and all-wheel drive (AWD). The S500 starts at $111,100; the S580 starts at $117,700. The EPA estimates the S500 can achieve fuel economy of up to 21 mpg city/30 mpg highway/24 mpg combined, while the S580 is rated at 16 mpg city/25 mpg highway/19 mpg combined.
Video
No video found

Popular Features & Specs

Engine
2.0L 241 hp I4
3.0L 429 hp I6
Drive Train
RWD
AWD
Seating Capacity
5
5
Horsepower
241 hp @ 5800 rpm
429 hp @ 6100 rpm
MPG City
21
21
MPG Highway
31
30
Look and feel

2022 Lexus IS

9/10

2022 Mercedes-Benz S-Class

9/10

The 2022 Lexus IS 500 F Sport Performance carried forward the legacy of the original 2008 Lexus IS F, featuring a naturally aspirated 5.0-liter V8 engine. This engine produced 472 horsepower and 395 lb-ft of torque, channeled to the rear wheels via an eight-speed automatic transmission. Priced at $56,500 plus a $1,075 destination charge, the IS 500 F Sport Performance offered a thrilling driving experience, blending emotional excitement with daily driving comfort. Despite its higher cost compared to other IS models, the IS 500 F Sport Performance justified its price with premium features like triple-beam headlights, a navigation system, and a 17-speaker Mark Levinson sound system.

The 2022 Mercedes-Benz S-Class, following a complete makeover in 2021, continued to impress with its sleek design and luxurious features. The S-Class, rooted in a long history dating back to the 1954 “Ponton” models, represented the pinnacle of Mercedes-Benz’s sedan lineup. The seventh-generation S-Class, code-named “W223,” maintained its flagship status with a sleek exterior and a long distance between the front axle and dashboard, enhancing its elegance. The interior featured high-quality materials, a 12.8-inch touchscreen, and a 12.3-inch digital instrument panel, providing a visually stunning and technologically advanced cabin.

Picture of 2022 Lexus IS
Picture of 2022 Lexus IS
Picture of 2022 Lexus IS
Picture of 2022 Lexus IS
Picture of 2022 Lexus IS
Picture of 2022 Lexus IS
Picture of 2022 Lexus IS
Picture of 2022 Lexus IS
Picture of 2022 Lexus IS
Performance

2022 Lexus IS

9/10

2022 Mercedes-Benz S-Class

8/10

The 2022 Lexus IS 500 F Sport Performance was powered by a 5.0-liter V8 engine, producing 472 horsepower at 7,100 rpm and 395 lb-ft of torque at 4,800 rpm. This engine, shared with the RC F and LC 500, was paired with an eight-speed Sport Direct Shift automatic transmission and a limited-slip differential. The IS 500 featured adaptive variable suspension and a Yamaha rear performance damper, ensuring a comfortable ride and stable handling. Lexus claimed a 0-60 mph time of 4.4 seconds. Despite its thrilling performance, the IS 500’s fuel efficiency was a drawback, averaging 17.7 mpg during evaluation, below the EPA rating of 20 mpg combined.

The 2022 Mercedes-Benz S500 featured a turbocharged 3.0-liter inline-six-cylinder mild-hybrid engine with EQ Boost, delivering 429 horsepower and 384 lb-ft of torque. The EQ Boost system added up to 21 horsepower and 184 lb-ft of torque during high-demand situations. The S500 used a nine-speed automatic transmission and standard 4Matic AWD, achieving a 0-60 mph time of 4.9 seconds. The S580, with a twin-turbocharged 4.0-liter V8 and the same EQ Boost system, reached 0-60 mph in 4.4 seconds. The S500 offered fuel economy of 21 mpg city/30 mpg highway/24 mpg combined, while the S580 was rated at 16 mpg city/25 mpg highway/19 mpg combined.

Form and function

2022 Lexus IS

7/10

2022 Mercedes-Benz S-Class

9/10

The 2022 Lexus IS 500 F Sport Performance provided a comfortable and well-equipped interior. The front seats were snug yet supportive, with effective bolstering and a driving position that enhanced control. Rear seats were adequate for average-height adults, though lacking in smartphone charging options. The climate control system excelled in maintaining a cool cabin, essential in hot climates. However, storage space was limited, with a small 10.8-cubic-foot trunk and a center console touchpad occupying valuable space. The control layout was user-friendly, with clear buttons and knobs complementing the touchscreen infotainment system.

The 2022 Mercedes-Benz S-Class excelled in providing a luxurious and spacious cabin. Second-row passengers enjoyed powered sun blinds, a Panorama Sunroof, and a 13.8-cubic-foot trunk for ample storage. The cabin featured six USB-C ports and a 115-volt power supply in the second row. Front seats offered heating, ventilation, massage functions, and memory settings, ensuring long-distance comfort. The Luxury Line added features like a heated steering wheel and rear-seat heating, while the Executive Line (exclusive to the S580) catered to chauffeured passengers with advanced rear-seat amenities. Soft-close doors added a touch of convenience, though their wide opening angle could be challenging for some occupants.

Technology

2022 Lexus IS

10/10

2022 Mercedes-Benz S-Class

9/10

The 2022 Lexus IS 500 F Sport Performance benefited from a touchscreen infotainment system introduced in 2021, addressing previous ergonomic issues. The system included an 8-inch touchscreen, Apple CarPlay, Android Auto, Amazon Alexa, and SiriusXM satellite radio. The IS 500 Premium added a 10.3-inch touchscreen, navigation, and a 17-speaker Mark Levinson audio system, delivering impressive sound quality. The dynamic voice command system was highly effective, accurately handling voice queries and commands.

The 2022 Mercedes-Benz S-Class featured a 12.8-inch OLED touchscreen as the centerpiece of its MBUX infotainment system. The OLED technology provided superior image quality and energy efficiency. The 12.3-inch LED virtual instrument panel offered customizable visual themes, with an optional 3D instrument cluster adding depth and visual interest. The augmented video for navigation and available augmented reality head-up display enhanced driving assistance. The standard Burmester 3D Surround sound system and optional Burmester 4D Surround system provided an exceptional audio experience. The EQ Boost system and available rear-axle steering further enhanced the S-Class’s performance and maneuverability.

Safety

2022 Lexus IS

8/10

2022 Mercedes-Benz S-Class

9/10

The 2022 Lexus IS came standard with Lexus Safety System+ 2.5, a comprehensive suite of safety features. This included lane-departure warning, adaptive cruise control with lane-centering assistance, and low-speed automatic braking. While effective in many situations, some features, like the Curve Speed Reduction function and low-speed automatic braking, could be overly aggressive. The IS earned the highest overall rating of “Top Safety Pick+” from the IIHS and a five-star overall rating from the NHTSA, though it received a four-star rating for frontal-impact collision for the driver and front passenger.

The 2022 Mercedes-Benz S-Class was equipped with an extensive array of safety and driver assistance features. Magic Vision Control optimized windshield spray, while active distance assist Distronic, active brake assist, and active lane-keeping assist provided comprehensive driving support. The Pre-Safe systems prepared the car for imminent collisions, and car-to-x communication shared road condition warnings. Executive-level safety features included rear-passenger airbags and rear-seat belt bags, enhancing protection for all occupants.

CarGurus highlights

Winning Vehicle Image

According to CarGurus experts, the overall rating for the 2022 Lexus IS is 8.2 out of 10, while the 2022 Mercedes-Benz S-Class scores 8.7 out of 10. Based on these ratings, the 2022 Mercedes-Benz S-Class is the recommended choice, offering superior luxury, advanced technology, and comprehensive safety features.

CarGurus highlights

Winning Vehicle Image

According to CarGurus experts, the overall rating for the 2022 Lexus IS is 8.2 out of 10, while the 2022 Mercedes-Benz S-Class scores 8.7 out of 10. Based on these ratings, the 2022 Mercedes-Benz S-Class is the recommended choice, offering superior luxury, advanced technology, and comprehensive safety features.

CarGurus logo

By: CarGurus + AI

At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.

Popular vehicle comparisons

2023 Subaru Impreza vs 2024 Lexus IS2023 BMW 5 Series vs 2024 Mercedes-Benz S-Class2023 Mercedes-Benz E-Class vs 2024 Mercedes-Benz S-Class2023 Mercedes-Benz S-Class vs 2024 Mercedes-Benz S-Class2023 Kia K5 vs 2023 Lexus IS2023 Lexus IS vs 2023 Honda Civic Hatchback2023 Volkswagen Golf GTI vs 2024 Mercedes-Benz S-Class2023 MINI Cooper vs 2024 Mercedes-Benz S-Class2023 Mercedes-Benz S-Class vs 2023 Hyundai Sonata2023 Honda Civic Hatchback vs 2024 Mercedes-Benz S-Class2023 Honda Civic vs 2023 Lexus IS2023 Subaru Impreza vs 2023 Lexus IS2023 Kia K5 vs 2024 Mercedes-Benz S-Class2023 Toyota Prius vs 2024 Mercedes-Benz S-Class2023 Mercedes-Benz S-Class vs 2023 Kia K52022 Honda Civic Hatchback vs 2023 Lexus IS2022 Mercedes-Benz E-Class vs 2023 Lexus IS2022 Volkswagen Jetta vs 2023 Mercedes-Benz S-Class2022 Chrysler 300 vs 2023 Lexus IS2022 MINI Cooper vs 2023 Lexus IS2022 Volkswagen Golf GTI vs 2023 Mercedes-Benz S-Class2022 Mercedes-Benz E-Class vs 2023 Mercedes-Benz S-Class2022 Subaru Impreza vs 2023 Mercedes-Benz S-Class2022 Honda Civic Hatchback vs 2023 Mercedes-Benz S-Class2022 MINI Cooper vs 2023 Mercedes-Benz S-Class2022 Mercedes-Benz S-Class vs 2023 Mercedes-Benz S-Class2022 Hyundai Elantra vs 2023 Mercedes-Benz S-Class2022 Honda Accord vs 2023 Mercedes-Benz S-Class2022 BMW 5 Series vs 2023 Mercedes-Benz S-Class2022 Kia K5 vs 2023 Mercedes-Benz S-Class2021 Lexus IS vs 2022 Volkswagen Golf GTI2021 Mercedes-Benz S-Class vs 2022 Hyundai Elantra2021 Lexus IS vs 2022 Mercedes-Benz S-Class2021 Mercedes-Benz S-Class vs 2022 Kia K52021 Lexus IS vs 2022 Honda Civic Hatchback2021 Mercedes-Benz S-Class vs 2022 Honda Civic2021 Lexus IS vs 2022 Volkswagen Jetta2021 Mercedes-Benz S-Class vs 2022 Volkswagen Passat2021 Lexus IS vs 2022 Hyundai Sonata2021 Lexus IS vs 2022 Mercedes-Benz E-Class2021 Lexus IS vs 2022 Volkswagen Passat2021 Mercedes-Benz S-Class vs 2022 Subaru Impreza2021 Lexus IS vs 2022 Honda Accord2021 Lexus IS vs 2022 Chevrolet Malibu2020 Audi A4 vs 2021 Mercedes-Benz S-Class2020 Mercedes-Benz S-Class vs 2020 Audi A42020 Hyundai Elantra vs 2020 Lexus IS2020 MINI Cooper vs 2020 Lexus IS2020 Honda Civic Hatchback vs 2020 Lexus IS2020 Subaru Impreza vs 2020 Lexus IS2020 Hyundai Sonata vs 2020 Mercedes-Benz S-Class2020 Volkswagen Golf GTI vs 2021 Mercedes-Benz S-Class2020 Honda Accord vs 2021 Mercedes-Benz S-Class2020 BMW 5 Series vs 2020 Lexus IS2020 Chevrolet Malibu vs 2021 Mercedes-Benz S-Class2020 Chrysler 300 vs 2020 Mercedes-Benz S-Class2020 Toyota Prius vs 2021 Lexus IS2020 Mercedes-Benz C-Class vs 2021 Mercedes-Benz S-Class2019 Honda Accord vs 2020 Lexus IS2019 Chrysler 300 vs 2020 Lexus IS2019 Mercedes-Benz C-Class vs 2020 Lexus IS2019 Mercedes-Benz E-Class vs 2020 Mercedes-Benz S-Class2019 MINI Cooper vs 2020 Mercedes-Benz S-Class2019 Volkswagen Jetta vs 2020 Lexus IS2019 Hyundai Sonata vs 2020 Mercedes-Benz S-Class2019 Toyota Prius vs 2020 Mercedes-Benz S-Class2019 Honda Civic Hatchback vs 2020 Lexus IS2019 BMW 5 Series vs 2020 Mercedes-Benz S-Class2019 Honda Accord vs 2020 Mercedes-Benz S-Class2019 Audi A4 vs 2020 Mercedes-Benz S-Class2019 Toyota Prius vs 2020 Lexus IS2019 MINI Cooper vs 2020 Lexus IS