Used 2022 Mercedes-Benz S-Class for Sale nearTampa, FL

Compare 2022 Mercedes-Benz S-Class Trims in Tampa, FL

The S-Class offers a range of luxury trims, from the value-oriented S 500 to the high-performance Maybach models, all featuring AWD.

• Starting at $67,502
• Best MPG/MPGe: 21 city / 30 hwy
• Most Popular: S 580 4MATIC AWD

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

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Trim Deep Dives

S 500 4MATIC AWD — "Who It's For"

The S 500 is the pick for shoppers who want luxury features without the higher price of the Maybach models.

• Avg. market price: $81,401 (updated weekly)
• MPG/MPGe: 21 city / 30 hwy
• Inventory: 54 listings
• View S 500 4MATIC AWD listings

S 580 4MATIC AWD — "Who It's For"

The S 580 is the pick for shoppers who want a powerful V8 engine and a wealth of luxury features without going to the top tier.

• Avg. market price: $67,502 (updated weekly)
• MPG/MPGe: 16 city / 25 hwy
• Inventory: 103 listings — widest selection in the lineup
• View S 580 4MATIC AWD listings

Maybach S 580 4MATIC AWD — "Who It's For"

The Maybach S 580 is the pick for shoppers who want the ultimate in luxury and comfort, though availability is limited.

• Avg. market price: $136,995 (updated weekly)
• MPG/MPGe: 15 city / 24 hwy
• Inventory: 18 listings — lower availability; may limit negotiating room
• View Maybach S 580 4MATIC AWD listings

Maybach S 680 4MATIC AWD — "Who It's For"

The Maybach S 680 is the pick for shoppers who want the highest performance and luxury features, but it comes at a premium price.

• Avg. market price: $81,401 (updated weekly)
• MPG/MPGe: 12 city / 21 hwy
• Inventory: 18 listings — lower availability; may limit negotiating room
• View Maybach S 680 4MATIC AWD listings

Trim Recommendations

Most Popular — S 580 4MATIC AWD

With 103 active listings, the S 580 4MATIC AWD is the clear volume leader in the lineup.

Browse S 580 4MATIC AWD listings

Best Budget Option — S 580 4MATIC AWD

At $67,502 avg market price — below the lineup median of $81,401 — it's the most accessible entry point.

Browse S 580 4MATIC AWD listings

Best for Fuel Economy — S 500 4MATIC AWD

With an impressive MPG/MPGe of 21/30, the S 500 is the most fuel-efficient option in the lineup.

Browse S 500 4MATIC AWD listings

These recommendations are based on CarGurus' proprietary market data from September 12, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2022 Mercedes-Benz S-Class cost?

Prices have softened 10.58% compared to this time last year, making it a favorable time to shop this model year.

There are 1,129 listings available, which gives you a meaningful amount of inventory to compare.

Is the 2022 Mercedes-Benz S-Class a good car?

Yes — the 2022 Mercedes-Benz S-Class earns a 4.5/5 user rating and an 8.67/10 expert rating. The model scores 9/10 across Look and feel, Form and function, Technology, and Safety.

You’re looking at a full-size four-door luxury sedan that’s built to feel polished and substantial, with a stylish design, great ride quality, and premium interior materials. It also brings a 48-volt mild hybrid gasoline-electric setup, standard all-wheel drive, and a nine-speed automatic, so it has the hardware to match its flagship mission.

The main trade-offs are its potentially polarizing design and its high price tag. If you want executive-level comfort and a highly technical luxury sedan, this one fits that brief well.

32.3% of listings are priced as good or great deals, which suggests there are still some attractive opportunities if you shop carefully.

Is the 2022 Mercedes-Benz S-Class reliable?

Owners rate it 4.5/5, a strong signal of long-term satisfaction.

The S-Class is positioned as Mercedes-Benz’s flagship sedan, and the available information emphasizes advanced engineering, strong performance, and a highly refined cabin. Its mild-hybrid powertrains, standard all-wheel drive, and extensive driver-assistance tech point to a vehicle designed for confident daily use and long-distance comfort.

The performance setup also supports that impression: the S500 and S580 both use EQ Boost, a nine-speed automatic, and standard 4Matic AWD, while the chassis is described as smooth, responsive, and predictable. Mercedes also highlights the car’s executive-level safety systems and premium build quality, which are the kinds of traits you want in a long-term luxury sedan.

Mercedes notes that buyers who choose the sedan 4Matic should find little to complain about or regret, which is a reassuring sign for used-car shoppers. For you, the bigger ownership risk is less about the concept and more about making sure the specific car you buy has been well maintained and properly cared for.

What should I look for when buying a used 2022 Mercedes-Benz S-Class?

Accident-free inventory is solid at 86.3% — always verify the vehicle history report.

You should still check the history report carefully, because a clean listing percentage does not replace a proper records review. Prioritize a pre-purchase inspection that focuses on the condition of the electronics, suspension, and luxury features, since this is a highly equipped flagship sedan. You’ll also want to confirm that the car’s maintenance history matches its premium positioning.

Key things to evaluate:

• Trim level: The S500 4Matic Sedan starts in Luxury Line and AMG Line, while the S580 4Matic Sedan adds Executive Line at the top. The Luxury Line is the entry point, while the AMG Line and Executive Line add more equipment and a more upscale presentation.
• Powertrain: The S500 uses a turbocharged 3.0-liter inline-six-cylinder mild-hybrid setup, while the S580 uses a twin-turbo 4.0-liter V8. Both use EQ Boost, a nine-speed automatic transmission, and standard 4Matic AWD.
• Safety package: Standard and available driver-assistance features include active distance assist Distronic adaptive cruise control with route-based speed adaptation, active stop-and-go assist, active steering assist with active emergency stop assist and active lane-change assistant, active brake assist with cross-traffic function and turn-off function, active speed limit assist with traffic sign assist, active blind-spot assist with exit warning, active lane-keeping assist, active parking assist with Parktronic, Pre-Safe Plus with Pre-Safe Sound, and Pre-Safe Impulse Side. Available rear-passenger airbags and rear-seat belt bag are also offered.
• Infotainment: The cabin centers on a 12.8-inch OLED touchscreen with the MBUX infotainment system, paired with a 12.3-inch digital instrument panel. The setup also includes standard augmented video for navigation, and an available augmented reality head-up display.
• Fuel efficiency: The S500 is rated at up to 21 mpg city, 30 mpg highway, and 24 mpg combined, while the S580 is rated at 16 mpg city, 25 mpg highway, and 19 mpg combined.

Which 2022 Mercedes-Benz S-Class trim should I buy?

The 2022 Mercedes-Benz S-Class is offered in 5 trim levels: S500 4Matic Sedan Luxury Line, S500 4Matic Sedan AMG Line, S580 4Matic Sedan Luxury Line, S580 4Matic Sedan AMG Line, S580 4Matic Sedan Executive Line.

Here's the short version:

• S500 4Matic Sedan Luxury Line: This is the entry point, and it gives you the core S-Class experience with the six-cylinder mild-hybrid powertrain, standard AWD, and the flagship cabin tech. It’s the best-value starting point if you want the S-Class nameplate without stretching to the pricier V8 trims.
• S500 4Matic Sedan AMG Line: Choose this if you want the same S500 powertrain but a sportier appearance and a more expensive presentation. It makes sense if style matters to you, but it’s not the value pick.
• S580 4Matic Sedan Luxury Line: This is the step up if you want the V8 and stronger acceleration while staying in the more restrained Luxury Line trim. It suits you if performance matters more than keeping the purchase price down.
• S580 4Matic Sedan AMG Line: This combines the V8 with the AMG Line look, so you’re paying for both extra power and a more aggressive appearance. It’s for buyers who want the more dramatic version of the S-Class.
• S580 4Matic Sedan Executive Line: This is the top trim and the most upscale choice in the lineup. If you want the most lavish version of the 2022 S-Class, this is the one to target.

The safety content also notes executive-level upgrades for the second row, plus available rear-passenger airbags and a rear-seat belt bag.

Is now a good time to buy a used 2022 Mercedes-Benz S-Class?

This is a moderate market for selective buyers, so you can shop with some leverage if you’re patient.

• Deal availability: 32.3% of listings are priced as good or great deals.
• Inventory: There are 1,129 listings available.
• Price trend: Prices have softened 10.58% compared with last year.
• Clean inventory: 86.3% of listings are accident-free.

If you find a listing below $63,177, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz S-Class's resale value?

The current average of $63,618 sits slightly below last year's $71,148.

That decline suggests the market has already adjusted downward, which can help you as a buyer but may limit upside if you plan to resell soon. If you buy at the right price, you reduce the risk of taking a bigger depreciation hit later.

For a future seller, the key is to buy carefully and avoid overpaying relative to the current market. A well-kept example with desirable equipment should still attract attention, but the recent price softening means you should expect resale values to remain sensitive to condition and mileage.

Vehicles with strong owner satisfaction ratings, like this model year's 4.5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz S-Class safe?

The 2022 Mercedes-Benz S-Class gets loaded with standard and available safety and advanced driver assistance systems, with some executive-level upgrades for the second row.

It earns a 9/10 safety score from our experts.

Mercedes includes active distance assist Distronic adaptive cruise control with route-based speed adaptation, active stop-and-go assist, active steering assist with active emergency stop assist and active lane-change assistant, active brake assist with cross-traffic function and turn-off function, active speed limit assist with traffic sign assist, active blind-spot assist with exit warning, active lane-keeping assist, active parking assist with Parktronic, Pre-Safe Plus with Pre-Safe Sound, and Pre-Safe Impulse Side. The car also includes car-to-x communication and Magic Vision Control.

For rear-seat passengers, Mercedes offers available rear-passenger airbags and a rear-seat belt bag. That said, some of the more advanced protection features are available rather than standard, so you’ll want to confirm the exact equipment on the car you’re considering.

Should I buy a 2022 Mercedes-Benz S-Class or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 32.3% of listings are priced as good or great deals.
• Accident-free inventory is solid at 86.3% — always verify the vehicle history report.
• Price trend: Prices have softened 10.58% compared with last year.
• Owners rate it 4.5/5 — a strong satisfaction signal.
• The 2022 combines a polished redesign with strong ride quality, premium materials, and standard AWD.

Consider the 2021 if:

• At $59,063, the 2021 costs less than the current year's $63,618 average.
• Mercedes used the redesign to make the S-Class a technology showcase.

Consider the 2023 if:

• At $78,185, the 2023 costs more than the current year's $63,618 average.
• It adds a new plug-in hybrid powertrain for buyers wanting a more modern setup.

The bottom line: If you want the best balance of price, luxury, and modern tech, the 2022 is the smart default. If your priority is spending less, the 2021 is the better value play. If you want the newer powertrain and don’t mind paying more, the 2023 is the upgrade path.

These recommendations are based on CarGurus' proprietary market data from September 15, 2026, CarGurus experts' opinions, and generative AI.