2021 Lexus IS vs 2022 Mercedes-Benz S-Class

2021 Lexus IS
2021 Lexus IS
$39,050MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now
2021 Lexus IS
$39,050MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now
Overview

MSRP

$39,050

MSRP

$111,100

Average price

$35,817

Average price

$95,002

Listings

471

Listings

308
Ratings & Reviews
User Reviews
User Reviews

Expert reviews

7.3 out of 10

Expert reviews

8.7 out of 10
Pros
  • Stylish design
  • Multiple powertrain options
  • Great handling
Cons
  • Underwhelming base engine
  • Irritating transmission
  • Outdated technology
Pros
  • Stylish design
  • Great ride quality
  • Premium interior materials
Cons
  • Potentially polarizing design
  • No getting around the high price tag

2021 Lexus IS Reviews Summary

The Lexus IS enters its fourth generation of production, embodying lessons learned from the LC and RC. The 2021 IS targets enthusiast drivers and luxury buyers who might be thinking German first, and it seeks to recalibrate expectations of what a compact luxury sports sedan can be.

2022 Mercedes-Benz S-Class Reviews Summary

The 2022 Mercedes-Benz S-Class is a full-size four-door luxury sedan with a 48-volt mild hybrid gasoline-electric powertrain, including a turbocharged 3.0-liter inline six-cylinder gas engine (S500) or twin-turbo 4.0-liter V8 (S580), with EQ Boost, a nine-speed automatic transmission, and all-wheel drive (AWD). The S500 starts at $111,100; the S580 starts at $117,700. The EPA estimates the S500 can achieve fuel economy of up to 21 mpg city/30 mpg highway/24 mpg combined, while the S580 is rated at 16 mpg city/25 mpg highway/19 mpg combined.
No video found
Popular Features & Specs

Engine

2.0L 241 hp I4

Engine

3.0L 429 hp I6

Drive Train

RWD

Drive Train

AWD

Seating Capacity

5

Seating Capacity

5

Horsepower

241 hp @ 5800 rpm

Horsepower

429 hp @ 6100 rpm

MPG City

21

MPG City

21

MPG Highway

31

MPG Highway

30
2021 Lexus IS
2021 Lexus IS
$39,050MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now
2021 Lexus IS
$39,050MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now
Overview
MSRP
$39,050
$111,100
Average price
$35,817
$95,002
Listings
Ratings & Reviews
User reviews
4.5
4.8
Expert reviews

7.3 out of 10

Read full review

8.7 out of 10

Read full review
Pros & cons
Pros
  • Stylish design
  • Multiple powertrain options
  • Great handling
Cons
  • Underwhelming base engine
  • Irritating transmission
  • Outdated technology
Pros
  • Stylish design
  • Great ride quality
  • Premium interior materials
Cons
  • Potentially polarizing design
  • No getting around the high price tag
Summary
The Lexus IS enters its fourth generation of production, embodying lessons learned from the LC and RC. The 2021 IS targets enthusiast drivers and luxury buyers who might be thinking German first, and it seeks to recalibrate expectations of what a compact luxury sports sedan can be.
The 2022 Mercedes-Benz S-Class is a full-size four-door luxury sedan with a 48-volt mild hybrid gasoline-electric powertrain, including a turbocharged 3.0-liter inline six-cylinder gas engine (S500) or twin-turbo 4.0-liter V8 (S580), with EQ Boost, a nine-speed automatic transmission, and all-wheel drive (AWD). The S500 starts at $111,100; the S580 starts at $117,700. The EPA estimates the S500 can achieve fuel economy of up to 21 mpg city/30 mpg highway/24 mpg combined, while the S580 is rated at 16 mpg city/25 mpg highway/19 mpg combined.
Video
No video found
Popular Features & Specs
Engine
2.0L 241 hp I4
3.0L 429 hp I6
Drive Train
RWD
AWD
Seating Capacity
5
5
Horsepower
241 hp @ 5800 rpm
429 hp @ 6100 rpm
MPG City
21
21
MPG Highway
31
30
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By: CarGurus + AI

This car comparison has been created with using generative AI. It is based entirely on CarGurus expert review content, ratings and data, and leverages our extensive library of hands-on product tests to create thousands of unique comparisons to help shoppers choose the right car.